SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ldw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		4 / 6 LYS B  27
GLU B  27
ALA B  31
LEU B  33
 None
 1.24A 1etb2-5ldwB:
undetectable		 1etb2-5ldwB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL
(Bos
taurus) 		5 / 11 ILE I 165
ILE I 131
GLU I 133
GLU I 164
ASN I 136
 None
SF4  I 202 (-4.8A)
None
None
None
 1.22A 2aqjA-5ldwI:
undetectable		 2aqjA-5ldwI:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 MET B  86
CYH B 136
PRO B 141
 None
 1.31A 3h52C-5ldwB:
undetectable		 3h52C-5ldwB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL
(Bos
taurus) 		4 / 4 LEU I  34
GLY I  33
GLY I  35
THR I  37
 None
 0.85A 3si7A-5ldwI:
undetectable		 3si7A-5ldwI:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 LEU I 155
LEU I  82
ILE I 131
ILE I 111
ALA I  91
 None
SF4  I 202 ( 4.2A)
SF4  I 202 (-4.8A)
None
SF4  I 201 ( 4.5A)
 1.08A 4ltwA-5ldwI:
undetectable		 4ltwA-5ldwI:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 PHE B  76
PHE B  72
GLY B 159
LEU B 161
ASP B  68
 None
 1.22A 4wnwA-5ldwB:
undetectable		 4wnwA-5ldwB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 VAL B 114
SER I 140
MET I 113
 None
 0.90A 5ikqA-5ldwB:
undetectable		 5ikqA-5ldwB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 TYR I 109
ASN I 156
LEU I  67
 None
 0.81A 6b58A-5ldwI:
undetectable		 6b58A-5ldwI:
14.26