SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 11 ILE A  68
LEU A  67
GLY A  13
SER A  12
LEU A 104
 None
 1.39A 1kyvA-5lirA:
5.9
1kyvB-5lirA:
5.9		 1kyvA-5lirA:
19.68
1kyvB-5lirA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 12 ALA A 204
THR A 192
ILE A 208
GLY A 157
ALA A 198
 None
 1.01A 1utdO-5lirA:
undetectable
1utdP-5lirA:
undetectable		 1utdO-5lirA:
15.02
1utdP-5lirA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 11 ALA A 204
THR A 192
ILE A 208
GLY A 157
ALA A 198
 None
 1.02A 1utdP-5lirA:
undetectable
1utdQ-5lirA:
undetectable		 1utdP-5lirA:
15.02
1utdQ-5lirA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		4 / 6 VAL A 121
LYS A 125
GLN A 129
GLY A 131
 None
 1.01A 3bjwE-5lirA:
undetectable		 3bjwE-5lirA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		4 / 7 VAL A 217
ILE A   7
GLY A   8
LEU A 123
 None
 0.91A 3bjwH-5lirA:
undetectable		 3bjwH-5lirA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 10 MET A 127
ALA A 124
VAL A 120
ALA A 140
VAL A 215
 None
 1.23A 3f8fA-5lirA:
0.0
3f8fB-5lirA:
undetectable		 3f8fA-5lirA:
20.58
3f8fB-5lirA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 11 THR A 192
GLN A 199
GLY A 207
ALA A 204
ASP A 200
 None
 1.27A 3mg0H-5lirA:
undetectable
3mg0I-5lirA:
undetectable		 3mg0H-5lirA:
21.92
3mg0I-5lirA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 12 GLY A  13
GLY A  15
ARG A  64
ALA A  25
ALA A  43
 None
 1.12A 4kicA-5lirA:
3.7		 4kicA-5lirA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 11 THR A 192
GLN A 199
GLY A 207
ALA A 204
ASP A 200
 None
 1.29A 5bxnV-5lirA:
undetectable
5bxnW-5lirA:
undetectable		 5bxnV-5lirA:
21.03
5bxnW-5lirA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 9 THR A  28
VAL A   9
GLY A   8
VAL A 215
VAL A 212
 None
 1.42A 5cp4A-5lirA:
undetectable		 5cp4A-5lirA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		3 / 3 GLY A  19
ASP A  18
ASN A  53
 None
 0.61A 5jglA-5lirA:
undetectable		 5jglA-5lirA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		3 / 3 LYS A 188
ASP A 186
ILE A 181
 None
 0.86A 5kc4E-5lirA:
undetectable		 5kc4E-5lirA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 12 THR A 192
GLN A 199
GLY A 207
ALA A 204
ASP A 200
 None
 1.32A 5l5zH-5lirA:
undetectable
5l5zI-5lirA:
undetectable		 5l5zH-5lirA:
20.99
5l5zI-5lirA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 12 THR A 192
GLN A 199
GLY A 207
ALA A 204
ASP A 200
 None
 1.35A 5l5zV-5lirA:
undetectable
5l5zW-5lirA:
undetectable		 5l5zV-5lirA:
20.99
5l5zW-5lirA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)
(Salmonella
enterica) 		5 / 10 GLU A  24
GLY A  96
GLY A  97
ILE A 137
PRO A 141
 CSO  A 138 ( 2.9A)
CSO  A 138 ( 3.6A)
CSO  A 138 ( 3.8A)
CSO  A 138 ( 3.9A)
CSO  A 138 ( 4.1A)
 0.51A 6e5zA-5lirA:
18.8		 6e5zA-5lirA:
21.69