SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ldf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		4 / 6 PHE A 282
ILE A 356
GLY A 300
GLY A 299
 None
 0.74A 2qx6A-5ldfA:
undetectable
2qx6B-5ldfA:
undetectable		 2qx6A-5ldfA:
17.45
2qx6B-5ldfA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		4 / 8 MET A  65
ASP A  50
SER A  52
TYR A 100
 None
 1.37A 2v0gA-5ldfA:
undetectable		 2v0gA-5ldfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 PHE A 126
ALA A 275
ALA A 121
THR A 118
LEU A 379
 None
 1.11A 2x2nD-5ldfA:
undetectable		 2x2nD-5ldfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 GLU A 327
GLU A 131
ASN A 264
 None
 0.80A 3lp9B-5ldfA:
undetectable
3lp9D-5ldfA:
undetectable		 3lp9B-5ldfA:
20.54
3lp9D-5ldfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 GLU A 327
GLU A 212
ASN A 264
 None
 0.77A 3lp9B-5ldfA:
undetectable
3lp9D-5ldfA:
undetectable		 3lp9B-5ldfA:
20.54
3lp9D-5ldfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 9 ILE A 439
ILE A 443
ALA A 417
LEU A 421
ALA A 438
 None
 1.09A 3ozvB-5ldfA:
undetectable		 3ozvB-5ldfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 10 THR A 315
PRO A 363
ASN A 317
GLY A 265
ALA A 364
 None
 1.02A 3pp7B-5ldfA:
undetectable		 3pp7B-5ldfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 PHE A 282
SER A 291
GLN A 293
 None
 0.82A 3smtA-5ldfA:
undetectable		 3smtA-5ldfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		6 / 12 ASP A 424
ILE A 343
GLY A 378
ALA A 377
ALA A 305
SER A 342
 None
 1.27A 3sudB-5ldfA:
undetectable		 3sudB-5ldfA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 VAL A 124
ILE A 120
ILE A 386
MET A 376
LEU A 375
 None
 1.32A 4a84A-5ldfA:
undetectable		 4a84A-5ldfA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		4 / 5 HIS A 211
GLY A 178
TYR A 179
GLU A 220
 None
 1.49A 4ae1B-5ldfA:
undetectable		 4ae1B-5ldfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 HIS A 269
GLU A 212
ASN A 264
 None
 1.03A 4bupB-5ldfA:
0.3		 4bupB-5ldfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 LEU A 311
ALA A 111
ASP A 380
MET A 376
GLY A 378
 None
 1.46A 4j7xA-5ldfA:
undetectable		 4j7xA-5ldfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		4 / 6 GLU A 357
ARG A 355
GLU A 129
ARG A 339
 None
 1.45A 4kr3A-5ldfA:
undetectable		 4kr3A-5ldfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 11 GLY A  56
GLY A  55
ALA A 444
LEU A 445
GLU A 448
 None
 1.07A 4l8fB-5ldfA:
undetectable		 4l8fB-5ldfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 11 GLY A  56
GLY A  55
ALA A 444
LEU A 445
GLU A 448
 None
 1.06A 4l8fD-5ldfA:
undetectable		 4l8fD-5ldfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		4 / 7 ASP A 136
PHE A 135
GLY A 217
GLY A 156
 None
 0.94A 5n9xA-5ldfA:
undetectable		 5n9xA-5ldfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 LEU A 322
GLY A 265
GLU A 131
GLY A 267
ARG A 359
 None
 1.21A 5o4yD-5ldfA:
undetectable
5o4yE-5ldfA:
undetectable		 5o4yD-5ldfA:
2.47
5o4yE-5ldfA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 PHE A 126
ALA A 275
ALA A 121
THR A 118
LEU A 379
 None
 1.13A 5tl8A-5ldfA:
undetectable		 5tl8A-5ldfA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 HIS A 269
GLU A 212
ASN A 264
 None
 0.97A 5wbvA-5ldfA:
undetectable		 5wbvA-5ldfA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 HIS A 269
GLU A 212
ASN A 264
 None
 0.98A 5wbvB-5ldfA:
undetectable		 5wbvB-5ldfA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 PHE A 126
ALA A 275
ALA A 121
THR A 118
LEU A 379
 None
 1.16A 6aybA-5ldfA:
undetectable		 6aybA-5ldfA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		5 / 12 PHE A 126
ALA A 275
ALA A 121
THR A 118
LEU A 379
 None
 1.09A 6aycA-5ldfA:
undetectable		 6aycA-5ldfA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5ldf GLUTAMINE SYNTHETASE
(Salmonella
enterica) 		3 / 3 THR A  22
GLU A 449
ASN A 366
 None
 0.83A 6nj9K-5ldfA:
undetectable		 6nj9K-5ldfA:
21.96