SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5le9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		3 / 3 ARG A 178
ARG A 212
ILE A 217
 None
 0.76A 1uobA-5le9A:
undetectable		 1uobA-5le9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 GLY A 180
GLY A 213
ARG A 184
HIS A 181
ILE A 189
 None
 1.08A 2b25B-5le9A:
undetectable		 2b25B-5le9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 VAL A 251
LEU A 239
LEU A 272
ILE A 283
ALA A 292
 None
 1.02A 4p65B-5le9A:
undetectable
4p65D-5le9A:
undetectable
4p65I-5le9A:
undetectable
4p65J-5le9A:
undetectable		 4p65B-5le9A:
7.72
4p65D-5le9A:
7.72
4p65I-5le9A:
6.17
4p65J-5le9A:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A 272
VAL A 251
LEU A 239
ILE A 283
ALA A 292
 None
 1.05A 4p65F-5le9A:
undetectable
4p65H-5le9A:
undetectable
4p65K-5le9A:
undetectable
4p65L-5le9A:
undetectable		 4p65F-5le9A:
7.72
4p65H-5le9A:
7.72
4p65K-5le9A:
6.17
4p65L-5le9A:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.23A 5nm5B-5le9A:
undetectable		 5nm5B-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.24A 5nm5B-5le9A:
undetectable		 5nm5B-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.28A 5xiwD-5le9A:
undetectable		 5xiwD-5le9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		5 / 12 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.30A 5xiwD-5le9A:
undetectable		 5xiwD-5le9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5le9 DD_OFF7_09_3G124
(synthetic
construct) 		4 / 8 HIS A  69
LEU A  14
GLY A  15
LEU A  18
 None
 0.74A 6mdqA-5le9A:
undetectable		 6mdqA-5le9A:
14.33