SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 ILE H 140
LEU H 146
GLY J  62
VAL H 113
ALA H 112
 None
 1.12A 1axwA-5lc5H:
undetectable		 1axwA-5lc5H:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 5 GLU M 433
ALA M 435
SER M 438
HIS M 440
 None
 1.08A 1errA-5lc5M:
undetectable
1errB-5lc5M:
undetectable		 1errA-5lc5M:
21.90
1errB-5lc5M:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 4 ILE N  13
LEU K  73
VAL J 167
ILE J 163
 None
 0.85A 1fm6D-5lc5N:
undetectable		 1fm6D-5lc5N:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 11 ALA K  68
GLU K  34
LEU A  63
ILE A  69
LEU J 161
 None
 1.24A 1g50A-5lc5K:
undetectable		 1g50A-5lc5K:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 TYR C 124
GLY D 254
LEU D 260
VAL D 245
 None
 1.07A 1gsfA-5lc5C:
undetectable		 1gsfA-5lc5C:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 TYR C 124
GLY D 254
LEU D 260
VAL D 245
 None
 1.08A 1gsfB-5lc5C:
undetectable		 1gsfB-5lc5C:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 TYR C 124
GLY D 254
LEU D 260
VAL D 245
 None
 1.07A 1gsfD-5lc5C:
undetectable		 1gsfD-5lc5C:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 10 LEU M  39
LEU M 446
LEU M 447
HIS M 440
LEU M 439
 None
 1.11A 1gwrA-5lc5M:
undetectable		 1gwrA-5lc5M:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 8 GLU M 335
ASN M 331
LEU M 436
ALA M 435
 None
 0.83A 1hwiB-5lc5M:
undetectable		 1hwiB-5lc5M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 8 GLU M 335
ASN M 331
LEU M 436
ALA M 435
 None
 0.81A 1hwiC-5lc5M:
undetectable		 1hwiC-5lc5M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 9 LEU K  78
ASP K  88
LEU K  26
THR N  57
ILE J 171
 None
 1.40A 1hzeA-5lc5K:
undetectable
1hzeB-5lc5K:
undetectable		 1hzeA-5lc5K:
20.00
1hzeB-5lc5K:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 9 ILE J 171
LEU K  78
ASP K  88
LEU K  26
THR N  57
 None
 1.41A 1hzeA-5lc5J:
undetectable
1hzeB-5lc5J:
undetectable		 1hzeA-5lc5J:
21.21
1hzeB-5lc5J:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 8 LEU N  61
SER K  24
ASP K  88
THR J  76
 None
 1.03A 1ig3A-5lc5N:
undetectable
1ig3B-5lc5N:
undetectable		 1ig3A-5lc5N:
20.77
1ig3B-5lc5N:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 VAL g  69
LEU M  33
LEU M  32
LEU M  77
 None
 0.84A 1j8uA-5lc5g:
undetectable		 1j8uA-5lc5g:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 6 TRP N  84
VAL N  74
ILE N  75
LEU J  52
 None
 1.05A 1j96A-5lc5N:
undetectable		 1j96A-5lc5N:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		3 / 3 ALA N  94
VAL N  74
TRP N  26
 None
 0.91A 1jnoA-5lc5N:
undetectable		 1jnoA-5lc5N:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		3 / 3 ALA N  94
VAL N  74
TRP N  26
 None
 0.90A 1jnoB-5lc5N:
undetectable		 1jnoB-5lc5N:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 LEU M 216
ILE M 270
THR M 272
TRP M 267
 None
 1.27A 1kglA-5lc5M:
undetectable		 1kglA-5lc5M:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		3 / 3 ALA N  94
VAL N  74
TRP N  26
 None
 0.93A 1nruA-5lc5N:
undetectable		 1nruA-5lc5N:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		3 / 3 ALA N  94
VAL N  74
TRP N  26
 None
 0.93A 1nruB-5lc5N:
undetectable		 1nruB-5lc5N:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 10 ALA K  68
GLU K  34
LEU A  63
ILE A  69
LEU J 161
 None
 1.20A 1pcgA-5lc5K:
undetectable		 1pcgA-5lc5K:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 11 SER M 339
LEU M 282
THR M 341
MET M 413
THR M 414
 None
 1.06A 1pkvA-5lc5M:
undetectable
1pkvB-5lc5M:
undetectable		 1pkvA-5lc5M:
12.05
1pkvB-5lc5M:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 11 SER M 339
LEU M 282
THR M 341
MET M 413
THR M 414
 None
 1.00A 1pkvA-5lc5M:
undetectable
1pkvB-5lc5M:
undetectable		 1pkvA-5lc5M:
