SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 12 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.35A 1db1A-5lf8A:
undetectable		 1db1A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 11 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.01A 1h9zA-5lf8A:
undetectable		 1h9zA-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 11 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.00A 1ha2A-5lf8A:
undetectable		 1ha2A-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 12 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.31A 1ie9A-5lf8A:
undetectable		 1ie9A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		3 / 3 ARG A 277
THR A 270
TRP A 174
 PO4  A 401 (-2.7A)
None
None
 1.20A 4d7hA-5lf8A:
undetectable		 4d7hA-5lf8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		3 / 3 VAL A 278
SER A 279
THR A 282
 None
PO4  A 401 (-3.7A)
None
 0.35A 4luhA-5lf8A:
undetectable		 4luhA-5lf8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		3 / 3 ARG A 277
THR A 270
TRP A 174
 PO4  A 401 (-2.7A)
None
None
 1.26A 4ug5A-5lf8A:
undetectable		 4ug5A-5lf8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		3 / 3 ARG A 277
THR A 270
TRP A 174
 PO4  A 401 (-2.7A)
None
None
 1.17A 4uglA-5lf8A:
undetectable		 4uglA-5lf8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		3 / 3 ARG A 277
THR A 270
TRP A 174
 PO4  A 401 (-2.7A)
None
None
 1.24A 5g6cA-5lf8A:
undetectable		 5g6cA-5lf8A:
19.42