SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5lda JAMM1
(Pyrococcus
furiosus) 		5 / 9 GLU A  63
LEU A  56
GLU A  61
HIS A  88
GLY A  37
 None
None
None
ZN  A 201 (-3.4A)
None
 1.39A 1mjlA-5ldaA:
undetectable
1mjlB-5ldaA:
undetectable		 1mjlA-5ldaA:
22.22
1mjlB-5ldaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5lda JAMM1
SAMP2
(Pyrococcus
furiosus) 		3 / 3 TRP A 108
VAL B  65
PRO B  64
 None
 0.76A 1rg1A-5ldaA:
undetectable		 1rg1A-5ldaA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5lda JAMM1
SAMP2
(Pyrococcus
furiosus) 		3 / 3 TRP A 108
VAL B  65
PRO B  64
 None
 0.77A 1rh0A-5ldaA:
undetectable		 1rh0A-5ldaA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5lda JAMM1
(Pyrococcus
furiosus) 		4 / 8 HIS A  88
ASP A 101
SER A  98
HIS A  90
 ZN  A 201 (-3.4A)
ZN  A 201 (-2.2A)
ZN  A 201 ( 3.9A)
ZN  A 201 (-3.1A)
 1.12A 2xadC-5ldaA:
undetectable		 2xadC-5ldaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5lda JAMM1
SAMP2
(Pyrococcus
furiosus) 		4 / 4 VAL A  83
VAL A 110
ASN B  12
ILE B   9
 None
None
None
GOL  B 601 (-3.9A)
 1.10A 4cutA-5ldaA:
undetectable		 4cutA-5ldaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5lda JAMM1
SAMP2
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 6 CYH A  36
GLY B  69
GLY B  68
ASP A 101
 None
ZN  A 201 (-3.9A)
None
ZN  A 201 (-2.2A)
 1.05A 5a06D-5ldaA:
undetectable		 5a06D-5ldaA:
15.54