SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 4 ILE A  95
MET A 183
VAL A 139
GLY A 201
 None
 1.27A 1e06B-5lfdA:
undetectable		 1e06B-5lfdA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 6 ALA A  41
GLU A  42
LEU A 147
LEU A 116
 None
 0.92A 1mt1D-5lfdA:
undetectable
1mt1E-5lfdA:
undetectable		 1mt1D-5lfdA:
18.99
1mt1E-5lfdA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 8 MET A 183
SER A 142
ALA A 156
ILE A 160
 None
 1.10A 1pnlA-5lfdA:
undetectable
1pnlB-5lfdA:
undetectable		 1pnlA-5lfdA:
21.88
1pnlB-5lfdA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A 129
GLU A  97
THR A 219
TYR A 225
 None
 1.34A 1qvuA-5lfdA:
undetectable		 1qvuA-5lfdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		3 / 3 LYS A   1
ARG A 214
VAL A 213
 None
 0.93A 2r2vC-5lfdA:
undetectable
2r2vD-5lfdA:
undetectable		 2r2vC-5lfdA:
9.92
2r2vD-5lfdA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 11 ILE A  18
ALA A 184
MET A 144
GLU A  45
LEU A 149
 None
 1.24A 2v0mA-5lfdA:
undetectable		 2v0mA-5lfdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 11 ILE A  18
ALA A 184
MET A 144
GLU A  45
LEU A 149
 None
 1.26A 2v0mD-5lfdA:
undetectable		 2v0mD-5lfdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 SER A 111
GLN A 163
ALA A 164
THR A 194
ILE A 168
 None
 1.21A 3a35A-5lfdA:
undetectable		 3a35A-5lfdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 SER A 111
GLN A 163
ALA A 164
THR A 194
ILE A 168
 None
 1.18A 3a3bA-5lfdA:
undetectable		 3a3bA-5lfdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 6 GLU A  78
GLU A  49
ALA A  53
ASN A   9
 None
 1.07A 3pgyA-5lfdA:
undetectable
3pgyB-5lfdA:
2.6		 3pgyA-5lfdA:
22.03
3pgyB-5lfdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 11 THR A 102
PHE A 105
SER A 101
LEU A 212
VAL A  93
 None
 1.39A 3u9fN-5lfdA:
undetectable
3u9fO-5lfdA:
undetectable		 3u9fN-5lfdA:
18.82
3u9fO-5lfdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 181
GLN A  73
ILE A  18
LEU A 178
VAL A 202
 None
 1.27A 4azwA-5lfdA:
undetectable		 4azwA-5lfdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  18
THR A  17
THR A 114
GLU A  45
GLU A  49
 None
 1.37A 4i41A-5lfdA:
undetectable		 4i41A-5lfdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 11 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.02A 4j6cA-5lfdA:
undetectable		 4j6cA-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.01A 4j6cB-5lfdA:
undetectable		 4j6cB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.04A 4j6dA-5lfdA:
undetectable		 4j6dA-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.02A 4j6dB-5lfdA:
undetectable		 4j6dB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.04A 4jbtA-5lfdA:
undetectable		 4jbtA-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		5 / 11 ALA A  99
ALA A  98
ALA A 204
THR A 207
VAL A  25
 None
 1.03A 4jbtB-5lfdA:
undetectable		 4jbtB-5lfdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 5 SER A  50
GLY A  83
THR A 224
GLU A  86
 None
 1.02A 5btiC-5lfdA:
undetectable
5btiD-5lfdA:
3.2		 5btiC-5lfdA:
19.22
5btiD-5lfdA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		3 / 3 SER A 142
ALA A 141
THR A 119
 None
 0.71A 5n0xB-5lfdA:
2.6		 5n0xB-5lfdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		4 / 9 TYR A 110
ILE A 176
ILE A 190
LEU A 186
 None
 0.74A 5vkqB-5lfdA:
undetectable
5vkqC-5lfdA:
undetectable		 5vkqB-5lfdA:
9.24
5vkqC-5lfdA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		3 / 3 MET A 144
ASP A 152
ARG A 193
 None
 1.13A 5z6jA-5lfdA:
undetectable		 5z6jA-5lfdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lfd ALLANTOIN RACEMASE
(Pseudomonas
fluorescens) 		3 / 3 MET A 144
ASP A 152
ARG A 193
 None
 1.15A 5z6kA-5lfdA:
undetectable		 5z6kA-5lfdA:
17.34