SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 789
VAL A 794
TRP A 797
 None
 0.83A 1av2C-5lewA:
undetectable
1av2D-5lewA:
undetectable		 1av2C-5lewA:
1.83
1av2D-5lewA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 560
ALA A 448
GLY A 443
LEU A 583
PHE A 130
 None
 1.41A 1brpA-5lewA:
undetectable		 1brpA-5lewA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 422
ALA A 391
PRO A 414
ASN A 413
THR A 397
 None
 1.18A 1dhfA-5lewA:
undetectable		 1dhfA-5lewA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 164
THR A 224
HIS A  14
HIS A  16
GLU A  73
 None
None
ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1001 ( 2.2A)
 1.35A 1j36A-5lewA:
undetectable		 1j36A-5lewA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 THR A  17
HIS A  16
HIS A  14
GLU A  73
TYR A  75
 None
ZN  A1002 (-3.3A)
ZN  A1002 (-3.2A)
ZN  A1001 ( 2.2A)
SO4  A1004 (-4.9A)
 1.42A 1j36A-5lewA:
undetectable		 1j36A-5lewA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 164
THR A 224
HIS A  14
HIS A  16
GLU A  73
 None
None
ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1001 ( 2.2A)
 1.34A 1j36B-5lewA:
undetectable		 1j36B-5lewA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 THR A  17
HIS A  16
HIS A  14
GLU A  73
TYR A  75
 None
ZN  A1002 (-3.3A)
ZN  A1002 (-3.2A)
ZN  A1001 ( 2.2A)
SO4  A1004 (-4.9A)
 1.42A 1j36B-5lewA:
undetectable		 1j36B-5lewA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 423
GLY A 381
SER A 384
SER A 388
ASP A 421
 None
 1.45A 1m4iB-5lewA:
undetectable		 1m4iB-5lewA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  73
HIS A 107
HIS A  48
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.1A)
ZN  A1003 ( 3.3A)
 0.69A 1oe2A-5lewA:
undetectable		 1oe2A-5lewA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 367
ILE A 363
ALA A 438
ILE A 548
 None
 0.85A 1oniB-5lewA:
undetectable
1oniC-5lewA:
undetectable		 1oniB-5lewA:
9.07
1oniC-5lewA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.14A 1os2D-5lewA:
undetectable		 1os2D-5lewA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 193
VAL A 279
GLY A 281
ALA A 282
SER A 285
 None
 1.16A 1pxxB-5lewA:
undetectable		 1pxxB-5lewA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 193
VAL A 279
GLY A 281
ALA A 282
SER A 285
 None
 1.15A 1pxxD-5lewA:
undetectable		 1pxxD-5lewA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 193
LEU A 210
LEU A 176
ALA A 179
THR A 156
 None
 1.27A 1tz8A-5lewA:
undetectable
1tz8B-5lewA:
undetectable		 1tz8A-5lewA:
9.89
1tz8B-5lewA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.10A 1utzA-5lewA:
undetectable		 1utzA-5lewA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.10A 1utzB-5lewA:
undetectable		 1utzB-5lewA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 789
VAL A 794
TRP A 797
 None
 0.88A 1w5uC-5lewA:
undetectable
1w5uD-5lewA:
undetectable		 1w5uC-5lewA:
1.83
1w5uD-5lewA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 914
VAL A 843
LEU A 875
PHE A 888
LEU A 908
 None
 1.23A 1wrkA-5lewA:
undetectable
1wrkB-5lewA:
1.1		 1wrkA-5lewA:
6.90
1wrkB-5lewA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 402
LEU A 329
ALA A 345
GLU A 348
 None
 0.73A 1xvaA-5lewA:
undetectable
1xvaB-5lewA:
undetectable		 1xvaA-5lewA:
15.05
1xvaB-5lewA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 8 ARG A 667
GLY A 383
GLY A 790
ALA A 788
ALA A 789
 None
 1.42A 2ej3A-5lewA:
undetectable		 2ej3A-5lewA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 SER A 129
ALA A 128
SER A 138
SER A 126
 SO4  A1011 (-2.7A)
None
SO4  A1011 (-2.8A)
None
 1.00A 2i91A-5lewA:
undetectable		 2i91A-5lewA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 SER A 129
ALA A 128
SER A 138
SER A 126
 SO4  A1011 (-2.7A)
None
SO4  A1011 (-2.8A)
None
 0.99A 2i91B-5lewA:
undetectable		 2i91B-5lewA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 426
ARG A 382
ASN A 593
LEU A 619
 None
None
SO4  A1005 ( 4.0A)
None
 1.13A 2nyrA-5lewA:
