SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A  87
HIS A 195
THR A 196
ILE A  31
GLY A 163
 None
 1.15A 1gtfQ-5lj9A:
undetectable
1gtfR-5lj9A:
undetectable		 1gtfQ-5lj9A:
14.93
1gtfR-5lj9A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A  87
HIS A 195
THR A 196
ILE A  31
GLY A 163
 None
 1.14A 1gtfS-5lj9A:
undetectable
1gtfT-5lj9A:
undetectable		 1gtfS-5lj9A:
14.93
1gtfT-5lj9A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 HIS A  87
HIS A 195
THR A 196
ILE A  31
GLY A 163
 None
 1.16A 1gtnT-5lj9A:
undetectable
1gtnU-5lj9A:
undetectable		 1gtnT-5lj9A:
14.93
1gtnU-5lj9A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 GLY A 148
LEU A 190
LEU A 132
THR A 172
LEU A 187
 None
 1.39A 1jipA-5lj9A:
undetectable		 1jipA-5lj9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 10 ILE A 221
LEU A   7
ILE A 198
ARG A 212
ILE A 214
 None
 1.23A 1rb3A-5lj9A:
undetectable		 1rb3A-5lj9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 LEU A  29
LEU A  50
SER A  45
ALA A  38
ALA A 210
 None
 1.01A 2br4A-5lj9A:
undetectable		 2br4A-5lj9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 LEU A  29
LEU A  50
SER A  45
ALA A  38
ALA A 210
 None
 1.01A 2br4D-5lj9A:
undetectable		 2br4D-5lj9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 LEU A  29
LEU A  50
SER A  45
ALA A  38
ALA A 210
 None
 1.03A 2br4F-5lj9A:
undetectable		 2br4F-5lj9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 GLU A 108
LEU A 101
MET A 160
ARG A 121
ALA A 111
 None
 1.34A 2jj8B-5lj9A:
undetectable		 2jj8B-5lj9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 11 ILE A 214
LEU A  24
ASN A  52
LEU A  29
ILE A  27
 None
 1.36A 3a50B-5lj9A:
undetectable		 3a50B-5lj9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 6 VAL A 197
MET A  51
ILE A 186
ILE A 166
 None
 0.95A 3gcsA-5lj9A:
undetectable		 3gcsA-5lj9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 ILE A 221
LEU A   7
ILE A 198
ARG A 212
ILE A 214
 None
 1.22A 3ql3A-5lj9A:
undetectable		 3ql3A-5lj9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 ILE A  27
GLY A  41
ALA A  42
SER A  45
GLY A 219
 None
 1.07A 4e1gA-5lj9A:
undetectable		 4e1gA-5lj9A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 ILE A  27
GLY A  41
ALA A  42
SER A  45
GLY A 219
 None
 1.08A 4e1gB-5lj9A:
2.4		 4e1gB-5lj9A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 ILE A 221
LEU A   7
ILE A 198
ARG A 212
ILE A 214
 None
 1.16A 4ptjA-5lj9A:
undetectable		 4ptjA-5lj9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 4 VAL A 183
GLU A 182
GLY A 180
LEU A 175
 None
 1.14A 5g5gC-5lj9A:
undetectable		 5g5gC-5lj9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 THR A  61
SER A  13
ASP A  18
 None
 0.76A 5kvaB-5lj9A:
undetectable		 5kvaB-5lj9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 9 GLY A  44
VAL A 200
ILE A 216
GLY A 219
LEU A  24
 None
 0.86A 5vkqC-5lj9A:
undetectable
5vkqD-5lj9A:
undetectable		 5vkqC-5lj9A:
9.00
5vkqD-5lj9A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 ILE A  10
LEU A  75
LEU A   4
PRO A   3
LEU A   7
 None
 1.27A 5xxiA-5lj9A:
undetectable		 5xxiA-5lj9A:
17.24