SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 176
VAL A 148
TRP A 175
 None
 0.98A 1w5uA-5lheA:
undetectable
1w5uB-5lheA:
undetectable		 1w5uA-5lheA:
6.86
1w5uB-5lheA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 173
PHE A 201
VAL A  29
PHE A   4
 None
 1.16A 2ygnA-5lheA:
undetectable		 2ygnA-5lheA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 160
GLY A 170
VAL A   5
GLY A 208
VAL A 181
 None
 1.04A 3gguA-5lheA:
undetectable		 3gguA-5lheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A 160
GLY A 170
VAL A   5
GLY A 208
VAL A 181
 None
 1.05A 3nu9B-5lheA:
undetectable		 3nu9B-5lheA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 197
ILE A 198
GLY A 186
ILE A   7
 None
 0.85A 5dzk3-5lheA:
undetectable
5dzkm-5lheA:
undetectable		 5dzk3-5lheA:
1.67
5dzkm-5lheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.57A 5qgjA-5lheA:
undetectable		 5qgjA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.61A 5qgmA-5lheA:
undetectable		 5qgmA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.52A 5qgnA-5lheA:
undetectable		 5qgnA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.53A 5qgyA-5lheA:
undetectable		 5qgyA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.54A 5qgzA-5lheA:
undetectable		 5qgzA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.55A 5qh0A-5lheA:
undetectable		 5qh0A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.55A 5qh2A-5lheA:
undetectable		 5qh2A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.54A 5qh3A-5lheA:
undetectable		 5qh3A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.52A 5qh5A-5lheA:
undetectable		 5qh5A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.55A 5qh6A-5lheA:
undetectable		 5qh6A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.54A 5qh7A-5lheA:
undetectable		 5qh7A-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.59A 5qhaA-5lheA:
undetectable		 5qhaA-5lheA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A 129
VAL A 100
GLN A  79
 None
 0.54A 5qhhA-5lheA:
undetectable		 5qhhA-5lheA:
21.30