12.05
1pkvB-5lc5M:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 10 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.01A 1pxxA-5lc5M:
undetectable		 1pxxA-5lc5M:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.00A 1pxxC-5lc5M:
undetectable		 1pxxC-5lc5M:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 10 ALA N  55
GLU N 117
LEU K  95
LEU K  93
HIS N  48
 None
 1.41A 1qkuA-5lc5N:
undetectable		 1qkuA-5lc5N:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 10 ALA N  55
GLU N 117
LEU K  95
LEU K  93
HIS N  48
 None
 1.40A 1qkuB-5lc5N:
undetectable		 1qkuB-5lc5N:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 10 ALA N  55
GLU N 117
LEU K  95
LEU K  93
HIS N  48
 None
 1.40A 1qkuC-5lc5N:
undetectable		 1qkuC-5lc5N:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus;
Bos
taurus) 		5 / 12 ILE H 140
LEU H 146
GLY J  62
VAL H 113
ALA H 112
 None
 1.05A 1tlsA-5lc5H:
undetectable		 1tlsA-5lc5H:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus;
Bos
taurus) 		5 / 12 ILE H 140
LEU H 146
GLY J  62
VAL H 113
ALA H 112
 None
 1.05A 1tlsB-5lc5H:
undetectable		 1tlsB-5lc5H:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 PHE g  62
LEU M  11
MET M  78
SER M  80
 None
 1.05A 1wrlE-5lc5g:
undetectable		 1wrlE-5lc5g:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 12 ALA d  47
ILE d  48
ILE N 239
VAL N 242
MET N 215
 None
 1.08A 1xozA-5lc5d:
undetectable		 1xozA-5lc5d:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		3 / 3 LEU K  20
LEU N  61
MET N 104
 None
 0.58A 1ya3B-5lc5K:
undetectable		 1ya3B-5lc5K:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 6 LEU M  68
GLY M 320
SER M 324
HIS M 440
 None
 0.96A 1yajF-5lc5M:
undetectable		 1yajF-5lc5M:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 THR N  12
PRO N  42
ILE N  19
SER J 160
ILE J 163
 None
 1.15A 1z9hD-5lc5N:
undetectable		 1z9hD-5lc5N:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 THR N  12
PRO N  42
ILE N  19
VAL J 156
ILE J 163
 None
 1.00A 1z9hD-5lc5N:
undetectable		 1z9hD-5lc5N:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M 126
LEU N 257
MET N 294
LEU N 245
THR M 153
 None
 1.39A 2aa5B-5lc5M:
undetectable		 2aa5B-5lc5M:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 ASP D 241
ASP D 295
ASN D 237
 None
 0.77A 2bm9D-5lc5D:
undetectable		 2bm9D-5lc5D:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 10 ALA M 202
GLN M 168
LEU M 174
SER M 157
LEU M 160
 None
 1.32A 2ceoB-5lc5M:
undetectable		 2ceoB-5lc5M:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 LYS M 237
SER M 289
VAL M 291
SER M 323
 None
 1.34A 2j9cA-5lc5M:
undetectable
2j9cB-5lc5M:
undetectable
2j9cC-5lc5M:
undetectable		 2j9cA-5lc5M:
13.04
2j9cB-5lc5M:
13.04
2j9cC-5lc5M:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		4 / 4 LEU N 296
LEU N 249
MET N 179
MET N 211
 None
 1.13A 2oaxB-5lc5N:
undetectable		 2oaxB-5lc5N:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 5 LEU N  27
LEU N  70
MET K  37
THR J 157
 None
 1.42A 2oaxD-5lc5N:
undetectable		 2oaxD-5lc5N:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		3 / 3 LEU N 153
MET N  96
MET N 139
 None
 0.76A 2vavF-5lc5N:
undetectable		 2vavF-5lc5N:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Bos
taurus) 		4 / 8 TYR d  73
LEU d  76
LEU d  31
HIS c  35
 None
 1.01A 2wekA-5lc5d:
undetectable		 2wekA-5lc5d:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 11 TYR N 293
LEU N 249
LEU N 257
LEU N 248
MET N 179
 None
 1.34A 2x7hA-5lc5N:
undetectable
2x7hB-5lc5N:
undetectable		 2x7hA-5lc5N:
22.68
2x7hB-5lc5N:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 4
(Bos
taurus;
Bos
taurus) 		3 / 3 VAL m  98
TRP m 100
TRP M 267
 None
 1.38A 2xdcC-5lc5m:
undetectable
2xdcD-5lc5m:
undetectable		 2xdcC-5lc5m:
10.77
