SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 PHE A  89
SER A 153
PHE A  91
ALA A 157
 None
 1.01A 1fxvA-5lj6A:
undetectable
1fxvB-5lj6A:
undetectable		 1fxvA-5lj6A:
15.71
1fxvB-5lj6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 GLN A 338
VAL A 476
ALA A 481
SER A 484
 None
 0.97A 1p6kA-5lj6A:
undetectable		 1p6kA-5lj6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 532
GLY A 535
ILE A 277
SER A 281
SER A 617
 None
 1.14A 1ri4A-5lj6A:
undetectable		 1ri4A-5lj6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 11 THR A  71
GLU A  70
LEU A   9
ILE A  52
ASP A  57
 None
 1.36A 1t6zA-5lj6A:
undetectable		 1t6zA-5lj6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 LEU A 448
ALA A 364
LEU A 366
SER A 350
 None
 0.52A 1tyrB-5lj6A:
undetectable		 1tyrB-5lj6A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 LEU A 448
ALA A 364
LEU A 366
SER A 350
 None
 0.72A 1tz8C-5lj6A:
undetectable
1tz8D-5lj6A:
undetectable		 1tz8C-5lj6A:
10.86
1tz8D-5lj6A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 532
ILE A 527
ALA A 525
ILE A 279
SER A 281
 None
 0.90A 1ve3A-5lj6A:
undetectable		 1ve3A-5lj6A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 533
ILE A 527
ALA A 525
ILE A 279
SER A 281
 None
 1.11A 1ve3A-5lj6A:
undetectable		 1ve3A-5lj6A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ALA A 632
ALA A 633
ASN A 563
ALA A 640
LEU A 569
 None
 1.02A 2aclA-5lj6A:
undetectable
2aclE-5lj6A:
undetectable		 2aclA-5lj6A:
17.30
2aclE-5lj6A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.08A 2bm9D-5lj6A:
undetectable		 2bm9D-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.02A 2br4A-5lj6A:
undetectable		 2br4A-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.03A 2br4D-5lj6A:
undetectable		 2br4D-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.00A 2br4F-5lj6A:
undetectable		 2br4F-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 LEU A 174
ASN A 181
ARG A 151
 None
 0.84A 2qhfA-5lj6A:
undetectable		 2qhfA-5lj6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 SER A 395
PHE A 422
ILE A 459
SER A 350
PHE A 427
 None
 1.17A 2vdyB-5lj6A:
undetectable		 2vdyB-5lj6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 5 VAL A 285
VAL A 286
GLN A 293
PHE A 526
 None
 1.38A 3bjwB-5lj6A:
1.8		 3bjwB-5lj6A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ILE A  38
ILE A   6
SER A  27
ARG A 211
ILE A 197
 None
 1.12A 3cd2A-5lj6A:
undetectable		 3cd2A-5lj6A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 VAL A 420
LEU A 387
PRO A 415
GLY A 417
LEU A 416
 None
 1.15A 3j6pB-5lj6A:
undetectable		 3j6pB-5lj6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 9 LEU A 448
THR A 362
ALA A 364
LEU A 366
SER A 350
 None
 1.31A 3ozkA-5lj6A:
undetectable		 3ozkA-5lj6A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 368
SER A 349
LEU A 448
ASN A 365
ASN A 347
 None
 1.22A 3q87B-5lj6A:
undetectable		 3q87B-5lj6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 GLN A 394
THR A 454
ASN A 396
 None
 0.63A 3v4tE-5lj6A:
undetectable		 3v4tE-5lj6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 579
ALA A 582
ILE A 575
LEU A 273
ILE A 261
 None
 1.09A 4aztA-5lj6A:
undetectable		 4aztA-5lj6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 8 ARG A 267
GLU A 546
GLU A 550
ARG A 554
 None
 1.24A 4bqfB-5lj6A:
undetectable		 4bqfB-5lj6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 8 GLY A 161
GLY A  88
ILE A 164
LEU A  82
 None
 0.80A 4mwzB-5lj6A:
undetectable		 4mwzB-5lj6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 LEU A 623
GLY A 621
MET A 540
LEU A 541
PHE A 616
 None
 1.34A 4p6xE-5lj6A:
undetectable		 4p6xE-5lj6A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 10 GLY A 132
GLU A 129
LEU A 144
ALA A 102
ALA A 124
 None
 1.24A 4wnuD-5lj6A:
0.0		 4wnuD-5lj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ILE A 215
GLY A  45
ASP A 223
SER A  29
ILE A   6
 None
ATP  A 701 (-3.2A)
None
None
None
 1.19A 5igvA-5lj6A:
undetectable		 5igvA-5lj6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 LYS A  65
ASP A  67
ILE A  52
 None
 0.89A 5kc4E-5lj6A:
3.0		 5kc4E-5lj6A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 5 ASN A 477
VAL A 470
LEU A 335
SER A 484
 None
 1.16A 6a7pA-5lj6A:
3.3		 6a7pA-5lj6A:
21.83