SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5liy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 11 ALA X 136
ALA X 141
VAL X 159
LEU X 170
GLN X 166
 None
 1.20A 1hbpA-5liyX:
undetectable		 1hbpA-5liyX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 8 SER X  23
SER X 264
ALA X  31
ILE X 270
 MLY  X 263 ( 3.2A)
NAP  X 401 (-2.5A)
None
None
 1.21A 1pnlA-5liyX:
undetectable
1pnlB-5liyX:
undetectable		 1pnlA-5liyX:
20.38
1pnlB-5liyX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 ALA X 136
ALA X 141
VAL X 159
LEU X 170
GLN X 166
 None
 1.21A 1rlbE-5liyX:
undetectable		 1rlbE-5liyX:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TRP X  80
HIS X 111
GLU X 186
TYR X 210
SER X 211
 None
DQP  X 402 ( 4.1A)
None
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
 0.26A 1s2aA-5liyX:
45.5		 1s2aA-5liyX:
46.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 6 ARG X 256
GLN X 193
GLU X 194
ILE X 197
 None
 1.04A 2fcnA-5liyX:
undetectable
2fcnB-5liyX:
undetectable		 2fcnA-5liyX:
15.29
2fcnB-5liyX:
15.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
 0.40A 2ineA-5liyX:
50.2		 2ineA-5liyX:
70.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
 0.46A 2isfA-5liyX:
49.9		 2isfA-5liyX:
70.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 GLU X  52
LEU X 109
ASP X 106
VAL X 154
ALA X 156
 None
None
None
MLZ  X 155 ( 3.0A)
MLZ  X 155 ( 3.0A)
 1.28A 2kceA-5liyX:
undetectable		 2kceA-5liyX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 11 GLU X  85
ASP X 140
LEU X  88
SER X 118
PHE X  83
 None
 1.45A 3ko0Q-5liyX:
undetectable
3ko0R-5liyX:
undetectable
3ko0S-5liyX:
undetectable
3ko0T-5liyX:
undetectable		 3ko0Q-5liyX:
15.61
3ko0R-5liyX:
15.61
3ko0S-5liyX:
15.61
3ko0T-5liyX:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.28A 3r43A-5liyX:
45.0		 3r43A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.38A 3r58A-5liyX:
43.9		 3r58A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.31A 3r6iA-5liyX:
43.7		 3r6iA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.43A 3r8gA-5liyX:
43.8		 3r8gA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.44A 3r94A-5liyX:
43.6		 3r94A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.09A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.70A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 7 TRP X  21
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.08A 3s3gA-5liyX:
50.4		 3s3gA-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 7 TRP X  21
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.79A 3s3gA-5liyX:
50.4		 3s3gA-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.03A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 9 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.63A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TRP X  80
ASN X 161
TYR X 210
SER X 211
SER X 215
 None
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
NAP  X 401 (-2.7A)
 0.83A 3ug8A-5liyX:
43.8		 3ug8A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		7 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
SER X 211
PRO X 311
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
None
 0.51A 3ug8A-5liyX:
43.8		 3ug8A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TRP X  80
HIS X 111
TYR X 210
SER X 211
SER X 215
 None
DQP  X 402 ( 4.1A)
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
NAP  X 401 (-2.7A)
 0.82A 3ugrA-5liyX:
44.2		 3ugrA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 7 TYR X  49
ASN X 161
GLU X 186
PRO X 311
 DQP  X 402 ( 4.0A)
NAP  X 401 (-3.2A)
None
None
 0.61A 3ugrA-5liyX:
44.2		 3ugrA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 8 TRP X  21
VAL X  48
TRP X  80
HIS X 111
PRO X 219
TRP X 220
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
None
DQP  X 402 ( 4.1A)
DQP  X 402 (-4.5A)
None
 0.69A 3v35A-5liyX:
50.8		 3v35A-5liyX:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 11 SER X   8
LEU X   7
ILE X 167
VAL X 107
VAL X 149
 None
 1.08A 3w67A-5liyX:
1.6		 3w67A-5liyX:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 8 VAL X  48
TYR X  49
TRP X  80
HIS X 111
 DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
 0.26A 4jtrA-5liyX:
45.4		 4jtrA-5liyX:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 6 VAL X  48
TYR X  49
TRP X  80
HIS X 111
 DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
 0.27A 4jtrB-5liyX:
45.5		 4jtrB-5liyX:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		3 / 3 ASP X  44
TRP X 220
SER X 160
 NAP  X 401 (-3.7A)
None
NAP  X 401 (-2.8A)
 1.08A 4lrhA-5liyX:
undetectable		 4lrhA-5liyX:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 THR X   9
LEU X   7
ALA X 156
GLN X 184
THR X 206
 None
None
MLZ  X 155 ( 3.0A)
NAP  X 401 (-3.8A)
EDO  X 403 (-4.6A)
 1.27A 4ltwA-5liyX:
undetectable		 4ltwA-5liyX:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TRP X  21
ARG X 125
TRP X 220
CYH X 299
LEU X 301
 DQP  X 402 ( 3.5A)
None
None
DQP  X 402 (-4.0A)
DQP  X 402 (-3.4A)
 1.23A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 10 TRP X  21
VAL X  48
PHE X 123
TRP X 220
CYH X 299
LEU X 301
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 (-3.7A)
None
DQP  X 402 (-4.0A)
DQP  X 402 (-3.4A)
 1.01A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		7 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
None
DQP  X 402 (-4.0A)
 0.51A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.31A 4yvvA-5liyX:
45.5		 4yvvA-5liyX:
46.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 PRO X 124
HIS X 111
TYR X 310
PHE X 312
 None
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.9A)
 1.38A 5igjA-5liyX:
undetectable		 5igjA-5liyX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		3 / 3 HIS X 188
SER X 211
ARG X 218
 None
NAP  X 401 (-2.8A)
None
 0.95A 5u63A-5liyX:
undetectable		 5u63A-5liyX:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 ILE X 205
LEU X  73
GLY X 158
LEU X   7
PHE X   4
 MLY  X 203 ( 4.7A)
None
None
None
None
 1.22A 6a7pA-5liyX:
undetectable		 6a7pA-5liyX:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 PHE X  74
LEU X  18
GLY X  19
VAL X   5
ILE X 259
 None
None
NAP  X 401 (-3.4A)
None
None
 1.22A 6bxnB-5liyX:
undetectable		 6bxnB-5liyX:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 6 TYR X 108
GLN X 184
GLU X  52
ALA X  92
 None
NAP  X 401 (-3.8A)
None
None
 1.20A 6djzB-5liyX:
undetectable		 6djzB-5liyX:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 6 ASP X  99
GLN X  50
LEU X 122
PHE X  83
 MLY  X  95 ( 2.7A)
None
None
None
 1.26A 6ekuA-5liyX:
undetectable		 6ekuA-5liyX:
18.50