SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.32A 1hrkB-5lfrA:
undetectable		 1hrkB-5lfrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 6 PRO A 162
PHE A  61
LEU A 111
ILE A 137
 None
 1.15A 1sbrA-5lfrA:
undetectable
1sbrB-5lfrA:
undetectable		 1sbrA-5lfrA:
19.75
1sbrB-5lfrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		5 / 11 GLU A 209
ALA A 210
ASP A 235
PRO A 206
PHE A 204
 None
 1.34A 2admA-5lfrA:
undetectable		 2admA-5lfrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.28A 2hrcA-5lfrA:
undetectable		 2hrcA-5lfrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.30A 2hrcB-5lfrA:
undetectable		 2hrcB-5lfrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.29A 2pnjB-5lfrA:
undetectable		 2pnjB-5lfrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 7 PHE A 221
LEU A 172
ALA A 219
PHE A 228
 None
 1.07A 2vcvL-5lfrA:
undetectable		 2vcvL-5lfrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		5 / 10 LEU A 290
LEU A 292
SER A 321
LEU A 320
LEU A 259
 None
 1.11A 2xn7A-5lfrA:
undetectable
2xn7B-5lfrA:
undetectable		 2xn7A-5lfrA:
23.69
2xn7B-5lfrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 8 ASN A 266
LYS A 237
PRO A 206
PHE A 204
 None
 1.17A 3bjwD-5lfrA:
undetectable		 3bjwD-5lfrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		5 / 10 VAL A 249
LEU A 292
VAL A 295
VAL A 257
LEU A 259
 NAG  A 408 (-4.4A)
None
None
NAG  A 408 ( 4.4A)
None
 0.99A 3gwxA-5lfrA:
undetectable		 3gwxA-5lfrA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 8 PHE A  61
VAL A  73
ILE A  40
VAL A  38
 None
 0.68A 3hjoB-5lfrA:
undetectable		 3hjoB-5lfrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		3 / 3 HIS A  56
PHE A  46
PHE A  44
 None
 0.72A 3lk0D-5lfrA:
undetectable		 3lk0D-5lfrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		3 / 3 PRO A  27
SER A  28
SER A 133
 None
 0.63A 6bpyA-5lfrA:
undetectable		 6bpyA-5lfrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN
(Mus
musculus) 		4 / 7 ILE A  40
LEU A 102
THR A  36
LEU A 107
 None
 0.96A 6nmpA-5lfrA:
undetectable
6nmpJ-5lfrA:
undetectable		 6nmpA-5lfrA:
21.04
6nmpJ-5lfrA:
11.59