2xdcD-5lc5m:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 ILE M 225
ALA M 124
LEU M 236
ILE M 132
MET M 229
 None
 1.32A 2xkwB-5lc5M:
undetectable		 2xkwB-5lc5M:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 SER D 119
ARG D 138
GLY D 142
ARG D 174
PHE D 178
 None
 1.28A 3a27A-5lc5D:
undetectable		 3a27A-5lc5D:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 VAL B 132
CYH B 136
LEU B  92
THR B  93
ASN B 121
 None
 1.07A 3a35A-5lc5B:
undetectable		 3a35A-5lc5B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 VAL B 132
CYH B 136
LEU B  92
THR B  93
ASN B 121
 None
 1.09A 3a3bA-5lc5B:
undetectable		 3a3bA-5lc5B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		5 / 12 MET H 233
PHE H 259
PHE H 237
ILE H 236
LEU H 100
 None
 1.31A 3aocC-5lc5H:
undetectable		 3aocC-5lc5H:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		5 / 12 SER H 157
MET H 233
PHE H 259
PHE H 237
LEU H 100
 None
 1.20A 3aocC-5lc5H:
undetectable		 3aocC-5lc5H:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
(Bos
taurus) 		4 / 6 ALA H  82
LEU H  83
ALA A  14
THR A  15
 None
 0.79A 3b6hA-5lc5H:
undetectable		 3b6hA-5lc5H:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
(Bos
taurus) 		4 / 6 ALA H  82
LEU H  83
ALA A  14
THR A  15
 None
 0.79A 3b6hB-5lc5H:
undetectable		 3b6hB-5lc5H:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 GLY J  42
CYH J  41
ILE J  34
LEU H 111
LEU K  38
 None
 1.11A 3cs8A-5lc5J:
undetectable		 3cs8A-5lc5J:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 GLY D 426
THR B  91
VAL D  61
LEU D 106
ASP D 429
 None
 1.27A 3d91B-5lc5D:
undetectable		 3d91B-5lc5D:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 6 VAL D 376
LEU C  96
ILE D  91
ILE D 391
 None
 0.96A 3gcsA-5lc5D:
undetectable		 3gcsA-5lc5D:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 MET D 111
CYH B  54
PRO B 150
 None
SF4  B 201 (-2.2A)
SF4  B 201 (-4.1A)
 1.34A 3h52C-5lc5D:
undetectable		 3h52C-5lc5D:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 MET B  86
CYH B 136
PRO B 141
 None
 1.25A 3h52C-5lc5B:
undetectable		 3h52C-5lc5B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 ASP D 422
CYH D 299
ASP D 295
TRP D 235
 None
 1.22A 3havA-5lc5D:
undetectable		 3havA-5lc5D:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 11 MET M 316
LEU M 238
LEU M 106
GLY M 242
LEU M 244
 None
 1.33A 3hm1B-5lc5M:
undetectable		 3hm1B-5lc5M:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 8 SER M 157
LEU M 154
TYR M 119
PHE N 260
 None
 0.95A 3i45A-5lc5M:
undetectable		 3i45A-5lc5M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		3 / 3 PRO M 224
PHE M 149
ALA M 233
 None
 0.67A 3itaD-5lc5M:
undetectable		 3itaD-5lc5M:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 12 ILE N 164
GLY N 165
GLY N 166
ILE N 162
PRO N 116
 None
 1.09A 3jayA-5lc5N:
undetectable		 3jayA-5lc5N:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		3 / 3 ASN D 149
ASP D 107
ARG C 104
 None
 0.86A 3k13A-5lc5D:
undetectable		 3k13A-5lc5D:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 ALA M 124
PHE N 260
LEU N 254
THR M 153
LEU M 150
 None
 1.16A 3k2hA-5lc5M:
undetectable		 3k2hA-5lc5M:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 7 GLY J  53
PHE K  12
GLY J  40
PHE J  13
 None
 0.87A 3ko0M-5lc5J:
undetectable
3ko0P-5lc5J:
undetectable		 3ko0M-5lc5J:
18.54
3ko0P-5lc5J:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		5 / 12 ALA K  68
ILE J  59
ASP A  66
LEU A  63
LEU K  33
 None
 1.32A 3lcvB-5lc5K:
undetectable		 3lcvB-5lc5K:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU K  75
LEU K  78
VAL K  79
SER K  82
VAL J  66
 None
 1.14A 3m7rA-5lc5K:
undetectable		 3m7rA-5lc5K:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		4 / 6 LEU D 159
PHE D 167
