SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 5 PHE A 122
TYR A  93
LEU A 179
VAL A 128
 None
 1.40A 1dz6A-5lgdA:
undetectable		 1dz6A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 9 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.46A 1iwjA-5lgdA:
undetectable		 1iwjA-5lgdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 10 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.42A 1o76A-5lgdA:
undetectable		 1o76A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 7 ARG A 273
ASN A 306
PHE A 312
TYR A 276
 None
 1.48A 1tdnA-5lgdA:
undetectable		 1tdnA-5lgdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 9 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.42A 2a1nB-5lgdA:
undetectable		 2a1nB-5lgdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 7 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.44A 2cppA-5lgdA:
undetectable		 2cppA-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.32A 2g70A-5lgdA:
undetectable		 2g70A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.35A 2g70B-5lgdA:
undetectable		 2g70B-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.41A 2g72A-5lgdA:
undetectable		 2g72A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 7 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.45A 4cp4A-5lgdA:
undetectable		 4cp4A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 6 LEU A 416
LEU A 387
ILE A 271
THR A 369
 None
PLM  A 513 ( 4.4A)
PLM  A 513 ( 4.6A)
PLM  A 513 (-3.9A)
 0.91A 4do3B-5lgdA:
undetectable		 4do3B-5lgdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 7 ASN A 390
PRO A 412
PHE A  68
PHE A 201
 None
None
None
PLM  A 512 (-4.9A)
 1.49A 4v32A-5lgdA:
undetectable		 4v32A-5lgdA:
14.04