SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5li8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 213
ASP A 124
ASP A 220
 None
 0.90A 2br4D-5li8A:
undetectable		 2br4D-5li8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 393
GLY A 264
GLY A 403
GLU A 292
ALA A 268
 None
 1.10A 2plwA-5li8A:
undetectable		 2plwA-5li8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  12
ALA A  55
SER A   8
GLY A   6
ARG A  31
 None
 0.90A 2vmyB-5li8A:
undetectable		 2vmyB-5li8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 5 SER A 386
ARG A 412
PRO A 139
GLY A 140
 None
 1.32A 2y7kB-5li8A:
undetectable		 2y7kB-5li8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 6 SER A 386
ARG A 412
PRO A 139
GLY A 140
 None
 1.29A 2y7pA-5li8A:
undetectable		 2y7pA-5li8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 375
ASP A 125
LEU A 161
ARG A 374
 None
 1.41A 2ziaA-5li8A:
undetectable		 2ziaA-5li8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 265
ALA A 270
VAL A 389
ILE A 404
 None
 0.81A 3a2qA-5li8A:
undetectable		 3a2qA-5li8A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 158
LEU A 202
GLU A 256
PRO A 178
ARG A 259
 None
 0.83A 3eigA-5li8A:
undetectable		 3eigA-5li8A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 262
ILE A 149
GLY A 132
LEU A 126
ARG A 127
 None
 1.30A 3elzB-5li8A:
undetectable		 3elzB-5li8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 263
ILE A 262
ASN A 260
PRO A 154
 None
 1.02A 3fxrA-5li8A:
undetectable		 3fxrA-5li8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 290
PHE A 145
ARG A 259
ALA A 151
ALA A 263
 None
 1.32A 3lw5B-5li8A:
undetectable		 3lw5B-5li8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  94
PHE A 246
PHE A 251
VAL A 176
 None
KKK  A 502 (-4.7A)
None
None
 1.48A 3rv5C-5li8A:
1.2
3rv5D-5li8A:
0.9		 3rv5C-5li8A:
11.92
3rv5D-5li8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 225
PHE A 246
PHE A 251
VAL A 164
 None
KKK  A 502 (-4.7A)
None
None
 1.36A 3rv5C-5li8A:
1.2
3rv5D-5li8A:
0.9		 3rv5C-5li8A:
11.92
3rv5D-5li8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 220
ALA A 218
GLY A 212
ILE A 210
VAL A 164
 None
 1.08A 4dqcA-5li8A:
undetectable		 4dqcA-5li8A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 333
ARG A 295
ARG A 348
GLU A 271
 None
 0.98A 4kr4C-5li8A:
undetectable		 4kr4C-5li8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 385
GLY A 413
PRO A 139
LEU A 411
LEU A 381
 None
 1.12A 4x61A-5li8A:
undetectable		 4x61A-5li8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 376
GLY A 265
GLY A 264
ILE A 404
 None
 0.65A 4yjiA-5li8A:
undetectable		 4yjiA-5li8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 380
GLY A 265
GLY A 264
ILE A 404
 None
 0.73A 4yjiA-5li8A:
undetectable		 4yjiA-5li8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 255
HIS A 401
ASN A 260
ARG A 259
 None
 1.20A 5db5A-5li8A:
undetectable
5db5B-5li8A:
undetectable		 5db5A-5li8A:
23.76
5db5B-5li8A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 294
GLU A 291
LEU A  64
THR A  60
ARG A 348
 None
 1.39A 5hnxB-5li8A:
undetectable		 5hnxB-5li8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 119
GLY A 365
LEU A 250
LEU A 162
 None
HEM  A 501 (-3.3A)
KKK  A 502 ( 4.4A)
None
 0.76A 5hs1A-5li8A:
27.9		 5hs1A-5li8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 334
PRO A 335
PHE A 338
SER A 298
 None
 1.20A 5l1fC-5li8A:
undetectable		 5l1fC-5li8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 226
VAL A 225
GLU A 208
ARG A 201
PHE A 246
 None
None
None
None
KKK  A 502 (-4.7A)
 1.17A 5n5dA-5li8A:
undetectable		 5n5dA-5li8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 316
TRP A  52
VAL A 324
 None
 0.87A 6auuA-5li8A:
0.9		 6auuA-5li8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5li8 PUTATIVE CYTOCHROME
P450 126
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 405
ARG A 259
GLY A 403
ASN A 260
 None
 1.36A 6dwjB-5li8A:
undetectable
6dwjD-5li8A:
undetectable		 6dwjB-5li8A:
21.88
6dwjD-5li8A:
21.88