ALA B  63
THR B  49
 None
 1.12A 3mdrA-5lc5D:
undetectable		 3mdrA-5lc5D:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 MET D 164
PHE D 178
PHE D 168
ILE B  87
ALA B  89
 None
 1.19A 3nxuB-5lc5D:
undetectable		 3nxuB-5lc5D:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU K  73
ALA K  71
LEU A  63
LEU A  64
ILE J 171
 None
 1.00A 3olsB-5lc5K:
undetectable		 3olsB-5lc5K:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 12 LEU D 106
ALA B  53
GLY D 426
LEU D  83
ALA B  89
 None
SF4  B 201 (-3.3A)
None
None
None
 1.24A 3ou6C-5lc5D:
undetectable		 3ou6C-5lc5D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 12 LEU D 106
ALA B  53
GLY D 426
LEU D  83
ALA B  89
 None
SF4  B 201 (-3.3A)
None
None
None
 1.26A 3ou7C-5lc5D:
undetectable		 3ou7C-5lc5D:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 GLN D 266
PRO D 286
GLN D 306
GLU D 303
 None
 1.13A 3oyaA-5lc5D:
undetectable		 3oyaA-5lc5D:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		5 / 12 GLY J  62
VAL J  67
ALA K  71
LEU J  58
SER H 110
 None
 1.00A 3p2kD-5lc5J:
undetectable		 3p2kD-5lc5J:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
(Bos
taurus) 		5 / 12 VAL H 144
PRO A  74
ILE A  95
VAL H 305
CYH H 301
 None
 1.44A 3p6gA-5lc5H:
undetectable		 3p6gA-5lc5H:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		4 / 6 GLN N 134
ILE N  40
SER N  67
SER N  64
 None
 1.16A 3pmzD-5lc5N:
undetectable		 3pmzD-5lc5N:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 HIS D  59
ILE D 423
TRP C 129
ILE D  80
 None
 1.04A 3sfeB-5lc5D:
undetectable
3sfeC-5lc5D:
2.2		 3sfeB-5lc5D:
19.81
3sfeC-5lc5D:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		4 / 6 PHE H 186
PHE H 270
ASN H 235
ALA H 239
 None
 0.94A 3t3sB-5lc5H:
undetectable		 3t3sB-5lc5H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		4 / 8 PHE H 186
PHE H 270
ASN H 235
ALA H 239
 None
 0.97A 3t3sE-5lc5H:
undetectable		 3t3sE-5lc5H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU H 298
GLY J 158
LEU J 161
GLU A  68
SER A 101
 None
 1.25A 3tbgA-5lc5H:
undetectable		 3tbgA-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU H 241
LEU H 151
GLY H 101
LEU H 100
PHE J  51
 None
 1.03A 3tbgA-5lc5H:
undetectable		 3tbgA-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU H 298
GLY J 158
LEU J 161
GLU A  68
SER A 101
 None
 1.26A 3tbgC-5lc5H:
undetectable		 3tbgC-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 5 ARG M 245
TYR M 241
PHE M 118
LEU M 115
 None
 1.34A 3tgvC-5lc5M:
undetectable		 3tgvC-5lc5M:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		3 / 3 LEU M 436
HIS M 440
MET M 437
 None
 0.89A 3thrD-5lc5M:
undetectable		 3thrD-5lc5M:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 ILE C 117
PHE C 142
GLU C  91
VAL C  57
VAL C 107
 None
 1.06A 3tmzA-5lc5C:
undetectable		 3tmzA-5lc5C:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 LEU M 351
LEU M 352
ASN M 333
ILE M 337
 None
 1.01A 3u5jA-5lc5M:
undetectable		 3u5jA-5lc5M:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.67A 3u5kA-5lc5D:
undetectable		 3u5kA-5lc5D:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.84A 3u5kB-5lc5D:
undetectable		 3u5kB-5lc5D:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.70A 3u5kC-5lc5D:
undetectable		 3u5kC-5lc5D:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.67A 3u5kD-5lc5D:
undetectable		 3u5kD-5lc5D:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 5 SER D 119
ILE D 128
GLY D 198
PRO D 130
 None
 1.05A 3uboB-5lc5D:
undetectable		 3uboB-5lc5D:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 11 MET M 316
LEU M 238
LEU M 106
GLY M 242
LEU M 244
 None
 1.28A 3uudA-5lc5M:
undetectable		 3uudA-5lc5M:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 4 LEU J  45
GLY J  42
MET A   4
