SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 0.97A 1hxbB-5lcnA:
undetectable		 1hxbB-5lcnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 VAL A  25
LEU A 205
SER A 207
ALA A 182
 None
 0.86A 1j8uA-5lcnA:
undetectable		 1j8uA-5lcnA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.02A 1ohrB-5lcnA:
undetectable		 1ohrB-5lcnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 PHE A 148
GLY A 151
GLU A 121
ALA A 170
VAL A 169
 None
 1.15A 2drdA-5lcnA:
undetectable		 2drdA-5lcnA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.05A 3ekqB-5lcnA:
undetectable		 3ekqB-5lcnA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ALA A 155
 None
 1.00A 3el0B-5lcnA:
undetectable		 3el0B-5lcnA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.04A 3k4vC-5lcnA:
undetectable		 3k4vC-5lcnA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LYS A 186
ALA A 182
GLY A 181
THR A 180
ASP A 233
 None
 1.29A 3mg0H-5lcnA:
undetectable
3mg0I-5lcnA:
undetectable		 3mg0H-5lcnA:
20.73
3mg0I-5lcnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.02A 3mwsB-5lcnA:
undetectable		 3mwsB-5lcnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 177
TYR A  84
GLY A 147
ALA A 152
 None
 1.32A 3pghA-5lcnA:
undetectable		 3pghA-5lcnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 TYR A  84
GLN A 269
ILE A 268
SER A  77
 None
 1.28A 3pmzD-5lcnA:
undetectable		 3pmzD-5lcnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 0.97A 3tkgD-5lcnA:
undetectable		 3tkgD-5lcnA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE A 244
LEU A 257
ILE A 229
ALA A 152
MET A 150
 None
 1.32A 4a83A-5lcnA:
undetectable		 4a83A-5lcnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.04A 4jecB-5lcnA:
undetectable		 4jecB-5lcnA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 TRP A 275
GLY A 168
MET A 287
ILE A 165
 None
 0.82A 4qogA-5lcnA:
3.4
4qogB-5lcnA:
3.4		 4qogA-5lcnA:
21.60
4qogB-5lcnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LYS A 186
ALA A 182
GLY A 181
THR A 180
ASP A 233
 None
 1.29A 5bxnV-5lcnA:
undetectable
5bxnW-5lcnA:
undetectable		 5bxnV-5lcnA:
20.35
5bxnW-5lcnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 4 VAL A 154
GLU A 121
GLY A 151
LEU A  72
 None
 1.22A 5g5gC-5lcnA:
0.4		 5g5gC-5lcnA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.10A 5kqxB-5lcnA:
undetectable		 5kqxB-5lcnA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 1.03A 5kqyA-5lcnA:
undetectable		 5kqyA-5lcnA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
VAL A 214
ILE A 175
ILE A 228
ILE A 156
 None
 0.98A 6dh3B-5lcnA:
undetectable		 6dh3B-5lcnA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 5lcn UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 4 MET A 150
GLY A  74
HIS A  73
GLY A 151
 None
 1.46A 6fgdA-5lcnA:
3.6		 6fgdA-5lcnA:
20.99