SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 PHE A 212
LEU A 600
ALA A 602
ALA A 569
THR A 362
None
1.01A 1cbrA-5lc8A:
undetectable
1cbrA-5lc8A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 PHE A 212
LEU A 600
ALA A 602
ALA A 569
THR A 362
None
1.01A 1cbrB-5lc8A:
undetectable
1cbrB-5lc8A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 7 GLN A 365
GLU A 368
MET A 565
ALA A 233
None
1.37A 1linA-5lc8A:
undetectable
1linA-5lc8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.71A 1rjoA-5lc8A:
undetectable
1rjoA-5lc8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.66A 1rkyA-5lc8A:
undetectable
1rkyA-5lc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.70A 1w2zB-5lc8A:
undetectable
1w2zB-5lc8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.72A 1w2zC-5lc8A:
undetectable
1w2zC-5lc8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.69A 1w2zD-5lc8A:
undetectable
1w2zD-5lc8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ASP A 251
LEU A 283
ALA A 277
PHE A 317
PHE A 264
None
1.19A 2ejtA-5lc8A:
undetectable
2ejtA-5lc8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.72A 2oqeA-5lc8A:
undetectable
2oqeA-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.72A 2oqeB-5lc8A:
undetectable
2oqeB-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.71A 2oqeC-5lc8A:
undetectable
2oqeC-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.71A 2oqeD-5lc8A:
undetectable
2oqeD-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.71A 2oqeF-5lc8A:
undetectable
2oqeF-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 416
ILE A 113
THR A 109
LEU A 611
VAL A 189
ZPE  A 703 (-4.8A)
ZPE  A 703 ( 4.6A)
ZPE  A 703 ( 4.4A)
ZPE  A 703 ( 4.9A)
None
1.20A 2qo5A-5lc8A:
undetectable
2qo5A-5lc8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.69A 2w0qA-5lc8A:
undetectable
2w0qA-5lc8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.69A 2w0qB-5lc8A:
undetectable
2w0qB-5lc8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ALA A 496
SER A 505
GLY A 536
THR A 535
THR A 510
None
1.18A 2zifA-5lc8A:
undetectable
2zifA-5lc8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.72A 3hiiA-5lc8A:
undetectable
3hiiA-5lc8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 HIS A 382
HIS A 377
HIS A 555
FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
0.71A 3hiiB-5lc8A:
undetectable
3hiiB-5lc8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 10 TYR A 623
ILE A 491
TRP A 494
ILE A 679
PHE A 649
None
1.47A 3uf8A-5lc8A:
undetectable
3uf8A-5lc8A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 5 ARG A 481
LEU A 464
PRO A 244
ASP A 482
None
1.04A 3ufnA-5lc8A:
undetectable
3ufnB-5lc8A:
undetectable
3ufnA-5lc8A:
9.83
3ufnB-5lc8A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 LYS A 465
GLU A 462
TRP A 488
None
1.02A 3v4tH-5lc8A:
undetectable
3v4tH-5lc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 685
VAL A  89
ILE A 608
LEU A 425
VAL A  86
None
None
ZPE  A 703 ( 4.9A)
None
None
0.99A 3w68C-5lc8A:
undetectable
3w68C-5lc8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 7 THR A 392
HIS A 400
LEU A 544
PHE A 410
None
1.39A 4awuA-5lc8A:
undetectable
4awuA-5lc8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 113
THR A 109
THR A 567
ILE A 608
GLU A 373
ZPE  A 703 ( 4.6A)
ZPE  A 703 ( 4.4A)
None
ZPE  A 703 ( 4.9A)
ZPE  A 703 (-4.1A)
1.16A 4i41A-5lc8A:
undetectable
4i41A-5lc8A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 10 TYR A 623
ILE A 491
TRP A 494
ILE A 679
PHE A 649
None
1.43A 4laxA-5lc8A:
undetectable
4laxA-5lc8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 4 ILE A 608
ASN A 607
ILE A 192
VAL A 189
ZPE  A 703 ( 4.9A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.7A)
None
1.18A 4uy87-5lc8A:
undetectable
4uy87-5lc8A:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 5 SER A 195
GLN A 131
LEU A 124
PHE A 132
None
1.25A 5evyX-5lc8A:
undetectable
5evyX-5lc8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 11 PHE A 634
ILE A 548
TRP A 494
ILE A 679
PHE A 649
None
1.12A 5hw8D-5lc8A:
undetectable
5hw8D-5lc8A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 PHE A 455
LEU A 544
PHE A 531
ALA A 391
LEU A 396
None
1.11A 5iepA-5lc8A:
undetectable
5iepA-5lc8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 7 GLY A 429
ARG A 422
ASP A 432
ASN A  85
None
None
GOL  A 702 (-2.9A)
None
1.10A 5n5dB-5lc8A:
undetectable
5n5dB-5lc8A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A 107
LEU A 181
ILE A 117
LEU A 139
LEU A 611
None
None
None
None
ZPE  A 703 ( 4.9A)
1.17A 5toaB-5lc8A:
2.8
5toaB-5lc8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
3 / 3 SER A 552
HIS A 409
TYR A 623
None
0.84A 5y2tA-5lc8A:
undetectable
5y2tA-5lc8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A 147
HIS A 150
GLU A 144
GLU A 115
None
1.06A 6mn4B-5lc8A:
undetectable
6mn4B-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A 147
HIS A 150
GLU A 144
GLU A 115
None
1.15A 6mn4C-5lc8A:
undetectable
6mn4C-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A 147
HIS A 150
GLU A 144
GLU A 115
None
0.96A 6mn4D-5lc8A:
undetectable
6mn4D-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 192
ASN A 607
LEU A 116
LEU A 124
PHE A 132
ZPE  A 703 ( 4.7A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.3A)
None
None
1.31A 6r2eA-5lc8A:
undetectable
6r2eA-5lc8A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa)
5 / 11 ILE A 192
ASN A 607
LEU A 116
LEU A 124
PHE A 132
ZPE  A 703 ( 4.7A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.3A)
None
None
1.32A 6r2eG-5lc8A:
undetectable
6r2eG-5lc8A:
18.20