SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A1602
LEU A1210
LEU A1259
LEU A1307
 None
 1.19A 1a4lD-5lcwA:
undetectable		 1a4lD-5lcwA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 ASP A1625
ASP A1623
ARG A1702
TYR A1673
 None
 1.49A 1ceaA-5lcwA:
undetectable
1ceaB-5lcwA:
undetectable		 1ceaA-5lcwA:
4.50
1ceaB-5lcwA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.04A 1ddrA-5lcwA:
undetectable		 1ddrA-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.98A 1ddsA-5lcwA:
undetectable		 1ddsA-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		5 / 12 ALA S 171
ILE S 174
PHE S 175
PHE S 196
LEU S 136
 None
 1.19A 1dtlA-5lcwS:
undetectable		 1dtlA-5lcwS:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.91A 1dyiA-5lcwA:
undetectable		 1dyiA-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.97A 1dyiB-5lcwA:
undetectable		 1dyiB-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 ALA A1079
GLN A1075
TYR A1552
LEU A1105
 None
 1.15A 1e6wC-5lcwA:
undetectable		 1e6wC-5lcwA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 LEU A1307
LEU A1612
VAL A1255
GLY A1256
ALA A1301
 None
 1.14A 1e7aA-5lcwA:
2.7		 1e7aA-5lcwA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		6 / 12 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.48A 1eizA-5lcwA:
undetectable		 1eizA-5lcwA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		6 / 12 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.47A 1ej0A-5lcwA:
undetectable		 1ej0A-5lcwA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 THR A 433
VAL A 490
ILE A 587
VAL A 595
ILE A 609
 None
 1.27A 1gebA-5lcwA:
undetectable		 1gebA-5lcwA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 TYR A 642
THR A 487
LEU A 499
VAL A 509
ILE A 607
 None
 1.28A 1gebA-5lcwA:
undetectable		 1gebA-5lcwA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.16A 1hrkA-5lcwA:
undetectable		 1hrkA-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL Q 232
LEU Q 241
LEU Q 281
VAL Q 271
 None
 0.95A 1jgsA-5lcwQ:
undetectable		 1jgsA-5lcwQ:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL R 232
LEU R 241
LEU R 281
VAL R 271
 None
 0.95A 1jgsA-5lcwR:
undetectable		 1jgsA-5lcwR:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A1403
ASP A1361
GLU A1292
SER A1295
ALA A1370
 None
 1.42A 1m4dA-5lcwA:
undetectable		 1m4dA-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG S  36
ASP Q 184
ASN Q 188
 None
 0.76A 1nbhA-5lcwS:
undetectable		 1nbhA-5lcwS:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG S  36
ASP Q 184
ASN Q 188
 None
 0.73A 1nbhD-5lcwS:
undetectable		 1nbhD-5lcwS:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.84A 1ra8A-5lcwA:
undetectable		 1ra8A-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.80A 1rd7A-5lcwA:
undetectable		 1rd7A-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.87A 1rd7B-5lcwA:
undetectable		 1rd7B-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.98A 1rx7A-5lcwA:
undetectable		 1rx7A-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 PRO A 842
HIS A 767
LEU A 775
ILE A 844
 None
 1.20A 1sbrA-5lcwA:
undetectable
1sbrB-5lcwA:
undetectable		 1sbrA-5lcwA:
6.13
1sbrB-5lcwA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 6 ASN Q 329
ARG Q 445
ASN Q 183
GLN Q 401
 None
 1.44A 1t9uA-5lcwQ:
undetectable		 1t9uA-5lcwQ:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 6 ASN R 329
ARG R 445
ASN R 183
GLN R 401
 None
 1.44A 1t9uA-5lcwR:
undetectable		 1t9uA-5lcwR:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.96A 1tdrA-5lcwA:
undetectable		 1tdrA-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 GLU A 616
ALA A 613
LEU A 622
GLN A 619
GLU A 868
 None
 1.23A 1wrlC-5lcwA:
undetectable
1wrlD-5lcwA:
