SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5lhx SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		3 / 3 LYS A 658
SER A 691
GLN A 681
 None
 1.39A 3si7A-5lhxA:
undetectable		 3si7A-5lhxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5lhx SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		3 / 3 TYR A 685
PHE A 721
ARG A 726
 None
 1.22A 4g19D-5lhxA:
undetectable		 4g19D-5lhxA:
17.90