PHE H 104
 None
 1.29A 3vaqB-5lc5J:
undetectable		 3vaqB-5lc5J:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
4,NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 4
(Bos
taurus;
Bos
taurus) 		3 / 3 VAL m  98
TRP m 100
TRP M 267
 None
 1.33A 3zq8A-5lc5m:
undetectable
3zq8B-5lc5m:
undetectable		 3zq8A-5lc5m:
10.77
3zq8B-5lc5m:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 ILE D 417
GLN D 421
GLY D 401
SER D 406
 None
 0.99A 4a3uB-5lc5D:
undetectable		 4a3uB-5lc5D:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 5 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.74A 4a9jA-5lc5D:
undetectable		 4a9jA-5lc5D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 5 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.77A 4a9jB-5lc5D:
undetectable		 4a9jB-5lc5D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 5 VAL D 184
LEU D 207
LEU D 203
ILE D 144
 None
 0.64A 4a9jC-5lc5D:
undetectable		 4a9jC-5lc5D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.06A 4coxA-5lc5M:
undetectable		 4coxA-5lc5M:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 8 PHE J  20
GLY J  32
LEU J  33
ILE J  34
 None
 0.71A 4em2A-5lc5J:
undetectable		 4em2A-5lc5J:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.76A 4eq4A-5lc5C:
undetectable		 4eq4A-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.75A 4eq4B-5lc5C:
undetectable		 4eq4B-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.74A 4eqlA-5lc5C:
undetectable		 4eqlA-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.75A 4eqlB-5lc5C:
undetectable		 4eqlB-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 10 ALA N  39
LEU N  38
GLY J 164
ALA N 101
MET N  98
 None
 1.49A 4fe1A-5lc5N:
undetectable
4fe1J-5lc5N:
undetectable		 4fe1A-5lc5N:
20.51
4fe1J-5lc5N:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 TYR D 294
LEU D 298
VAL D 301
GLU D 302
 None
 0.40A 4fgzB-5lc5D:
undetectable		 4fgzB-5lc5D:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		4 / 6 ARG B  66
GLU D 182
ARG D 183
ASP D 210
 None
 1.13A 4kcnA-5lc5B:
undetectable		 4kcnA-5lc5B:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		4 / 6 ARG B  66
GLU D 182
ARG D 183
ASP D 210
 None
 1.13A 4kcnB-5lc5B:
undetectable		 4kcnB-5lc5B:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		4 / 7 TYR H 127
VAL D 415
LEU D  47
LEU D  68
 None
 0.94A 4l1wA-5lc5H:
undetectable		 4l1wA-5lc5H:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		4 / 8 TYR H 127
VAL D 415
LEU D  47
LEU D  68
 None
 0.96A 4l1xA-5lc5H:
undetectable		 4l1xA-5lc5H:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 6 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.71A 4l39A-5lc5C:
undetectable		 4l39A-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
(Bos
taurus) 		4 / 7 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.71A 4l39B-5lc5C:
undetectable		 4l39B-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 9 THR M 134
LEU M 130
LEU N 248
TYR N 291
LEU M 147
 None
 1.33A 4ltwA-5lc5M:
undetectable		 4ltwA-5lc5M:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		4 / 5 TYR A 104
THR N  57
LEU K  77
THR A  61
 None
 1.43A 4mbsB-5lc5A:
undetectable		 4mbsB-5lc5A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		4 / 7 HIS H 247
ILE H 166
TYR H 255
ASN H  97
 None
 1.44A 4o7gA-5lc5H:
undetectable
4o7gB-5lc5H:
undetectable		 4o7gA-5lc5H:
22.57
4o7gB-5lc5H:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.08A 4otyA-5lc5M:
undetectable		 4otyA-5lc5M:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 MET D 152
MET D 112
TYR D 108
 None
 1.39A 4p6xI-5lc5D:
undetectable		 4p6xI-5lc5D:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 11 ALA K  68
GLU K  34
LEU A  63
ILE A  69
LEU J 161
 None
 1.22A 4pxmB-5lc5K:
