SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ld5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		4 / 7 ASN A 336
TYR A 340
ASN A 171
TYR A 334
 NAD  A 401 (-4.1A)
NAD  A 401 (-3.8A)
None
None
 1.03A 1dssG-5ld5A:
45.7		 1dssG-5ld5A:
46.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		7 / 7 SER A 167
THR A 169
ASN A 171
CYH A 172
TYR A 334
ASN A 336
TYR A 340
 GOL  A 404 (-3.0A)
GOL  A 404 ( 4.8A)
None
None
None
NAD  A 401 (-4.1A)
NAD  A 401 (-3.8A)
 0.23A 1dssG-5ld5A:
45.7		 1dssG-5ld5A:
46.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		4 / 8 ASN A 336
TYR A 340
ASN A 171
TYR A 334
 NAD  A 401 (-4.1A)
NAD  A 401 (-3.8A)
None
None
 1.03A 1dssR-5ld5A:
45.4		 1dssR-5ld5A:
46.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		8 / 8 SER A 167
THR A 169
ASN A 171
CYH A 172
HIS A 195
TYR A 334
ASN A 336
TYR A 340
 GOL  A 404 (-3.0A)
GOL  A 404 ( 4.8A)
None
None
None
None
NAD  A 401 (-4.1A)
NAD  A 401 (-3.8A)
 0.37A 1dssR-5ld5A:
45.4		 1dssR-5ld5A:
46.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		4 / 7 SER A 248
ILE A 234
THR A 260
THR A 193
 None
 0.83A 1sbrB-5ld5A:
undetectable		 1sbrB-5ld5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 12 TYR A 340
ALA A 138
ILE A 136
ALA A  32
ILE A  22
 NAD  A 401 (-3.8A)
NAD  A 401 (-3.4A)
None
None
None
 1.00A 2h42B-5ld5A:
undetectable		 2h42B-5ld5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 9 THR A 228
GLY A 247
LEU A 245
ALA A 230
THR A 170
 GOL  A 404 (-4.1A)
None
None
GOL  A 404 (-3.3A)
None
 1.11A 2npnA-5ld5A:
undetectable		 2npnA-5ld5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		4 / 8 ALA A 129
HIS A  98
GLY A 130
ILE A 127
 None
 0.92A 2zm9A-5ld5A:
undetectable		 2zm9A-5ld5A:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		8 / 8 SER A 167
THR A 169
ASN A 171
CYH A 172
HIS A 195
TYR A 334
ASN A 336
TYR A 340
 GOL  A 404 (-3.0A)
GOL  A 404 ( 4.8A)
None
None
None
None
NAD  A 401 (-4.1A)
NAD  A 401 (-3.8A)
 0.35A 3dmtC-5ld5A:
44.4		 3dmtC-5ld5A:
41.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 12 TYR A 334
ASN A 242
GLY A 229
ALA A 230
GLY A 235
 None
None
GOL  A 404 (-2.8A)
GOL  A 404 (-3.3A)
None
 0.92A 3hs6B-5ld5A:
undetectable		 3hs6B-5ld5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 10 ILE A  47
ALA A  21
MET A  36
SER A 137
ILE A  28
 None
None
None
NAD  A 401 (-3.0A)
NAD  A 401 (-4.4A)
 1.39A 3qg2A-5ld5A:
undetectable		 3qg2A-5ld5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 12 TYR A 334
ASN A 242
GLY A 229
ALA A 230
GLY A 235
 None
None
GOL  A 404 (-2.8A)
GOL  A 404 (-3.3A)
None
 0.91A 4e1gA-5ld5A:
undetectable		 4e1gA-5ld5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		3 / 3 THR A 170
ALA A 166
ASN A 171
 None
 0.57A 5ersA-5ld5A:
2.4		 5ersA-5ld5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		5 / 12 VAL A 328
PRO A 185
ALA A 184
SER A 332
ILE A 234
 None
 1.24A 5hv1A-5ld5A:
undetectable		 5hv1A-5ld5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Atopobium
vaginae) 		4 / 5 GLY A 257
ARG A 251
ASP A 335
GLN A  35
 None
 1.36A 5ubbA-5ld5A:
4.0		 5ubbA-5ld5A:
18.80