undetectable		 2nyrA-5lewA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 287
ALA A 290
LEU A  13
MET A 271
 None
 1.18A 2oaxA-5lewA:
undetectable		 2oaxA-5lewA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.07A 2ow9B-5lewA:
undetectable		 2ow9B-5lewA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.11A 2ozrC-5lewA:
undetectable		 2ozrC-5lewA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  48
GLU A  73
HIS A  16
HIS A 228
 ZN  A1003 ( 3.3A)
ZN  A1001 ( 2.2A)
ZN  A1002 (-3.3A)
ZN  A1003 (-3.1A)
 1.11A 2ozrD-5lewA:
undetectable		 2ozrD-5lewA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 381
GLY A 379
ILE A 396
ALA A 386
ASP A 423
 None
 1.27A 2vdvF-5lewA:
undetectable		 2vdvF-5lewA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 SER A 251
THR A 525
ILE A 526
THR A 529
 None
 0.92A 3bpxA-5lewA:
undetectable
3bpxB-5lewA:
undetectable		 3bpxA-5lewA:
10.98
3bpxB-5lewA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 800
GLU A 808
ASP A 856
 None
 0.83A 3bxoA-5lewA:
2.0		 3bxoA-5lewA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 800
GLU A 808
ASP A 856
 None
 0.80A 3bxoB-5lewA:
undetectable		 3bxoB-5lewA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 533
GLN A 245
HIS A 469
LEU A 250
 None
 1.09A 3ce6D-5lewA:
undetectable		 3ce6D-5lewA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 GLY A  39
VAL A  35
GLY A  65
THR A  62
 None
 0.79A 3ib2A-5lewA:
undetectable		 3ib2A-5lewA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 922
SER A 907
LEU A 926
SER A 929
 None
 1.42A 3ik6H-5lewA:
undetectable		 3ik6H-5lewA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 922
SER A 907
LEU A 926
SER A 929
 None
 1.36A 3iluH-5lewA:
undetectable		 3iluH-5lewA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 557
VAL A 299
TRP A 300
 None
 0.84A 3l8lC-5lewA:
undetectable
3l8lD-5lewA:
undetectable		 3l8lC-5lewA:
1.83
3l8lD-5lewA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 4 GLY A  53
GLU A  56
ASP A 574
ASP A  47
 None
 1.41A 3mb5A-5lewA:
2.0		 3mb5A-5lewA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 724
LEU A 700
LEU A 696
ILE A 775
 None
 0.89A 3u5kA-5lewA:
undetectable		 3u5kA-5lewA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 724
LEU A 700
LEU A 696
ILE A 775
 None
 0.90A 3u5kC-5lewA:
undetectable		 3u5kC-5lewA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 724
LEU A 700
LEU A 696
ILE A 775
 None
 0.92A 3u5kD-5lewA:
undetectable		 3u5kD-5lewA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 THR A 116
ASN A 114
GLU A 150
 None
 0.78A 3v4tA-5lewA:
undetectable
3v4tC-5lewA:
undetectable		 3v4tA-5lewA:
20.04
3v4tC-5lewA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  82
LEU A 144
GLU A 143
SER A  80
 None
 1.20A 3vlnA-5lewA:
undetectable		 3vlnA-5lewA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 263
HIS A  14
HIS A 107
HIS A 198
 None
ZN  A1002 (-3.2A)
ZN  A1001 ( 3.1A)
None
 1.38A 3zodA-5lewA:
undetectable		 3zodA-5lewA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 822
LYS A 821
ASP A 820
 None
 0.78A 4a7tA-5lewA:
undetectable		 4a7tA-5lewA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.10A 4aftA-5lewA:
0.0
4aftB-5lewA:
0.0		 4aftA-5lewA:
13.04
4aftB-5lewA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_B_QMRB301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.18A 4aftB-5lewA:
0.0
4aftC-5lewA:
0.0		 4aftB-5lewA:
13.04
4aftC-5lewA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 547
MET A 586
ILE A 424
VAL A 435
TYR A 370
 None
 1.16A 4aftA-5lewA:
0.0
4aftE-5lewA:
0.0		 4aftA-5lewA:
13.04
4aftE-5lewA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 469
LEU A  22
LEU A 536
ASP A  23
 None
None
None
ZN  A1003 (-2.5A)
 1.12A 4aqlA-5lewA:
4.7		 4aqlA-5lewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 193
VAL A 279
GLY A 281
ALA A 282
SER A 285
 None
 1.07A 4coxC-5lewA:
0.3		 4coxC-5lewA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 517