undetectable		 4pxmB-5lc5K:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		5 / 12 LEU D 229
VAL D 154
PRO D 166
THR D 165
GLY H  29
 None
 1.35A 4q15A-5lc5D:
undetectable		 4q15A-5lc5D:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 HIS D  84
SER B 131
THR D  87
ARG B 134
GLY B 123
 None
 1.22A 4qwuV-5lc5D:
undetectable
4qwub-5lc5D:
undetectable		 4qwuV-5lc5D:
18.18
4qwub-5lc5D:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 HIS D  84
SER B 131
THR D  87
ARG B 134
GLY B 123
 None
 1.23A 4qwuH-5lc5D:
undetectable
4qwuN-5lc5D:
undetectable		 4qwuH-5lc5D:
18.18
4qwuN-5lc5D:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.06A 4rrxA-5lc5M:
undetectable		 4rrxA-5lc5M:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.06A 4rrxB-5lc5M:
undetectable		 4rrxB-5lc5M:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 8 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.05A 4tzcB-5lc5M:
undetectable
4tzcD-5lc5M:
undetectable		 4tzcB-5lc5M:
12.27
4tzcD-5lc5M:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU J  45
ASN J  46
GLY J  48
MET H  98
ILE J   5
 None
 1.40A 4udcA-5lc5J:
undetectable		 4udcA-5lc5J:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		5 / 9 LEU H 298
LEU J 161
GLU A  68
SER A 101
VAL H 144
 None
 1.14A 4wnvB-5lc5H:
undetectable		 4wnvB-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		5 / 7 LEU H 298
GLU A  68
SER A 101
THR A  61
VAL H 144
 None
 1.24A 4wnvD-5lc5H:
undetectable		 4wnvD-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 12 THR N  99
LEU N 155
MET N 187
LEU N 142
PRO N 195
 None
 1.19A 4xi3A-5lc5N:
undetectable		 4xi3A-5lc5N:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 10 THR M 129
LEU M 130
THR M 153
LEU M 154
LEU M 150
 None
 1.03A 4z91A-5lc5M:
undetectable
4z91B-5lc5M:
undetectable
4z91C-5lc5M:
undetectable
4z91D-5lc5M:
undetectable
4z91E-5lc5M:
undetectable		 4z91A-5lc5M:
21.55
4z91B-5lc5M:
21.55
4z91C-5lc5M:
21.55
4z91D-5lc5M:
21.55
4z91E-5lc5M:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 LEU M 147
THR M 134
THR N 301
THR N 297
 None
 0.89A 4z91F-5lc5M:
undetectable
4z91G-5lc5M:
undetectable
4z91H-5lc5M:
undetectable
4z91I-5lc5M:
undetectable
4z91J-5lc5M:
undetectable		 4z91F-5lc5M:
21.55
4z91G-5lc5M:
21.55
4z91H-5lc5M:
21.55
4z91I-5lc5M:
21.55
4z91J-5lc5M:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR N 301
THR N 297
LEU M 147
THR M 134
 None
 0.96A 4z91F-5lc5N:
undetectable
4z91G-5lc5N:
undetectable
4z91H-5lc5N:
undetectable
4z91I-5lc5N:
undetectable
4z91J-5lc5N:
undetectable		 4z91F-5lc5N:
21.14
4z91G-5lc5N:
21.14
4z91H-5lc5N:
21.14
4z91I-5lc5N:
21.14
4z91J-5lc5N:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR M 129
LEU M 130
THR M 153
LEU M 154
 None
 0.74A 4z91F-5lc5M:
undetectable
4z91G-5lc5M:
undetectable
4z91H-5lc5M:
undetectable
4z91I-5lc5M:
undetectable
4z91J-5lc5M:
undetectable		 4z91F-5lc5M:
21.55
4z91G-5lc5M:
21.55
4z91H-5lc5M:
21.55
4z91I-5lc5M:
21.55
4z91J-5lc5M:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 12 ALA K  44
LEU N  27
LEU K  63
LEU K  64
LEU N  78
 None
 1.21A 4zn7A-5lc5K:
undetectable		 4zn7A-5lc5K:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 12 LEU K  73
ALA K  71
LEU A  63
LEU A  64
LEU K  30
 None
 0.98A 4zn7A-5lc5K:
undetectable		 4zn7A-5lc5K:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 HIS D  84
SER B 131
THR D  87
ARG B 134
GLY B 123
 None
 1.20A 5bxnV-5lc5D:
undetectable
5bxnb-5lc5D:
undetectable		 5bxnV-5lc5D:
18.18
5bxnb-5lc5D:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 HIS D  84
SER B 131
THR D  87
ARG B 134
GLY B 123
 None
 1.22A 5bxnH-5lc5D:
undetectable
5bxnN-5lc5D:
undetectable		 5bxnH-5lc5D:
18.18
5bxnN-5lc5D:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus;
Bos
taurus) 		5 / 11 PHE J  68
LEU H 146
