SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lhk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 GLY A 309
LEU A 243
THR A 244
VAL A 291
 None
 0.93A 1ekjF-5lhkA:
undetectable
1ekjG-5lhkA:
1.9		 1ekjF-5lhkA:
17.00
1ekjG-5lhkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 9 VAL A 371
GLY A 286
ALA A 485
THR A 482
ILE A 463
 None
 1.35A 1gtnL-5lhkA:
undetectable
1gtnM-5lhkA:
undetectable		 1gtnL-5lhkA:
9.98
1gtnM-5lhkA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 PHE A 411
LEU A 489
ALA A 485
PRO A 466
LEU A 382
 None
 1.16A 1kglA-5lhkA:
undetectable		 1kglA-5lhkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 10 LEU A 112
ALA A 160
ILE A 158
VAL A 167
ALA A 168
 None
 1.16A 1xp0A-5lhkA:
undetectable		 1xp0A-5lhkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 ALA A  97
ALA A  40
ALA A  95
GLY A 138
GLY A 134
 None
 0.88A 2igtA-5lhkA:
undetectable		 2igtA-5lhkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 ALA A  97
ALA A  40
ALA A  95
GLY A 138
GLY A 134
 None
 0.87A 2igtB-5lhkA:
undetectable		 2igtB-5lhkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 PHE A  58
ALA A 475
ALA A  91
THR A  89
GLY A  83
 None
 1.28A 2ve3B-5lhkA:
undetectable		 2ve3B-5lhkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 GLY A 262
ALA A 314
ALA A 290
VAL A 291
ASP A 284
 None
None
None
None
MN  A 601 (-2.2A)
 0.97A 2yvlD-5lhkA:
undetectable		 2yvlD-5lhkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 9 PRO A 312
VAL A 349
GLY A 226
ILE A 339
GLY A 346
 None
None
None
None
BCT  A 603 (-3.3A)
 1.43A 3csjB-5lhkA:
undetectable		 3csjB-5lhkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 GLY A 481
ASP A 182
ILE A 463
GLY A 287
PRO A 478
 None
 1.20A 3eeyD-5lhkA:
undetectable		 3eeyD-5lhkA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		6 / 12 GLY A  83
ARG A 111
GLY A  63
ALA A  96
ALA A  40
ASP A 113
 None
 1.35A 3sugA-5lhkA:
undetectable		 3sugA-5lhkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 ASP A 440
ALA A 445
PHE A 390
ASP A 284
ARG A 347
 None
None
None
MN  A 601 (-2.2A)
BCT  A 603 (-3.8A)
 1.31A 3wemA-5lhkA:
undetectable		 3wemA-5lhkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 7 ALA A 294
ALA A 485
ALA A 180
THR A 177
 None
 0.86A 4du2A-5lhkA:
undetectable		 4du2A-5lhkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 7 ALA A 294
ALA A 485
ALA A 180
THR A 177
 None
 0.85A 4du2B-5lhkA:
undetectable		 4du2B-5lhkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 LEU A  78
VAL A  38
ALA A 103
LEU A 112
LEU A 154
 None
 1.00A 4i1rA-5lhkA:
undetectable		 4i1rA-5lhkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 PHE A 196
GLY A 483
GLY A 481
LEU A 183
ALA A 293
 None
 0.98A 4krhA-5lhkA:
undetectable		 4krhA-5lhkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 ALA A 465
GLY A 387
GLU A 476
GLY A 483
PHE A 484
 None
 1.30A 4r29B-5lhkA:
0.6		 4r29B-5lhkA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 9 PHE A 196
ILE A 200
GLY A 262
LEU A 227
LEU A 219
 None
 1.34A 4ze0A-5lhkA:
undetectable		 4ze0A-5lhkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 ALA A 168
ARG A 300
ALA A 132
GLU A 175
 None
 1.39A 5a06C-5lhkA:
undetectable
5a06D-5lhkA:
undetectable		 5a06C-5lhkA:
21.76
5a06D-5lhkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 GLY A 483
PRO A 466
ALA A 464
LEU A 183
ALA A 293
 None
 1.21A 5bw4B-5lhkA:
undetectable		 5bw4B-5lhkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 8 ASN A 344
GLU A 420
HIS A 438
THR A 373
 BCT  A 603 (-4.0A)
None
None
None
 1.29A 5hqaA-5lhkA:
undetectable		 5hqaA-5lhkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 9 THR A 109
VAL A  39
ALA A  75
ASP A  72
SER A  70
 None
 1.38A 5l5fK-5lhkA:
0.0
5l5fL-5lhkA:
0.0		 5l5fK-5lhkA:
17.76
5l5fL-5lhkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 9 ALA A 283
ALA A 467
GLY A 481
ALA A 290
GLY A 483
 None
 1.16A 6bklE-5lhkA:
undetectable
6bklF-5lhkA:
undetectable
6bklG-5lhkA:
undetectable
6bklH-5lhkA:
undetectable		 6bklE-5lhkA:
4.79
6bklF-5lhkA:
4.79
6bklG-5lhkA:
4.79
6bklH-5lhkA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 12 GLY A 134
ARG A 102
THR A 482
GLY A 481
GLY A 480
 None
 1.10A 6brdB-5lhkA:
undetectable		 6brdB-5lhkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 LEU A 171
THR A 161
ARG A  94
ARG A 406
 None
 1.27A 6ew0B-5lhkA:
undetectable		 6ew0B-5lhkA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 LEU A 171
THR A 161
ARG A  94
ARG A 406
 None
 1.27A 6ew0D-5lhkA:
undetectable		 6ew0D-5lhkA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 LEU A 171
THR A 161
ARG A  94
ARG A 406
 None
 1.27A 6ew0H-5lhkA:
undetectable		 6ew0H-5lhkA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		4 / 5 LEU A 171
THR A 161
ARG A  94
ARG A 406
 None
 1.27A 6ew0I-5lhkA:
undetectable		 6ew0I-5lhkA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC
(Streptomyces
sp.
BC16019) 		5 / 10 VAL A 369
ALA A 459
LEU A 496
THR A 391
LEU A 489
 None
 0.77A 6f5uA-5lhkA:
undetectable
6f5uB-5lhkA:
undetectable		 6f5uA-5lhkA:
10.06
6f5uB-5lhkA:
8.58