SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.87A 1jnoA-5lj8A:
undetectable		 1jnoA-5lj8A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.87A 1jnoB-5lj8A:
undetectable		 1jnoB-5lj8A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.92A 1jo3A-5lj8A:
undetectable		 1jo3A-5lj8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.92A 1jo3B-5lj8A:
undetectable		 1jo3B-5lj8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.92A 1jo4A-5lj8A:
undetectable		 1jo4A-5lj8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.93A 1jo4B-5lj8A:
undetectable		 1jo4B-5lj8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.87A 1ng8A-5lj8A:
undetectable		 1ng8A-5lj8A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.87A 1ng8B-5lj8A:
undetectable		 1ng8B-5lj8A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.86A 1nruA-5lj8A:
undetectable		 1nruA-5lj8A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.86A 1nruB-5lj8A:
undetectable		 1nruB-5lj8A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A 514
ASP A 322
GLY A 321
PHE A 444
TYR A 327
 None
 1.35A 4fogC-5lj8A:
undetectable		 4fogC-5lj8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A 514
ASP A 322
GLY A 321
PHE A 444
TYR A 327
 None
 1.40A 4foxC-5lj8A:
undetectable		 4foxC-5lj8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 HIS A 514
ASP A 322
GLY A 321
PHE A 444
TYR A 327
 None
 1.40A 4foxE-5lj8A:
undetectable		 4foxE-5lj8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A 514
ASP A 322
GLY A 321
PHE A 444
TYR A 327
 None
 1.42A 4foxF-5lj8A:
undetectable		 4foxF-5lj8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ASP A 501
HIS A 497
LYS A 500
 None
 1.00A 4qzuD-5lj8A:
undetectable		 4qzuD-5lj8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 5 GLY A 321
GLY A 445
GLU A 439
 None
 0.46A 4z2eA-5lj8A:
4.2
4z2eD-5lj8A:
undetectable		 4z2eA-5lj8A:
19.36
4z2eD-5lj8A:
21.66