ILE A 526
LEU A 462
ILE A 481
 None
 0.85A 4dtaB-5lewA:
undetectable		 4dtaB-5lewA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 802
LEU A 627
ALA A 799
 None
 0.82A 4iizA-5lewA:
undetectable		 4iizA-5lewA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 SER A 100
TRP A 137
HIS A 107
SER A 160
 SO4  A1004 ( 4.9A)
None
ZN  A1001 ( 3.1A)
None
 1.24A 4k7gB-5lewA:
undetectable		 4k7gB-5lewA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 890
ALA A 913
VAL A 843
ASP A 842
PHE A 914
 None
 1.32A 4xp1A-5lewA:
undetectable		 4xp1A-5lewA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 438
TYR A 437
HIS A 323
PRO A 310
 None
 0.97A 4ze2A-5lewA:
2.9		 4ze2A-5lewA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.09A 5ainA-5lewA:
0.0
5ainB-5lewA:
0.0		 5ainA-5lewA:
13.12
5ainB-5lewA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.00A 5ainB-5lewA:
0.0
5ainC-5lewA:
0.0		 5ainB-5lewA:
13.12
5ainC-5lewA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_C_QMRC1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.15A 5ainC-5lewA:
0.0
5ainD-5lewA:
0.0		 5ainC-5lewA:
13.12
5ainD-5lewA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 435
TYR A 370
VAL A 547
MET A 586
ILE A 424
 None
 1.07A 5ainD-5lewA:
0.0
5ainE-5lewA:
0.0		 5ainD-5lewA:
13.12
5ainE-5lewA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 547
MET A 586
ILE A 424
VAL A 435
TYR A 370
 None
 1.01A 5ainA-5lewA:
0.0
5ainE-5lewA:
0.0		 5ainA-5lewA:
13.12
5ainE-5lewA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 599
ASN A 593
PHE A 426
 None
SO4  A1005 ( 4.0A)
None
 0.76A 5dsgB-5lewA:
undetectable		 5dsgB-5lewA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 164
ASP A 226
GLY A 157
THR A 109
 None
ZN  A1002 (-2.5A)
None
None
 0.98A 5hwaA-5lewA:
undetectable		 5hwaA-5lewA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 192
PRO A 221
THR A 156
ILE A 219
 None
 1.13A 5ih0A-5lewA:
undetectable		 5ih0A-5lewA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 470
THR A 529
ARG A 524
ILE A 517
 None
 0.94A 5jhdE-5lewA:
undetectable
5jhdG-5lewA:
undetectable		 5jhdE-5lewA:
12.75
5jhdG-5lewA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 228
ASP A  23
HIS A  48
 ZN  A1003 (-3.1A)
ZN  A1003 (-2.5A)
ZN  A1003 ( 3.3A)
 0.76A 5oexA-5lewA:
undetectable		 5oexA-5lewA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 228
ASP A  23
HIS A  48
 ZN  A1003 (-3.1A)
ZN  A1003 (-2.5A)
ZN  A1003 ( 3.3A)
 0.68A 5oexB-5lewA:
undetectable		 5oexB-5lewA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 228
ASP A  23
HIS A  48
 ZN  A1003 (-3.1A)
ZN  A1003 (-2.5A)
ZN  A1003 ( 3.3A)
 0.67A 5oexC-5lewA:
undetectable		 5oexC-5lewA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 228
ASP A  23
HIS A  48
 ZN  A1003 (-3.1A)
ZN  A1003 (-2.5A)
ZN  A1003 ( 3.3A)
 0.65A 5oexD-5lewA:
undetectable		 5oexD-5lewA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 516
ILE A 481
TYR A 470
 None
 0.61A 5uunB-5lewA:
undetectable		 5uunB-5lewA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 657
ALA A 789
GLY A 792
TYR A 796
 None
 0.54A 5uxdA-5lewA:
undetectable		 5uxdA-5lewA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 794
SER A 795
THR A 798
PHE A 656
VAL A 660
 None
None
SO4  A1012 ( 4.9A)
None
None
 1.44A 6drxA-5lewA:
undetectable		 6drxA-5lewA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		5 / 9 SER A  60
PHE A  57
GLU A  56
VAL A  43
ASN A  15
 None
 1.25A 6ftpA-5lewA:
undetectable
6ftpB-5lewA:
undetectable		 6ftpA-5lewA:
6.39
6ftpB-5lewA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  35
PHE A  52
MET A  51
GLY A  49
 None
SO4  A1011 (-4.8A)
None
None
 1.35A 6hd4A-5lewA:
undetectable		 6hd4A-5lewA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5lew DNA POLYMERASE III
SUBUNIT ALPHA
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 811
GLY A 812
GLY A 847
ASN A 603
 None
 0.86A 6nm4A-5lewA:
undetectable		 6nm4A-5lewA:
11.39