SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5liv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A 178
ALA A 179
LEU A 312
VAL A 305
ILE A 316
 None
 1.31A 1claA-5livA:
undetectable		 1claA-5livA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 6 LEU A 312
ILE A 372
ASP A 308
PRO A 309
 None
 0.87A 1ditH-5livA:
undetectable
1ditP-5livA:
undetectable		 1ditH-5livA:
19.33
1ditP-5livA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 LEU A  94
LEU A  58
ILE A 355
GLY A 328
LEU A 352
 None
 1.18A 1g50B-5livA:
undetectable		 1g50B-5livA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 11 LEU A  94
LEU A  58
ILE A 355
GLY A 328
LEU A 352
 None
 1.18A 1g50C-5livA:
2.1		 1g50C-5livA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 LEU A 404
LEU A 408
GLU A 317
ALA A 315
LEU A 311
 None
 1.32A 1ie4A-5livA:
undetectable
1ie4C-5livA:
undetectable		 1ie4A-5livA:
14.95
1ie4C-5livA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 THR A 283
PHE A 114
LEU A 330
PHE A  88
VAL A 213
 GOL  A 502 (-4.0A)
None
None
None
None
 1.21A 1q23H-5livA:
undetectable
1q23I-5livA:
undetectable		 1q23H-5livA:
19.12
1q23I-5livA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 5 LEU A 190
PRO A 183
VAL A 186
ILE A 187
 None
 1.02A 2aoiB-5livA:
undetectable		 2aoiB-5livA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 9 ILE A 372
ILE A 316
GLU A 317
ALA A 314
THR A 291
 None
 1.34A 2dtjA-5livA:
undetectable
2dtjB-5livA:
undetectable		 2dtjA-5livA:
18.22
2dtjB-5livA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 162
LEU A 443
LEU A 174
PHE A 178
LEU A 404
 None
SO4  A 508 (-4.0A)
None
None
None
 1.03A 2oipA-5livA:
undetectable		 2oipA-5livA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 162
LEU A 443
LEU A 174
PHE A 178
LEU A 404
 None
SO4  A 508 (-4.0A)
None
None
None
 1.00A 3hj3C-5livA:
undetectable		 3hj3C-5livA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 162
LEU A 443
LEU A 174
PHE A 178
LEU A 404
 None
SO4  A 508 (-4.0A)
None
None
None
 1.11A 3hj3D-5livA:
undetectable		 3hj3D-5livA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 8 ILE A 316
ALA A 400
THR A 284
ALA A 179
 None
None
HEM  A 501 (-3.9A)
None
 0.81A 3hrdA-5livA:
undetectable
3hrdB-5livA:
0.1		 3hrdA-5livA:
23.26
3hrdB-5livA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		3 / 3 GLU A 223
ASP A 217
ASP A 430
 None
 0.70A 3jb2A-5livA:
undetectable		 3jb2A-5livA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  69
ASN A 358
ALA A 356
ILE A  92
PHE A  59
 None
 1.39A 3t3qA-5livA:
28.5		 3t3qA-5livA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  69
ASN A 358
ALA A 356
ILE A  92
PHE A  59
 None
 1.45A 3t3qB-5livA:
28.5		 3t3qB-5livA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  69
ASN A 358
ALA A 356
ILE A  92
PHE A  59
 None
 1.43A 3t3qC-5livA:
28.6		 3t3qC-5livA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  69
ASN A 358
ALA A 356
ILE A  92
PHE A  59
 None
 1.44A 3t3qD-5livA:
28.7		 3t3qD-5livA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 7 ALA A 396
PRO A 394
GLU A 317
LEU A 287
 HEM  A 501 ( 3.7A)
None
None
HEM  A 501 ( 4.6A)
 0.88A 4iomA-5livA:
undetectable		 4iomA-5livA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 5 PHE A  88
TYR A 426
PHE A  69
ILE A  92
 None
 1.19A 4jx1E-5livA:
38.7		 4jx1E-5livA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 12 GLU A 151
SER A 159
LEU A 182
VAL A 163
LEU A 414
 None
 1.47A 4k36A-5livA:
undetectable		 4k36A-5livA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 11 GLU A 151
SER A 159
LEU A 182
VAL A 163
LEU A 414
 None
 1.50A 4k37A-5livA:
undetectable		 4k37A-5livA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 11 GLU A 151
SER A 159
LEU A 182
VAL A 163
LEU A 414
 None
 1.48A 4k37B-5livA:
undetectable		 4k37B-5livA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 ILE A 187
ALA A 195
PHE A 191
THR A 231
ILE A 277
 None
 1.26A 4km0A-5livA:
undetectable		 4km0A-5livA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		3 / 3 GLU A 203
TYR A 281
GLU A 282
 None
 0.74A 4ryaA-5livA:
undetectable		 4ryaA-5livA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 6 PHE A  60
ARG A  72
PHE A  59
HIS A 434
 None
 1.39A 4uciA-5livA:
undetectable		 4uciA-5livA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		3 / 3 VAL A 349
PHE A  88
ARG A 214
 None
 0.91A 4xr4B-5livA:
undetectable		 4xr4B-5livA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		6 / 12 GLY A 319
ILE A 372
VAL A 305
ILE A 292
LEU A 295
HIS A 298
 None
 1.25A 5wy0A-5livA:
undetectable		 5wy0A-5livA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		4 / 7 VAL A 432
PHE A 327
LEU A 330
GLY A 279
 None
None
None
GOL  A 502 ( 3.2A)
 0.79A 6eu9D-5livA:
2.1		 6eu9D-5livA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 10 VAL A 441
LEU A 414
LEU A 407
LEU A 295
LEU A 296
 None
 1.01A 6f6nA-5livA:
undetectable
6f6nB-5livA:
undetectable		 6f6nA-5livA:
10.79
6f6nB-5livA:
11.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 6 PHE A 114
LEU A 119
ALA A 124
SER A 275
THR A 283
 None
None
HEM  A 501 (-3.9A)
HEM  A 501 ( 3.8A)
GOL  A 502 (-4.0A)
 0.49A 6f88A-5livA:
67.0		 6f88A-5livA:
61.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1
(Sorangium
cellulosum) 		5 / 6 LEU A 119
ALA A 124
LEU A 209
SER A 275
THR A 283
 None
HEM  A 501 (-3.9A)
None
HEM  A 501 ( 3.8A)
GOL  A 502 (-4.0A)
 0.50A 6f88B-5livA:
68.2		 6f88B-5livA:
61.54