SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5le4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.11A 3erdA-5le4A:
undetectable		 3erdA-5le4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 3hm1A-5le4A:
undetectable		 3hm1A-5le4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5le4 DD_D12_11_D12
(synthetic
construct) 		3 / 3 ARG A 236
THR A 247
THR A 206
 None
 0.80A 3k2hB-5le4A:
undetectable		 3k2hB-5le4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 12 VAL A  96
LEU A  84
LEU A 117
ILE A 128
ALA A 137
 None
 0.99A 4p65B-5le4A:
undetectable
4p65D-5le4A:
undetectable
4p65I-5le4A:
undetectable
4p65J-5le4A:
undetectable		 4p65B-5le4A:
10.50
4p65D-5le4A:
10.50
4p65I-5le4A:
6.03
4p65J-5le4A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 12 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-5le4A:
undetectable
4p65H-5le4A:
undetectable
4p65K-5le4A:
undetectable
4p65L-5le4A:
undetectable		 4p65F-5le4A:
10.50
4p65H-5le4A:
10.50
4p65K-5le4A:
6.03
4p65L-5le4A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 11 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.15A 4zn7B-5le4A:
undetectable		 4zn7B-5le4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5le4 DD_D12_11_D12
(synthetic
construct) 		5 / 12 ILE A  62
GLY A  58
THR A  90
LEU A  86
HIS A  85
 None
 1.41A 5v5zA-5le4A:
undetectable		 5v5zA-5le4A:
20.96