SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5liq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 LEU A 539
LEU A 545
LEU A 546
GLY A 424
PHE A 417
 None
 1.38A 1d4fB-5liqA:
undetectable		 1d4fB-5liqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 LEU A 539
LEU A 545
LEU A 546
GLY A 424
PHE A 417
 None
 1.45A 1d4fD-5liqA:
2.0		 1d4fD-5liqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 GLY A  96
LEU A  23
VAL A  73
PHE A  83
 None
 1.14A 1gsfA-5liqA:
undetectable		 1gsfA-5liqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 GLY A  96
LEU A  23
VAL A  73
PHE A  83
 None
 1.14A 1gsfB-5liqA:
undetectable		 1gsfB-5liqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 GLY A  96
LEU A  23
VAL A  73
PHE A  83
 None
 1.14A 1gsfD-5liqA:
undetectable		 1gsfD-5liqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 LEU A 144
PHE A 140
GLN A 168
ALA A 163
ARG A 203
 None
 1.49A 2noaA-5liqA:
undetectable		 2noaA-5liqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 7 ALA A 238
THR A 241
ALA A 240
TYR A   8
 None
 0.93A 2ql8A-5liqA:
undetectable
2ql8B-5liqA:
undetectable		 2ql8A-5liqA:
14.14
2ql8B-5liqA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 5 ARG A 313
PHE A 299
PHE A 301
LEU A 310
 None
 1.35A 3abmC-5liqA:
undetectable
3abmJ-5liqA:
undetectable		 3abmC-5liqA:
17.70
3abmJ-5liqA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		4 / 4 ILE A 576
GLN A 530
ILE A 585
LEU A 491
 None
 1.15A 3dzyD-5liqA:
undetectable		 3dzyD-5liqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 ASN A 347
ASP A 341
GLN A 337
 None
 0.79A 3eeyC-5liqA:
2.9		 3eeyC-5liqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 ASN A 347
ASP A 341
GLN A 337
 None
 0.79A 3eeyD-5liqA:
undetectable		 3eeyD-5liqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 ASN A 347
ASP A 341
GLN A 337
 None
 0.78A 3eeyE-5liqA:
3.4		 3eeyE-5liqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 ILE A 535
LEU A 545
VAL A 548
LEU A 559
ILE A 564
 None
 1.00A 3gwxB-5liqA:
undetectable		 3gwxB-5liqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 7 ILE A 268
ILE A 271
VAL A 139
LEU A 142
SER A 143
 None
 0.81A 3r9vA-5liqA:
undetectable
3r9vB-5liqA:
2.1		 3r9vA-5liqA:
20.67
3r9vB-5liqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 ARG A 103
GLU A  94
ARG A 104
 None
None
PO4  A 708 (-3.5A)
 0.94A 4mwvA-5liqA:
undetectable		 4mwvA-5liqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 ILE A 156
TRP A   7
THR A 241
LEU A 151
LEU A 144
 None
 1.42A 4pbhA-5liqA:
undetectable		 4pbhA-5liqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5liq NICKING ENDONUCLEASE
N.BSPD6I
(Bacillus
sp.
(in:
Bacteria)) 		5 / 11 VAL A   9
SER A  10
PRO A 137
TYR A  79
LEU A 113
 None
 1.33A 5jh7D-5liqA:
undetectable		 5jh7D-5liqA:
19.30