SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 10 ALA A 164
LEU A 168
ILE A  33
HIS A  63
LEU A  65
 None
 1.45A 1a52A-5lcxA:
undetectable		 1a52A-5lcxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 10 ALA A 164
LEU A 168
ILE A  33
HIS A  63
LEU A  65
 None
 1.46A 1a52B-5lcxA:
undetectable		 1a52B-5lcxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 10 GLY A  18
ASN A  14
LEU A  25
VAL A  32
ALA A  94
 None
NAP  A 400 (-2.8A)
None
None
NAP  A 400 (-3.4A)
 1.18A 1fpqA-5lcxA:
6.2		 1fpqA-5lcxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 6 SER A 241
VAL A 151
GLY A  98
GLY A 146
 None
 0.78A 1tnlA-5lcxA:
undetectable		 1tnlA-5lcxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		3 / 3 ASP A 115
TYR A 111
GLU A 142
 None
 0.84A 1vm1A-5lcxA:
undetectable		 1vm1A-5lcxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  21
ASN A  14
LEU A  25
ALA A  26
VAL A 180
 None
NAP  A 400 (-2.8A)
None
None
NAP  A 400 (-4.0A)
 0.93A 1xdkA-5lcxA:
undetectable		 1xdkA-5lcxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 0.94A 1xlsA-5lcxA:
undetectable		 1xlsA-5lcxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 0.95A 1xlsB-5lcxA:
undetectable		 1xlsB-5lcxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 0.95A 1xlsC-5lcxA:
undetectable		 1xlsC-5lcxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 0.94A 1xlsD-5lcxA:
undetectable		 1xlsD-5lcxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 8 LEU A 119
GLU A 129
HIS A 234
ALA A 118
 None
 1.00A 2bnnA-5lcxA:
undetectable
2bnnB-5lcxA:
undetectable		 2bnnA-5lcxA:
22.90
2bnnB-5lcxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 6 SER A 241
VAL A 151
GLY A  98
GLY A 146
 None
 0.73A 2otvA-5lcxA:
undetectable		 2otvA-5lcxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 11 GLY A  16
LEU A 280
SER A 281
VAL A 282
ALA A 285
 NAP  A 400 (-3.5A)
None
None
None
None
 0.68A 3dcmX-5lcxA:
3.8		 3dcmX-5lcxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 6 ILE A  30
VAL A  32
LEU A  60
LEU A  53
 None
 0.86A 3kp6A-5lcxA:
undetectable
3kp6B-5lcxA:
undetectable		 3kp6A-5lcxA:
23.21
3kp6B-5lcxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 7 LEU A   9
LEU A  65
ASN A  92
THR A  68
 None
None
None
NAP  A 400 (-2.9A)
 0.90A 3lm8A-5lcxA:
2.6
3lm8C-5lcxA:
2.6		 3lm8A-5lcxA:
20.55
3lm8C-5lcxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		6 / 11 ARG A 307
ASN A  92
VAL A 178
GLY A  18
VAL A 288
ILE A 264
 None
 1.46A 3lzvB-5lcxA:
undetectable		 3lzvB-5lcxA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 9 GLU A  20
GLY A  18
VAL A  10
GLU A  44
GLY A  42
 None
 1.20A 4fimA-5lcxA:
undetectable		 4fimA-5lcxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 12 ILE A  30
ALA A 293
THR A  11
LEU A 165
LEU A  87
 None
 1.10A 4qzuC-5lcxA:
undetectable		 4qzuC-5lcxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		5 / 11 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 1.02A 5ji0A-5lcxA:
undetectable		 5ji0A-5lcxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5lcx (-)-ISOPIPERITENONE
REDUCTASE
(Mentha
x
piperita) 		4 / 5 SER A 106
VAL A 107
GLY A 138
ALA A 136
 None
 0.81A 5k50A-5lcxA:
16.2		 5k50A-5lcxA:
23.42