LEU J  61
GLY J  62
ALA H 107
 None
 1.35A 5fctA-5lc5J:
undetectable		 5fctA-5lc5J:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		5 / 11 PHE A  56
LEU N  38
LEU K  75
GLY K  74
ALA K  68
 None
 1.36A 5fctA-5lc5A:
undetectable		 5fctA-5lc5A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		4 / 6 ILE N 209
TYR N 208
PHE N 216
THR N 119
 None
 0.89A 5g08A-5lc5N:
undetectable		 5g08A-5lc5N:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 12 PRO N 116
ALA N 180
LEU N 296
SER N 229
LEU K  95
 None
 1.10A 5hv1A-5lc5N:
undetectable		 5hv1A-5lc5N:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 12 LEU K  40
MET K  43
ILE N  76
ALA N 101
LEU N  97
 None
 1.36A 5ienA-5lc5K:
undetectable		 5ienA-5lc5K:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 12 LEU H 100
PHE H 160
LEU H 103
ILE J  59
LEU K  64
 None
 1.13A 5ienB-5lc5H:
undetectable		 5ienB-5lc5H:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 9 ILE N 122
PRO N 123
VAL J 167
ILE J 171
LEU N 131
 None
 1.38A 5iepA-5lc5N:
undetectable		 5iepA-5lc5N:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Bos
taurus) 		4 / 5 PRO d  52
HIS c   9
LEU c  21
TYR d  64
 None
 1.28A 5igjA-5lc5d:
undetectable		 5igjA-5lc5d:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.04A 5ikqA-5lc5M:
undetectable		 5ikqA-5lc5M:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.07A 5ikqB-5lc5M:
undetectable		 5ikqB-5lc5M:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 5 SER M 308
VAL M 381
GLY M 311
ALA M 312
 None
 1.07A 5k50A-5lc5M:
undetectable		 5k50A-5lc5M:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		3 / 3 LYS N  58
GLN K  91
ASN K  92
 None
 0.97A 5l2tA-5lc5N:
undetectable		 5l2tA-5lc5N:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		5 / 11 ALA H 221
GLU H  59
ALA H  18
THR H  21
LEU B  45
 None
 1.13A 5lf7H-5lc5H:
undetectable
5lf7I-5lc5H:
undetectable		 5lf7H-5lc5H:
23.42
5lf7I-5lc5H:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		5 / 11 ALA H 221
GLU H  59
ALA H  18
THR H  21
LEU B  45
 None
 1.08A 5lf7V-5lc5H:
undetectable
5lf7W-5lc5H:
undetectable		 5lf7V-5lc5H:
23.42
5lf7W-5lc5H:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 6 LEU M 216
ILE M 270
THR M 272
TRP M 267
 None
 1.41A 5ljeA-5lc5M:
undetectable		 5ljeA-5lc5M:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 10 GLU H 143
LEU J  54
ALA H 107
SER H 109
GLY J  63
 None
 1.11A 5m5cE-5lc5H:
undetectable		 5m5cE-5lc5H:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 8 SER J  50
ASN H  99
LEU H 100
SER H 163
 None
 0.93A 5m8rB-5lc5J:
undetectable		 5m8rB-5lc5J:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		4 / 8 SER J  50
ASN H  99
LEU H 100
SER H 163
 None
 0.94A 5m8rD-5lc5J:
undetectable		 5m8rD-5lc5J:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 10 ILE N 244
ILE d  44
ALA d  47
ILE d  48
ILE N 239
 None
 1.03A 5mvmD-5lc5N:
undetectable
5mvmE-5lc5N:
undetectable		 5mvmD-5lc5N:
11.71
5mvmE-5lc5N:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
(Bos
taurus) 		4 / 4 LEU H 294
MET H 184
ILE A  95
LEU H 300
 None
 1.39A 5nfpA-5lc5H:
undetectable		 5nfpA-5lc5H:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Bos
taurus) 		5 / 12 LEU K  95
VAL N 118
LEU K  93
MET N  45
LEU N  61
 None
 1.03A 5og9B-5lc5K:
undetectable		 5og9B-5lc5K:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 6 PRO N 255
LEU M 117
PHE M 118
LEU M 164
 None
 1.09A 5tl8A-5lc5N:
undetectable		 5tl8A-5lc5N:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		5 / 12 ALA M 300
GLY M 311
GLY M 377
ILE M 373
LEU M  68
 None
 1.16A 5ul4A-5lc5M:
undetectable		 5ul4A-5lc5M:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		5 / 12 LEU D 229
VAL D 154
PRO D 166
THR D 165
GLY H  29
 None
 1.27A 5xipA-5lc5D:
