SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 8 LEU B  97
VAL B 227
GLY B 226
MET B 180
 None
 0.93A 1hrkA-5lhsB:
undetectable		 1hrkA-5lhsB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 8 LEU B  97
VAL B 227
GLY B 226
MET B 180
 None
 0.92A 1hrkB-5lhsB:
undetectable		 1hrkB-5lhsB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 5 PHE B  30
GLY B  43
SER B 195
PHE B  40
 None
 1.38A 1icuC-5lhsB:
undetectable
1icuD-5lhsB:
undetectable		 1icuC-5lhsB:
18.92
1icuD-5lhsB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 GLY B  44
SER B  45
LEU B 209
ILE B  47
ILE B 108
 None
 1.17A 1kyvA-5lhsB:
undetectable
1kyvE-5lhsB:
undetectable		 1kyvA-5lhsB:
21.16
1kyvE-5lhsB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 ILE B 108
GLY B  44
SER B  45
LEU B 209
ILE B  47
 None
 1.17A 1kyvB-5lhsB:
undetectable
1kyvC-5lhsB:
undetectable		 1kyvB-5lhsB:
21.16
1kyvC-5lhsB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 ILE B 108
GLY B  44
SER B  45
LEU B 209
ILE B  47
 None
 1.15A 1kyvC-5lhsB:
undetectable
1kyvD-5lhsB:
undetectable		 1kyvC-5lhsB:
21.16
1kyvD-5lhsB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 ILE B 108
GLY B  44
SER B  45
LEU B 209
ILE B  47
 None
 1.12A 1kyvD-5lhsB:
undetectable
1kyvE-5lhsB:
undetectable		 1kyvD-5lhsB:
21.16
1kyvE-5lhsB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 5 HIS B 233
ARG B 230
ILE B 242
HIS B  91
 NI  B 303 (-3.9A)
None
None
None
 1.47A 1osvB-5lhsB:
undetectable		 1osvB-5lhsB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 8 PHE B  40
LEU B 155
TRP B 215
GLY B  44
 None
 0.97A 1rmtC-5lhsB:
undetectable		 1rmtC-5lhsB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 6 TRP B 215
ASN B 154
LEU B 155
PHE B  40
 None
 1.47A 1ru9H-5lhsB:
undetectable
1ru9L-5lhsB:
undetectable		 1ru9H-5lhsB:
22.18
1ru9L-5lhsB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 11 THR B 139
GLY B 140
PHE B 141
GLY B 196
PHE B  40
 None
 1.30A 2y7kA-5lhsB:
undetectable		 2y7kA-5lhsB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 GLY B 216
ASP B 194
GLY B 142
GLY B 196
LEU B 155
 None
 1.13A 3ku1G-5lhsB:
undetectable		 3ku1G-5lhsB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 4 GLY B  44
GLY B 197
THR B 139
LEU B 155
 None
 0.93A 3si7C-5lhsB:
undetectable
3si7D-5lhsB:
undetectable		 3si7C-5lhsB:
22.51
3si7D-5lhsB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		3 / 3 ASP B 102
GLY B 196
TYR B  99
 None
 0.75A 3w9tC-5lhsB:
undetectable		 3w9tC-5lhsB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		3 / 3 ASP B 102
GLY B 196
TYR B  99
 None
 0.74A 3w9tG-5lhsB:
undetectable		 3w9tG-5lhsB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 6 PHE B  59
ALA B 104
GLY B  44
LEU B 106
VAL B  52
 None
 1.27A 4dubA-5lhsB:
undetectable		 4dubA-5lhsB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 PHE B  40
LEU B  68
ILE B 108
GLY B 196
ALA B  31
 None
 1.15A 4enhA-5lhsB:
undetectable		 4enhA-5lhsB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 SER B 214
GLY B 196
ALA B  55
ASP B 102
THR B 229
 None
 1.31A 4xt8A-5lhsB:
undetectable		 4xt8A-5lhsB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 SER B 214
GLY B 196
ALA B  55
GLU B  96
THR B 229
 None
 1.19A 4xt8A-5lhsB:
undetectable		 4xt8A-5lhsB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 6 PRO B 170
GLU B 137
ALA B 221
TYR B 228
 None
 1.06A 5igiA-5lhsB:
undetectable		 5igiA-5lhsB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 4 LEU B  68
GLY B  69
SER B 117
SER B 115
 None
 1.24A 5uunA-5lhsB:
undetectable		 5uunA-5lhsB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 4 LEU B  68
GLY B  69
SER B 117
SER B 115
 None
 1.22A 5uunB-5lhsB:
undetectable		 5uunB-5lhsB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 PHE B  30
ILE B 212
VAL B 213
TRP B 215
VAL B  52
 None
 1.32A 6ap6A-5lhsB:
undetectable		 6ap6A-5lhsB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 12 PHE B  30
ILE B 212
VAL B 213
TRP B 215
VAL B  52
 None
 1.32A 6ap6B-5lhsB:
undetectable		 6ap6B-5lhsB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		3 / 3 TRP B  29
GLU B  25
GLU B 137
 None
 0.87A 6fhwA-5lhsB:
undetectable		 6fhwA-5lhsB:
14.88