SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5lgk IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		5 / 12 THR A 493
PRO A 495
ILE A 474
VAL A 476
VAL A 505
 None
 1.20A 1z9hD-5lgkA:
undetectable		 1z9hD-5lgkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5lgk IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		4 / 5 GLN A 538
THR A 536
ARG A 525
ALA A 526
 None
 1.42A 2qhfA-5lgkA:
undetectable		 2qhfA-5lgkA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 VAL E 281
TRP E 184
TRP E 220
 None
 1.25A 2xdcA-5lgkE:
undetectable
2xdcB-5lgkE:
undetectable		 2xdcA-5lgkE:
8.25
2xdcB-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.26A 2xdcA-5lgkE:
undetectable
2xdcB-5lgkE:
undetectable		 2xdcA-5lgkE:
8.25
2xdcB-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 VAL E 281
TRP E 184
TRP E 220
 None
 1.37A 2xdcC-5lgkE:
undetectable
2xdcD-5lgkE:
undetectable		 2xdcC-5lgkE:
8.25
2xdcD-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.03A 2xdcC-5lgkE:
undetectable
2xdcD-5lgkE:
undetectable		 2xdcC-5lgkE:
8.25
2xdcD-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.07A 2xdcE-5lgkE:
undetectable
2xdcF-5lgkE:
undetectable		 2xdcE-5lgkE:
8.25
2xdcF-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 VAL E 281
TRP E 184
TRP E 220
 None
 1.24A 2y5mA-5lgkE:
undetectable
2y5mB-5lgkE:
undetectable		 2y5mA-5lgkE:
8.25
2y5mB-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.05A 2y5mE-5lgkE:
undetectable
2y5mF-5lgkE:
undetectable		 2y5mE-5lgkE:
8.25
2y5mF-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 VAL E 281
TRP E 184
TRP E 220
 None
 1.24A 2y6nA-5lgkE:
undetectable
2y6nB-5lgkE:
undetectable		 2y6nA-5lgkE:
8.25
2y6nB-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.25A 2y6nA-5lgkE:
undetectable
2y6nB-5lgkE:
undetectable		 2y6nA-5lgkE:
8.25
2y6nB-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.03A 2y6nC-5lgkE:
undetectable
2y6nD-5lgkE:
undetectable		 2y6nC-5lgkE:
8.25
2y6nD-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 281
TRP E 184
 None
 1.03A 2y6nE-5lgkE:
undetectable
2y6nF-5lgkE:
undetectable		 2y6nE-5lgkE:
8.25
2y6nF-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5lgk IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		4 / 5 ILE A 474
SER A 475
PRO A 345
PHE A 346
 None
 1.27A 3bjwC-5lgkA:
undetectable		 3bjwC-5lgkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 VAL E 281
TRP E 184
TRP E 220
 None
 1.28A 3zq8A-5lgkE:
undetectable
3zq8B-5lgkE:
undetectable		 3zq8A-5lgkE:
8.25
3zq8B-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 220
VAL E 199
TRP E 184
 None
 0.91A 3zq8C-5lgkE:
undetectable
3zq8D-5lgkE:
undetectable		 3zq8C-5lgkE:
8.25
3zq8D-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens) 		4 / 5 TYR E 175
THR E 211
PHE E 177
ILE E 201
 None
 1.14A 4jx1E-5lgkE:
undetectable		 4jx1E-5lgkE:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5lgk IG EPSILON CHAIN C
REGION
LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP A 409
SER A 378
TYR E 189
 None
 0.87A 5glmA-5lgkA:
undetectable		 5glmA-5lgkA:
21.78