SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		7 / 9 THR A  26
TYR A  68
HIS A 181
HIS A 184
TYR A 186
LEU A 275
TYR A 351
 IPA  A 405 ( 3.4A)
IPA  A 405 (-4.5A)
FMN  A 401 (-3.8A)
IPA  A 402 ( 3.5A)
None
IPA  A 402 ( 4.1A)
FMN  A 401 ( 4.0A)
 0.25A 1h60A-5lgxA:
68.1		 1h60A-5lgxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 11 GLU A 272
HIS A 269
ALA A  23
GLY A 323
ARG A 286
 None
None
FMN  A 401 (-3.3A)
FMN  A 401 (-3.5A)
None
 1.28A 1l5rA-5lgxA:
2.2		 1l5rA-5lgxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		3 / 3 VAL A 167
ALA A 166
HIS A  75
 None
 0.62A 1q23G-5lgxA:
undetectable		 1q23G-5lgxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		3 / 3 VAL A 167
ALA A 166
HIS A  75
 None
 0.68A 1q23J-5lgxA:
undetectable		 1q23J-5lgxA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		7 / 9 THR A  26
TYR A  68
SER A 132
HIS A 181
HIS A 184
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
IPA  A 405 (-4.5A)
None
FMN  A 401 (-3.8A)
IPA  A 402 ( 3.5A)
None
FMN  A 401 ( 4.0A)
 0.59A 2abaA-5lgxA:
67.8		 2abaA-5lgxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 9 TYR A  68
ARG A 130
HIS A 181
HIS A 184
TYR A 186
 IPA  A 405 (-4.5A)
None
FMN  A 401 (-3.8A)
IPA  A 402 ( 3.5A)
None
 1.34A 2abaA-5lgxA:
67.8		 2abaA-5lgxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 8 ILE A 159
ARG A 149
LEU A 151
GLU A 155
 None
 0.87A 2cdqA-5lgxA:
undetectable		 2cdqA-5lgxA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 ILE A 230
GLY A 231
VAL A 178
LEU A 268
VAL A 218
 None
 0.97A 3fpjA-5lgxA:
undetectable		 3fpjA-5lgxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 ALA A 183
GLY A 185
LEU A 192
SER A 193
SER A 235
 None
 1.34A 3pfgA-5lgxA:
undetectable		 3pfgA-5lgxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 8 PRO A 236
HIS A 184
SER A 182
ILE A 232
 None
IPA  A 402 ( 3.5A)
None
None
 1.12A 3sfeB-5lgxA:
undetectable
3sfeC-5lgxA:
undetectable		 3sfeB-5lgxA:
21.56
3sfeC-5lgxA:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		6 / 9 THR A  26
ALA A  58
HIS A 181
HIS A 184
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.8A)
IPA  A 402 ( 3.5A)
None
FMN  A 401 ( 4.0A)
 0.30A 3upwA-5lgxA:
47.0		 3upwA-5lgxA:
36.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 7 THR A  26
HIS A 181
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
FMN  A 401 (-3.8A)
None
FMN  A 401 ( 4.0A)
 0.21A 4a3uA-5lgxA:
54.8		 4a3uA-5lgxA:
41.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 7 THR A  26
HIS A 181
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
FMN  A 401 (-3.8A)
None
FMN  A 401 ( 4.0A)
 0.22A 4a3uB-5lgxA:
54.9		 4a3uB-5lgxA:
41.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 5 VAL A 217
LEU A 180
LEU A 188
ILE A  61
 None
 0.93A 4a9jB-5lgxA:
undetectable		 4a9jB-5lgxA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		6 / 6 THR A  26
TYR A  68
HIS A 181
HIS A 184
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
IPA  A 405 (-4.5A)
FMN  A 401 (-3.8A)
IPA  A 402 ( 3.5A)
None
FMN  A 401 ( 4.0A)
 0.70A 4df2A-5lgxA:
47.0		 4df2A-5lgxA:
36.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 LEU A 268
ILE A 232
ILE A 257
ALA A 253
GLY A 185
 None
 1.14A 4enhA-5lgxA:
undetectable		 4enhA-5lgxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 7 LEU A  28
ARG A 142
THR A  26
THR A 131
GLY A  67
 None
None
IPA  A 405 ( 3.4A)
None
None
 1.35A 4eqlA-5lgxA:
undetectable		 4eqlA-5lgxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 6 ASN A 128
GLY A 185
PRO A 148
THR A 147
 None
 1.10A 4l1aB-5lgxA:
undetectable		 4l1aB-5lgxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 9 ALA A   2
LEU A 332
LEU A   5
ASN A  18
LEU A 336
 None
 1.38A 4x30A-5lgxA:
undetectable		 4x30A-5lgxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 5 HIS A 103
GLN A 190
ILE A 107
TYR A 186
 None
 1.45A 5fuqA-5lgxA:
1.3
5fuqB-5lgxA:
undetectable		 5fuqA-5lgxA:
21.24
5fuqB-5lgxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		3 / 3 ASP A 144
ASN A 242
GLN A 241
 None
 0.76A 5k7uA-5lgxA:
undetectable		 5k7uA-5lgxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 LEU A 260
ILE A 265
GLY A 264
LEU A 215
VAL A 218
 None
 1.15A 5twjC-5lgxA:
undetectable		 5twjC-5lgxA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 8 THR A  26
HIS A 181
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
FMN  A 401 (-3.8A)
None
FMN  A 401 ( 4.0A)
 0.25A 5v4vA-5lgxA:
49.2		 5v4vA-5lgxA:
39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		4 / 8 THR A  26
HIS A 181
TYR A 186
TYR A 351
 IPA  A 405 ( 3.4A)
FMN  A 401 (-3.8A)
None
FMN  A 401 ( 4.0A)
 0.23A 5v4vB-5lgxA:
49.2		 5v4vB-5lgxA:
39.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 10 TYR A 267
PHE A 293
ALA A 261
LEU A 180
CYH A 222
 None
 1.38A 6ay4A-5lgxA:
undetectable		 6ay4A-5lgxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 11 TYR A 186
SER A 132
THR A 131
TYR A 351
ALA A  71
 None
None
None
FMN  A 401 ( 4.0A)
None
 1.43A 6d6tD-5lgxA:
0.6
6d6tE-5lgxA:
0.6		 6d6tD-5lgxA:
22.41
6d6tE-5lgxA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 ILE A  86
TYR A  45
ILE A  54
PHE A 175
TYR A 351
 None
None
None
None
FMN  A 401 ( 4.0A)
 1.12A 6mkeA-5lgxA:
undetectable
6mkeD-5lgxA:
undetectable		 6mkeA-5lgxA:
13.49
6mkeD-5lgxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE
(Enterobacter
cloacae) 		5 / 12 ILE A  86
TYR A  45
ILE A  54
PHE A 175
TYR A 351
 None
None
None
None
FMN  A 401 ( 4.0A)
 1.11A 6mkeB-5lgxA:
undetectable
6mkeC-5lgxA:
undetectable		 6mkeB-5lgxA:
13.49
6mkeC-5lgxA:
13.49