undetectable		 5xipA-5lc5D:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus;
Bos
taurus) 		3 / 3 ARG H  25
PHE H 224
ARG B  77
 None
 1.05A 5y9yA-5lc5H:
undetectable		 5y9yA-5lc5H:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.07A 5yizG-5lc5M:
undetectable
5yizY-5lc5M:
undetectable		 5yizG-5lc5M:
10.54
5yizY-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.08A 5yizk-5lc5M:
undetectable
5yizt-5lc5M:
undetectable		 5yizk-5lc5M:
10.54
5yizt-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.06A 5yizk-5lc5M:
undetectable
5yizt-5lc5M:
undetectable		 5yizk-5lc5M:
10.54
5yizt-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.07A 5yizG-5lc5M:
undetectable
5yizY-5lc5M:
undetectable		 5yizG-5lc5M:
10.54
5yizY-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.09A 5yj0G-5lc5M:
undetectable
5yj0Y-5lc5M:
undetectable		 5yj0G-5lc5M:
10.54
5yj0Y-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.08A 5yj0k-5lc5M:
undetectable
5yj0t-5lc5M:
undetectable		 5yj0k-5lc5M:
10.54
5yj0t-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.07A 5yj0k-5lc5M:
undetectable
5yj0t-5lc5M:
undetectable		 5yj0k-5lc5M:
10.54
5yj0t-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 7 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.07A 5yj0G-5lc5M:
undetectable
5yj0Y-5lc5M:
undetectable		 5yj0G-5lc5M:
10.54
5yj0Y-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		4 / 8 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.09A 5yj1G-5lc5M:
undetectable
5yj1Y-5lc5M:
undetectable		 5yj1G-5lc5M:
12.44
5yj1Y-5lc5M:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		4 / 7 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.11A 5yj1k-5lc5M:
undetectable
5yj1t-5lc5M:
undetectable		 5yj1k-5lc5M:
12.44
5yj1t-5lc5M:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		4 / 7 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.08A 5yj1G-5lc5M:
undetectable
5yj1Y-5lc5M:
undetectable		 5yj1G-5lc5M:
12.44
5yj1Y-5lc5M:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus;
Bos
taurus) 		5 / 12 LEU A  71
ILE A  69
ILE J  59
LEU A  98
LEU J 161
 None
 0.94A 6ajiA-5lc5A:
undetectable		 6ajiA-5lc5A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
(Bos
taurus) 		5 / 10 ALA K  68
GLU K  34
LEU A  63
ILE A  69
LEU J 161
 None
 1.22A 6cbzB-5lc5K:
undetectable		 6cbzB-5lc5K:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Bos
taurus) 		5 / 12 LEU H 285
ILE H 187
PHE H 270
THR H 238
THR H 145
 None
 1.23A 6djzB-5lc5H:
undetectable		 6djzB-5lc5H:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Bos
taurus) 		5 / 12 LEU N 248
ILE N 178
THR N 119
THR N 226
LEU N 230
 None
 1.34A 6djzB-5lc5N:
undetectable		 6djzB-5lc5N:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 10 LEU D 251
SER C  74
ASP C  77
ILE D 265
SER D 256
 None
 1.42A 6dlzB-5lc5D:
2.9
6dlzC-5lc5D:
2.2		 6dlzB-5lc5D:
9.95
6dlzC-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 11 ILE D 265
SER D 256
LEU D 251
SER C  74
ASP C  77
 None
 1.42A 6dlzA-5lc5D:
2.2
6dlzD-5lc5D:
2.9		 6dlzA-5lc5D:
9.95
6dlzD-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 10 LEU D 251
SER C  74
ASP C  77
ILE D 265
SER D 256
 None
 1.42A 6dm1B-5lc5D:
2.9
6dm1C-5lc5D:
2.2		 6dm1B-5lc5D:
9.95
6dm1C-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus;
Bos
taurus) 		5 / 11 ILE D 265
SER D 256
LEU D 251
SER C  74
ASP C  77
 None
 1.41A 6dm1A-5lc5D:
2.2
6dm1D-5lc5D:
2.9		 6dm1A-5lc5D:
9.95
6dm1D-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Bos
taurus) 		4 / 6 LEU M 326
ALA M 362
SER M 407
THR M 414
 None
 0.98A 6f88A-5lc5M:
undetectable		 6f88A-5lc5M:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 GLY D 291
GLY D 264
ASP D 241
ASP D 413
ILE D 417
 None
 1.03A 6mhtA-5lc5D:
undetectable		 6mhtA-5lc5D:
21.89