SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_A_DVAA8_0 (GRAMICIDIN A)	5lhr	CAMELID-DERIVED ANTIBODY FRAGMENT NB22 (Vicugna pacos)	3 / 3	VAL B 48 TRP B 111 TRP B 109	None	0.86A	1c4dA-5lhrB: undetectable 1c4dB-5lhrB: undetectable	1c4dA-5lhrB: 5.76 1c4dB-5lhrB: 5.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_A_MTXA2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	5lhr	CAMELID-DERIVED ANTIBODY FRAGMENT NB22 (Vicugna pacos)	5 / 12	MET B 34 ARG B 72 ASN B 77 VAL B 79 ALA B 98	None	0.87A	3qxtA-5lhrB: 19.9	3qxtA-5lhrB: 76.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	5lhr	CAMELID-DERIVED ANTIBODY FRAGMENT NB22 (Vicugna pacos)	6 / 12	LEU B 4 ALA B 24 MET B 34 ARG B 72 VAL B 79 ALA B 98	None	0.83A	3qxtB-5lhrB: 20.0	3qxtB-5lhrB: 76.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_A_MTXA2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5lhr	CAMELID-DERIVED ANTIBODY FRAGMENT NB22 (Vicugna pacos)	6 / 12	MET B 34 ARG B 72 ASN B 74 VAL B 79 ALA B 98 TYR B 110	None	1.29A	3qxvA-5lhrB: 20.1	3qxvA-5lhrB: 76.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_C_MTXC2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5lhr	CAMELID-DERIVED ANTIBODY FRAGMENT NB22 (Vicugna pacos)	6 / 11	ALA B 24 MET B 34 ARG B 72 ASN B 74 VAL B 79 ALA B 98	None	0.89A	3qxvC-5lhrB: 20.2	3qxvC-5lhrB: 76.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C4D_A_DVAA8_0","GRAMICIDIN A","5lhr","CAMELID-DERIVED ANTIBODY FRAGMENT NB22","Vicugna pacos",3,"VAL B  48;TRP B 111;TRP B 109","None","0.86A","1c4dA-5lhrB:undetectable;1c4dB-5lhrB:undetectable","1c4dA-5lhrB:5.76;1c4dB-5lhrB:5.76"],["3QXT_A_MTXA2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","5lhr","CAMELID-DERIVED ANTIBODY FRAGMENT NB22","Vicugna pacos",5,"MET B  34;ARG B  72;ASN B  77;VAL B  79;ALA B  98","None","0.87A","3qxtA-5lhrB:19.9","3qxtA-5lhrB:76.80"],["3QXT_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","5lhr","CAMELID-DERIVED ANTIBODY FRAGMENT NB22","Vicugna pacos",6,"LEU B   4;ALA B  24;MET B  34;ARG B  72;VAL B  79;ALA B  98","None","0.83A","3qxtB-5lhrB:20.0","3qxtB-5lhrB:76.80"],["3QXV_A_MTXA2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","5lhr","CAMELID-DERIVED ANTIBODY FRAGMENT NB22","Vicugna pacos",6,"MET B  34;ARG B  72;ASN B  74;VAL B  79;ALA B  98;TYR B 110","None","1.29A","3qxvA-5lhrB:20.1","3qxvA-5lhrB:76.00"],["3QXV_C_MTXC2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","5lhr","CAMELID-DERIVED ANTIBODY FRAGMENT NB22","Vicugna pacos",6,"ALA B  24;MET B  34;ARG B  72;ASN B  74;VAL B  79;ALA B  98","None","0.89A","3qxvC-5lhrB:20.2","3qxvC-5lhrB:76.00"]]