SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5leb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 ALA A 441
HIS A 422
GLU A 434
ALA A 425
LEU A 469
 None
 1.35A 1mjlA-5lebA:
undetectable
1mjlB-5lebA:
undetectable		 1mjlA-5lebA:
13.99
1mjlB-5lebA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 ALA A 441
HIS A 422
GLU A 434
LEU A 430
LEU A 469
 None
 1.19A 1mjlA-5lebA:
undetectable
1mjlB-5lebA:
undetectable		 1mjlA-5lebA:
13.99
1mjlB-5lebA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.06A 3erdA-5lebA:
undetectable		 3erdA-5lebA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.06A 3hm1A-5lebA:
undetectable		 3hm1A-5lebA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		4 / 7 VAL A 106
VAL A 139
ASN A 135
GLY A 136
 None
 1.03A 3kmoB-5lebA:
undetectable		 3kmoB-5lebA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		4 / 7 VAL A 225
VAL A 258
ASN A 254
GLY A 255
 None
 1.11A 3kmoB-5lebA:
undetectable		 3kmoB-5lebA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 ALA A  54
GLY A  58
TRP A  56
GLY A  61
LEU A  66
 None
 1.27A 3ou7A-5lebA:
undetectable		 3ou7A-5lebA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 ALA A 206
GLY A 210
TRP A 208
GLY A 213
LEU A 218
 None
 1.25A 3ou7A-5lebA:
undetectable		 3ou7A-5lebA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 ALA A  54
GLY A  58
TRP A  56
GLY A  61
LEU A  66
 None
 1.25A 3ou7D-5lebA:
undetectable		 3ou7D-5lebA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 ALA A 206
GLY A 210
TRP A 208
GLY A 213
LEU A 218
 None
 1.23A 3ou7D-5lebA:
undetectable		 3ou7D-5lebA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 PRO A 354
ALA A 326
ALA A 325
LEU A 317
LEU A 337
 None
 1.05A 3p2kA-5lebA:
undetectable		 3p2kA-5lebA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 1.02A 4p65B-5lebA:
undetectable
4p65D-5lebA:
undetectable
4p65I-5lebA:
undetectable
4p65J-5lebA:
undetectable		 4p65B-5lebA:
6.56
4p65D-5lebA:
6.56
4p65I-5lebA:
4.34
4p65J-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 VAL A  96
LEU A  84
LEU A 117
ILE A 128
ALA A 137
 None
 0.99A 4p65B-5lebA:
undetectable
4p65D-5lebA:
undetectable
4p65I-5lebA:
undetectable
4p65J-5lebA:
undetectable		 4p65B-5lebA:
6.56
4p65D-5lebA:
6.56
4p65I-5lebA:
4.34
4p65J-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 VAL A 248
LEU A 236
LEU A 269
ILE A 280
ALA A 289
 None
 0.98A 4p65B-5lebA:
undetectable
4p65D-5lebA:
undetectable
4p65I-5lebA:
undetectable
4p65J-5lebA:
undetectable		 4p65B-5lebA:
6.56
4p65D-5lebA:
6.56
4p65I-5lebA:
4.34
4p65J-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-5lebA:
undetectable
4p65H-5lebA:
undetectable
4p65K-5lebA:
undetectable
4p65L-5lebA:
undetectable		 4p65F-5lebA:
6.56
4p65H-5lebA:
6.56
4p65K-5lebA:
4.34
4p65L-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A 269
VAL A 248
LEU A 236
ILE A 280
ALA A 289
 None
 1.01A 4p65F-5lebA:
undetectable
4p65H-5lebA:
undetectable
4p65K-5lebA:
undetectable
4p65L-5lebA:
undetectable		 4p65F-5lebA:
6.56
4p65H-5lebA:
6.56
4p65K-5lebA:
4.34
4p65L-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 THR A 300
GLY A 265
THR A 266
ALA A 267
THR A 261
 None
 1.05A 4qvvH-5lebA:
undetectable		 4qvvH-5lebA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 THR A 300
GLY A 265
THR A 266
ALA A 267
THR A 261
 None
 1.05A 4qvvV-5lebA:
undetectable		 4qvvV-5lebA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 THR A 300
GLY A 265
THR A 266
ALA A 267
THR A 261
 None
 1.05A 4qvyH-5lebA:
undetectable		 4qvyH-5lebA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 4zn7B-5lebA:
undetectable		 4zn7B-5lebA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 11 THR A 300
GLY A 265
THR A 266
ALA A 267
THR A 261
 None
 1.06A 5d0xV-5lebA:
undetectable		 5d0xV-5lebA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A 236
ALA A 256
ASN A 287
ILE A 247
ALA A 239
 None
 1.28A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A 388
ALA A 408
ASN A 439
ILE A 399
ALA A 391
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5leb DDD_D12_06_D12_06_D1
2
(synthetic
construct) 		5 / 12 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.25A 5nm5B-5lebA:
undetectable		 5nm5B-5lebA:
21.14