SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 8 SER A 472
PHE A 444
SER A 419
ILE A 415
 None
 1.11A 1gm7A-5lf5A:
undetectable
1gm7B-5lf5A:
undetectable		 1gm7A-5lf5A:
16.19
1gm7B-5lf5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.23A 2hrcA-5lf5A:
undetectable		 2hrcA-5lf5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 8 PHE A  61
VAL A  73
ILE A  40
VAL A  38
 None
 0.65A 3hjoB-5lf5A:
undetectable		 3hjoB-5lf5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		3 / 3 PRO A 183
LEU A 202
HIS A 213
 None
 0.69A 4pevA-5lf5A:
undetectable		 4pevA-5lf5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 7 LEU A 377
VAL A 331
GLN A 374
GLU A 372
 None
 1.00A 5tudA-5lf5A:
undetectable		 5tudA-5lf5A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		3 / 3 GLU A  34
LEU A 107
ARG A  88
 None
 0.73A 6d8fA-5lf5A:
undetectable		 6d8fA-5lf5A:
21.42