SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		6 / 11 ILE A  46
LEU A  58
LEU A 106
VAL A  49
MET A  74
LEU A 104
 None
 1.23A 1dtlA-5lfnA:
undetectable		 1dtlA-5lfnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 8 GLN A 153
LEU A 130
LEU A 138
LEU A 183
 None
 1.08A 1hk2A-5lfnA:
undetectable		 1hk2A-5lfnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 8 ASN A 205
LEU A 186
ALA A 190
LEU A 191
 None
 0.95A 1hwiB-5lfnA:
undetectable		 1hwiB-5lfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 8 ASN A 205
LEU A 186
ALA A 190
LEU A 191
 None
 0.92A 1hwiC-5lfnA:
undetectable		 1hwiC-5lfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 7 GLN A  59
LEU A  66
SER A 107
ASN A 109
 None
 1.19A 1ig3A-5lfnA:
undetectable
1ig3B-5lfnA:
undetectable		 1ig3A-5lfnA:
21.04
1ig3B-5lfnA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 PHE A  95
LEU A  66
LEU A  58
LEU A  56
MET A  74
 None
 1.28A 1p33B-5lfnA:
undetectable		 1p33B-5lfnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 PHE A  95
LEU A  66
LEU A  58
LEU A  56
MET A  74
 None
 1.29A 1p33C-5lfnA:
undetectable		 1p33C-5lfnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 11 LEU A 149
ASN A 181
ILE A 159
LEU A 138
PHE A 167
 None
 1.22A 1tw4A-5lfnA:
undetectable		 1tw4A-5lfnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 114
LEU A  66
ALA A  94
LEU A  80
LEU A 125
 None
 1.37A 2oaxD-5lfnA:
undetectable		 2oaxD-5lfnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 114
LEU A  66
ALA A  94
LEU A  80
LEU A 125
 None
 1.38A 2oaxE-5lfnA:
undetectable		 2oaxE-5lfnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 11 LEU A 128
PHE A 119
LEU A 143
LEU A 162
VAL A 135
 None
 1.22A 2po5B-5lfnA:
undetectable		 2po5B-5lfnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 246
PHE A 239
SER A 227
LEU A 226
ILE A 234
 None
 1.13A 2w3vA-5lfnA:
undetectable		 2w3vA-5lfnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		3 / 3 LEU A 173
VAL A 221
ARG A 174
 None
 0.82A 3b0wB-5lfnA:
undetectable		 3b0wB-5lfnA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 7 LEU A 275
LEU A 283
ASN A 300
THR A 305
 None
 1.06A 3lm8B-5lfnA:
undetectable
3lm8D-5lfnA:
undetectable		 3lm8B-5lfnA:
21.97
3lm8D-5lfnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 9 PHE A 259
LEU A 249
THR A 248
VAL A 273
LEU A 256
 None
 1.19A 3tbgD-5lfnA:
undetectable		 3tbgD-5lfnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 128
PHE A 119
LEU A 149
ILE A 111
VAL A 194
 None
 1.27A 3w1wA-5lfnA:
undetectable		 3w1wA-5lfnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 128
PHE A 119
LEU A 149
ILE A 111
VAL A 194
 None
 1.28A 3w1wB-5lfnA:
undetectable		 3w1wB-5lfnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 7 TRP A 302
ASN A 278
LEU A 256
PHE A 287
 None
 1.17A 4awuA-5lfnA:
undetectable		 4awuA-5lfnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 251
LEU A 275
LEU A 295
ILE A 234
VAL A 267
 None
 0.98A 4f4dB-5lfnA:
undetectable		 4f4dB-5lfnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 10 LEU A 251
LEU A 275
LEU A 295
ILE A 234
VAL A 267
 None
 1.03A 4mk4A-5lfnA:
undetectable		 4mk4A-5lfnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		4 / 7 ASN A 157
TYR A 129
TYR A 105
LEU A  82
 None
 1.22A 4yv5A-5lfnA:
undetectable		 4yv5A-5lfnA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A  82
LEU A 101
VAL A  90
ALA A  94
SER A  70
 None
 1.07A 5jvzA-5lfnA:
undetectable		 5jvzA-5lfnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		3 / 3 HIS A 108
ASP A 131
HIS A 132
 None
 0.90A 5n1tW-5lfnA:
undetectable		 5n1tW-5lfnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 LEU A 275
LEU A 297
ALA A 296
LEU A 292
LEU A 270
 None
 0.97A 5toaA-5lfnA:
undetectable		 5toaA-5lfnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		5 / 12 VAL A  90
GLY A  93
ALA A 118
LEU A 128
LEU A 106
 None
 1.06A 5xxiA-5lfnA:
undetectable		 5xxiA-5lfnA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5lfn CHONDROADHERIN
(Homo
sapiens) 		3 / 3 GLN A 153
TYR A 177
ASN A 155
 None
 0.80A 6dwdC-5lfnA:
undetectable		 6dwdC-5lfnA:
20.98