undetectable		 1wrlC-5lcwA:
3.45
1wrlD-5lcwA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS Q 301
HIS Q 267
VAL Q 312
LEU Q 305
THR Q 304
 None
 1.15A 1z9yA-5lcwQ:
undetectable		 1z9yA-5lcwQ:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS Q 301
HIS Q 267
VAL Q 312
LEU Q 305
THR Q 304
 None
 1.21A 1zgfA-5lcwQ:
undetectable		 1zgfA-5lcwQ:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS R 301
HIS R 267
VAL R 312
LEU R 305
THR R 304
 None
 1.22A 1zgfA-5lcwR:
undetectable		 1zgfA-5lcwR:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 SER A1349
GLU A1354
ASP A1361
 None
 0.91A 2avdB-5lcwA:
undetectable		 2avdB-5lcwA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 HIS A1461
ALA A1460
TYR A1463
LEU A1404
LEU A1512
 None
 1.30A 2azqA-5lcwA:
undetectable		 2azqA-5lcwA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		5 / 11 ASP R 330
GLY R 328
GLY R 284
ILE R 290
ALA S 297
 None
 0.99A 2b60B-5lcwR:
undetectable		 2b60B-5lcwR:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.90A 2d0kB-5lcwA:
undetectable		 2d0kB-5lcwA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 VAL A 123
VAL A 119
LEU A 154
ASP A 120
 None
 1.02A 2ddwA-5lcwA:
undetectable		 2ddwA-5lcwA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.18A 2hrcA-5lcwA:
undetectable		 2hrcA-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.20A 2po5A-5lcwA:
undetectable		 2po5A-5lcwA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A1657
PRO A1658
LEU A1663
ILE A1666
 None
 0.89A 2qd4A-5lcwA:
undetectable		 2qd4A-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 LEU A1181
SER A1579
VAL A1260
GLY A1258
MET A1304
 None
 1.42A 2qd4B-5lcwA:
undetectable		 2qd4B-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A 609
ALA A  13
LEU A  17
ILE A 607
ILE A 584
 None
 1.01A 2w9sA-5lcwA:
undetectable		 2w9sA-5lcwA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A 609
ALA A  13
LEU A  17
ILE A 607
ILE A 584
 None
 1.03A 2w9sB-5lcwA:
undetectable		 2w9sB-5lcwA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 ALA A1605
LEU A1612
LEU A1259
LEU A1210
LEU A1609
 None
 1.14A 2xn6A-5lcwA:
undetectable
2xn6B-5lcwA:
undetectable		 2xn6A-5lcwA:
11.49
2xn6B-5lcwA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU A1302
MET A1304
VAL A1254
ILE A1374
ALA A1370
 None
 1.06A 2yy8A-5lcwA:
undetectable
2yy8B-5lcwA:
undetectable		 2yy8A-5lcwA:
7.51
2yy8B-5lcwA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA A1298
ALA A1297
ALA A1301
GLN A1250
 None
 0.85A 3a2qA-5lcwA:
undetectable		 3a2qA-5lcwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU A1585
ALA A1410
ALA A1372
MET A1373
LEU A1307
 None
 1.09A 3bszE-5lcwA:
undetectable		 3bszE-5lcwA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A  12
ILE A 511
PRO A 512
LEU A 597
THR A 487
 None
 0.99A 3clbA-5lcwA:
undetectable		 3clbA-5lcwA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 9 ALA Q 398
ASP Q 397
GLY Q 376
ALA Q 372
ILE Q 382
 None
 1.09A 3ektB-5lcwQ:
undetectable		 3ektB-5lcwQ:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		3 / 3 TYR S 116
TYR S 141
GLY S 111
 None
 0.59A 3eteB-5lcwS:
undetectable
3eteD-5lcwS:
undetectable
3eteF-5lcwS:
undetectable		 3eteB-5lcwS:
20.16
3eteD-5lcwS:
20.16
3eteF-5lcwS:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER Q 266
HIS Q 293
GLY Q 288
VAL Q 312
GLY Q 284
 None
 0.91A 3f8wB-5lcwQ:
undetectable		 3f8wB-5lcwQ:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER R 266
HIS R 293
GLY R 288
VAL R 312
GLY R 284
 None
 0.91A 3f8wB-5lcwR:
undetectable		 3f8wB-5lcwR:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER Q 266
HIS Q 293
GLY Q 288
VAL Q 312
GLY Q 284
 None
 0.92A 3f8wC-5lcwQ:
undetectable		 3f8wC-5lcwQ:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER R 266
HIS R 293
GLY R 288
VAL R 312
GLY R 284
 None
 0.92A 3f8wC-5lcwR:
undetectable		 3f8wC-5lcwR:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ASN A1532
MET A1024
PHE A1566
 None
 0.65A 3g4lD-5lcwA:
undetectable		 3g4lD-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLY Q 376
GLY Q 375
GLN Q 401
VAL Q 402
ILE Q 382
 None
 1.28A 3h52B-5lcwQ:
undetectable		 3h52B-5lcwQ:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLY R 376
GLY R 375
GLN R 401
VAL R 402
ILE R 382
 None
 1.28A 3h52B-5lcwR:
undetectable		 3h52B-5lcwR:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 LEU A1325
PRO A1322
LEU A1371
ARG A1407
 None
 1.40A 3hcoA-5lcwA:
undetectable		 3hcoA-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 10 SER Q 285
LEU Q 189
ILE Q 229
SER Q 273
GLY Q 244
 None
 1.39A 3ijxB-5lcwQ:
undetectable
3ijxD-5lcwQ:
undetectable		 3ijxB-5lcwQ:
19.44
3ijxD-5lcwQ:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 10 SER R 285
LEU R 189
ILE R 229
SER R 273
GLY R 244
 None
 1.39A 3ijxB-5lcwR:
undetectable
3ijxD-5lcwR:
undetectable		 3ijxB-5lcwR:
18.65
3ijxD-5lcwR:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLU Q 249
GLY Q 244
ARG Q 270
VAL Q 232
ILE Q 229
 None
 1.20A 3jb2A-5lcwQ:
undetectable		 3jb2A-5lcwQ:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLU R 249
GLY R 244
ARG R 270
VAL R 232
ILE R 229
 None
 1.21A 3jb2A-5lcwR:
undetectable		 3jb2A-5lcwR:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.26A 3kw2A-5lcwA:
undetectable		 3kw2A-5lcwA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ASP A1385
ARG A1381
ALA A1384
 None
 0.79A 3mbgC-5lcwA:
undetectable		 3mbgC-5lcwA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.85A 3p50A-5lcwA:
5.1		 3p50A-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.85A 3p50B-5lcwA:
5.2		 3p50B-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.84A 3p50C-5lcwA:
5.2		 3p50C-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.85A 3p50D-5lcwA:
5.2		 3p50D-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.85A 3p50E-5lcwA:
5.2		 3p50E-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 LEU A1618
LEU A1656
LEU A1634
LEU A1651
 None
 0.81A 3q1eA-5lcwA:
3.8
3q1eC-5lcwA:
undetectable		 3q1eA-5lcwA:
5.43
3q1eC-5lcwA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 LEU A1634
LEU A1651
LEU A1618
LEU A1656
 None
 0.87A 3q1eA-5lcwA:
3.8
3q1eC-5lcwA:
undetectable		 3q1eA-5lcwA:
5.43
3q1eC-5lcwA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		3 / 3 GLU S 166
PHE S 168
GLN S 203
 None
 0.95A 3r55A-5lcwS:
undetectable		 3r55A-5lcwS:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 457
VAL A 455
PHE A 468
PHE A 248
ILE A 432
 None
 1.36A 3t3rD-5lcwA:
undetectable		 3t3rD-5lcwA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 TRP Q 407
PHE Q 473
PRO Q 365
TRP Q 366
 None
 1.20A 3v35A-5lcwQ:
undetectable		 3v35A-5lcwQ:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 TRP R 407
PHE R 473
PRO R 365
TRP R 366
 None
 1.20A 3v35A-5lcwR:
undetectable		 3v35A-5lcwR:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.30A 3w1wB-5lcwA:
undetectable		 3w1wB-5lcwA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		4 / 6 GLN S  91
ARG S  36
GLU S 161
LEU S  32
 None
 1.37A 4ax8A-5lcwS:
undetectable		 4ax8A-5lcwS:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1488
GLY A1531
ALA A1528
VAL A1535
GLY A1563
 None
 0.89A 4dc3A-5lcwA:
undetectable		 4dc3A-5lcwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.00A 4dfrA-5lcwA:
undetectable		 4dfrA-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA A1389
ALA A1468
GLY A1467
ILE A1465
 None
 0.60A 4eatA-5lcwA:
undetectable		 4eatA-5lcwA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.91A 4ej1A-5lcwA:
undetectable		 4ej1A-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.06A 4ej1B-5lcwA:
undetectable		 4ej1B-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 TYR A1172
TYR A1196
LEU A1176
ASN A1192
 None
 1.34A 4f8yC-5lcwA:
undetectable
4f8yD-5lcwA:
undetectable		 4f8yC-5lcwA:
7.33
4f8yD-5lcwA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.93A 4fhbA-5lcwA:
undetectable		 4fhbA-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 THR Q 457
ALA Q 459
SER Q 448
THR Q 450
 None
 0.66A 4ik7B-5lcwQ:
undetectable		 4ik7B-5lcwQ:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 THR R 457
ALA R 459
SER R 448
THR R 450
 None
 0.66A 4ik7B-5lcwR:
undetectable		 4ik7B-5lcwR:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 CYH A1586
GLN A1262
MET A1373
GLY A1308
LEU A1307
 None
 1.29A 4j7xB-5lcwA:
undetectable		 4j7xB-5lcwA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 GLY A1083
ALA A1142
LEU A1145
ILE A1193
LEU A1227
 None
 1.07A 4kt0A-5lcwA:
undetectable
4kt0J-5lcwA:
undetectable		 4kt0A-5lcwA:
17.21
4kt0J-5lcwA:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.90A 4p3rA-5lcwA:
undetectable		 4p3rA-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.88A 4pssA-5lcwA:
undetectable		 4pssA-5lcwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.85A 4qleA-5lcwA:
undetectable		 4qleA-5lcwA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.94A 4qlgB-5lcwA:
undetectable		 4qlgB-5lcwA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 ASP A1290
SER A1293
ARG A1600
ARG A1291
 None
 1.02A 4uhxA-5lcwA:
undetectable		 4uhxA-5lcwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN Q 329
SER Q 378
ALA Q 357
VAL Q 358
 None
 0.78A 4x1kC-5lcwQ:
undetectable		 4x1kC-5lcwQ:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN R 329
SER R 378
ALA R 357
VAL R 358
 None
 0.79A 4x1kC-5lcwR:
undetectable		 4x1kC-5lcwR:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.86A 4x5fA-5lcwA:
undetectable		 4x5fA-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.87A 4x5fB-5lcwA:
undetectable		 4x5fB-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.84A 4x5gA-5lcwA:
undetectable		 4x5gA-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.88A 4x5gB-5lcwA:
undetectable		 4x5gB-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.90A 4x5hA-5lcwA:
undetectable		 4x5hA-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.98A 5e8qB-5lcwA:
undetectable		 5e8qB-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.97A 5eajB-5lcwA:
undetectable		 5eajB-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.32A 5eb5A-5lcwA:
undetectable		 5eb5A-5lcwA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.28A 5eb5B-5lcwA:
undetectable		 5eb5B-5lcwA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.80A 5f1aA-5lcwA:
undetectable		 5f1aA-5lcwA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.80A 5f1aB-5lcwA:
undetectable		 5f1aB-5lcwA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.37A 5fj3A-5lcwA:
undetectable
5fj3B-5lcwA:
2.7		 5fj3A-5lcwA:
12.69
5fj3B-5lcwA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 CYH A1887
LEU A1800
LEU A1811
ALA A1796
 None
 1.07A 5hpuA-5lcwA:
undetectable
5hpuB-5lcwA:
undetectable		 5hpuA-5lcwA:
1.63
5hpuB-5lcwA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 ARG A1279
ALA A1297
VAL A1251
GLU A1276
ILE A1206
 None
 1.39A 5i3cA-5lcwA:
undetectable		 5i3cA-5lcwA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.00A 5ienB-5lcwA:
undetectable		 5ienB-5lcwA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens;
Homo
sapiens) 		4 / 4 TYR R 228
ARG R 286
PRO S 135
GLU S 161
 None
 1.47A 5im2A-5lcwR:
0.0		 5im2A-5lcwR:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mejA-5lcwA:
undetectable		 5mejA-5lcwA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mewA-5lcwA:
undetectable		 5mewA-5lcwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mhuA-5lcwA:
undetectable		 5mhuA-5lcwA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mhvA-5lcwA:
undetectable		 5mhvA-5lcwA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mhwA-5lcwA:
undetectable		 5mhwA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mhxA-5lcwA:
undetectable		 5mhxA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mhyA-5lcwA:
undetectable		 5mhyA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mhzA-5lcwA:
undetectable		 5mhzA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mi1A-5lcwA:
undetectable		 5mi1A-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mi2A-5lcwA:
undetectable		 5mi2A-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5miaA-5lcwA:
undetectable		 5miaA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5mibA-5lcwA:
undetectable		 5mibA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5micA-5lcwA:
undetectable		 5micA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.41A 5midA-5lcwA:
undetectable		 5midA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mieA-5lcwA:
undetectable		 5mieA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5migA-5lcwA:
undetectable		 5migA-5lcwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN Q 329
SER Q 378
ALA Q 357
VAL Q 358
 None
 0.68A 5nm5A-5lcwQ:
undetectable		 5nm5A-5lcwQ:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN R 329
SER R 378
ALA R 357
VAL R 358
 None
 0.69A 5nm5A-5lcwR:
undetectable		 5nm5A-5lcwR:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		3 / 3 HIS Q 300
HIS Q 301
HIS Q 291
 None
 0.81A 5oexA-5lcwQ:
8.9		 5oexA-5lcwQ:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		3 / 3 HIS R 300
HIS R 301
HIS R 291
 None
 0.82A 5oexA-5lcwR:
4.1		 5oexA-5lcwR:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.08A 5tl8A-5lcwA:
0.2		 5tl8A-5lcwA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A1609
LEU A1612
MET A1373
TYR A1589
 None
 1.18A 5uc3A-5lcwA:
undetectable		 5uc3A-5lcwA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.98A 5ujxB-5lcwA:
undetectable		 5ujxB-5lcwA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG A 588
ASP A 589
LEU A  76
SER A 103
 None
 1.09A 5uxcA-5lcwA:
1.8		 5uxcA-5lcwA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.36A 5vvnA-5lcwA:
undetectable
5vvnB-5lcwA:
undetectable		 5vvnA-5lcwA:
12.69
5vvnB-5lcwA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens) 		4 / 5 PRO S  74
GLY S  71
THR S  70
ASN S  72
 None
 1.13A 5x23A-5lcwS:
undetectable		 5x23A-5lcwS:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 HIS A  31
VAL A 119
LEU A  35
GLN A 155
 None
 1.31A 5xdhA-5lcwA:
undetectable
5xdhC-5lcwA:
undetectable		 5xdhA-5lcwA:
3.44
5xdhC-5lcwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLY Q 327
GLY Q 328
ASN Q 334
THR Q 373
TYR Q 185
 None
 1.46A 5yf0A-5lcwQ:
undetectable		 5yf0A-5lcwQ:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLY R 327
GLY R 328
ASN R 334
THR R 373
TYR R 185
 None
 1.45A 5yf0A-5lcwR:
undetectable		 5yf0A-5lcwR:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.85A 5z6jA-5lcwA:
undetectable		 5z6jA-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.85A 5z6kA-5lcwA:
undetectable		 5z6kA-5lcwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 ILE A1464
THR A1507
VAL A1506
GLU A1455
 None
 0.95A 6fbvC-5lcwA:
undetectable		 6fbvC-5lcwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A1303
LEU A1376
GLY A1308
LEU A1307
 None
 0.83A 6mdqA-5lcwA:
undetectable		 6mdqA-5lcwA:
3.28