SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.83A 1a7yA-5lj3L:
undetectable		 1a7yA-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.89A 1a7yB-5lj3L:
undetectable		 1a7yB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.86A 1a7yB-5lj3L:
undetectable		 1a7yB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.69A 1dscC-5lj3L:
undetectable		 1dscC-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.81A 1i3wE-5lj3L:
undetectable		 1i3wE-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.85A 1i3wF-5lj3L:
undetectable		 1i3wF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.87A 1i3wG-5lj3L:
undetectable		 1i3wG-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.80A 1i3wG-5lj3L:
undetectable		 1i3wG-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.80A 1i3wH-5lj3L:
undetectable		 1i3wH-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.81A 1mnvD-5lj3L:
undetectable		 1mnvD-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.80A 1mnvD-5lj3L:
undetectable		 1mnvD-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.83A 1qfiA-5lj3L:
undetectable		 1qfiA-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.86A 1qfiB-5lj3L:
undetectable		 1qfiB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.84A 1unjF-5lj3L:
undetectable		 1unjF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.82A 1unjL-5lj3L:
undetectable		 1unjL-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.77A 1unjL-5lj3L:
undetectable		 1unjL-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.80A 1unjR-5lj3L:
undetectable		 1unjR-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.79A 1unjR-5lj3L:
undetectable		 1unjR-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.73A 1unjW-5lj3L:
undetectable		 1unjW-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.79A 1unjX-5lj3L:
undetectable		 1unjX-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.77A 1unjX-5lj3L:
undetectable		 1unjX-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.77A 1unmE-5lj3L:
undetectable		 1unmE-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.75A 1unmE-5lj3L:
undetectable		 1unmE-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.84A 1unmF-5lj3L:
undetectable		 1unmF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.78A 1unmF-5lj3L:
undetectable		 1unmF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  22
THR L  24
PRO L  21
 None
 0.88A 209dC-5lj3L:
undetectable		 209dC-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 ARG J 312
VAL J 272
THR J 229
 None
 0.64A 2nmzA-5lj3J:
undetectable		 2nmzA-5lj3J:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		4 / 6 SER J 374
LYS J 383
GLU J 346
TYR J 376
 None
 0.99A 2x7hA-5lj3J:
undetectable		 2x7hA-5lj3J:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 CYH L 145
CYH L 108
HIS L 147
 ZN  L1002 (-2.6A)
ZN  L1002 ( 2.2A)
U  V  29 ( 4.2A)
 0.84A 3dtuB-5lj3L:
undetectable		 3dtuB-5lj3L:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 CYH L 145
CYH L 108
HIS L 147
 ZN  L1002 (-2.6A)
ZN  L1002 ( 2.2A)
U  V  29 ( 4.2A)
 0.83A 3dtuD-5lj3L:
undetectable		 3dtuD-5lj3L:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5lj3 PRE-MRNA-SPLICING
FACTOR SLT11
(Saccharomyces
cerevisiae) 		3 / 3 MET N  25
CYH N  73
PRO N  10
 None
 1.33A 3h52C-5lj3N:
undetectable		 3h52C-5lj3N:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 ASP J 408
PHE J 155
SER J 405
 None
 0.79A 3i5uB-5lj3J:
undetectable		 3i5uB-5lj3J:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 ARG J 312
VAL J 272
THR J 229
 None
 0.59A 3k4vD-5lj3J:
undetectable		 3k4vD-5lj3J:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 THR L  24
PRO L  21
THR L  22
 None
 0.84A 4hivD-5lj3L:
undetectable		 4hivD-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 LEU J 403
ARG J 186
ARG J 312
 None
 0.82A 4yiaB-5lj3J:
undetectable		 4yiaB-5lj3J:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		4 / 8 ALA L  87
HIS L  56
LEU L  91
LEU L  90
 None
None
None
C  U 122 ( 4.5A)
 1.17A 5dzkd-5lj3L:
undetectable
5dzkr-5lj3L:
undetectable		 5dzkd-5lj3L:
20.18
5dzkr-5lj3L:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		4 / 6 SER J 325
HIS J 307
LEU J 304
LEU J 341
 None
 1.28A 5dzke-5lj3J:
undetectable
5dzks-5lj3J:
undetectable		 5dzke-5lj3J:
18.28
5dzks-5lj3J:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 HIS J 382
GLU J 346
TRP J 442
 None
 0.90A 5odiD-5lj3J:
undetectable		 5odiD-5lj3J:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 HIS J 382
GLU J 346
TRP J 442
 None
 0.92A 5odqD-5lj3J:
undetectable		 5odqD-5lj3J:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		3 / 3 HIS J 382
GLU J 346
TRP J 442
 None
 0.92A 5odrD-5lj3J:
undetectable		 5odrD-5lj3J:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		4 / 8 HIS J 307
LEU J 356
THR J 314
ALA J 313
 None
 0.86A 5tt3H-5lj3J:
undetectable		 5tt3H-5lj3J:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5lj3 PRP46
(Saccharomyces
cerevisiae) 		5 / 12 MET J 301
VAL J 295
SER J 322
LEU J 316
VAL J 282
 None
 1.27A 5ubbA-5lj3J:
undetectable		 5ubbA-5lj3J:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 MET L  53
ASP L  88
ARG L 123
 None
None
A  V  26 ( 4.8A)
 1.15A 5z6jA-5lj3L:
undetectable		 5z6jA-5lj3L:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5lj3 PRE-MRNA-SPLICING
FACTOR BUD31
(Saccharomyces
cerevisiae) 		3 / 3 ARG L   7
LYS L   5
ARG L  31
 None
 1.33A 6c06D-5lj3L:
undetectable		 6c06D-5lj3L:
undetectable