SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ljo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 GLU A 138
LYS A 152
VAL A 151
 None
 0.91A 1l2iA-5ljoA:
undetectable		 1l2iA-5ljoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 11 SER A 117
LEU A 165
LEU A 125
LEU A 137
LEU A 167
 None
 1.23A 1mx1B-5ljoA:
undetectable		 1mx1B-5ljoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 VAL A  75
LEU A  66
ARG A  64
PHE A  67
 None
 1.13A 1s8fB-5ljoA:
undetectable		 1s8fB-5ljoA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 HIS A 280
ILE A 284
LEU A 337
GLY A 275
VAL A 322
 None
 1.13A 1tlsB-5ljoA:
undetectable		 1tlsB-5ljoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 8 THR A 571
GLY A 528
THR A 514
VAL A 532
 None
 0.86A 2a1hA-5ljoA:
undetectable
2a1hB-5ljoA:
undetectable		 2a1hA-5ljoA:
18.35
2a1hB-5ljoA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 10 VAL A 532
ARG A 488
THR A 571
GLY A 528
THR A 514
 None
 1.10A 2coiA-5ljoA:
undetectable
2coiB-5ljoA:
undetectable		 2coiA-5ljoA:
19.74
2coiB-5ljoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 379
THR A 402
PHE A 354
 None
 0.75A 2x91A-5ljoA:
undetectable		 2x91A-5ljoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 557
ASP A 562
ASN A 681
 None
 0.97A 3lsfB-5ljoA:
undetectable
3lsfE-5ljoA:
undetectable		 3lsfB-5ljoA:
15.79
3lsfE-5ljoA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 ASP A 562
ASN A 681
SER A 557
 None
 0.98A 3lsfB-5ljoA:
undetectable
3lsfE-5ljoA:
undetectable		 3lsfB-5ljoA:
15.79
3lsfE-5ljoA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 8 ASN A 492
GLN A 495
PHE A 494
ASN A 463
 None
 1.13A 3n66B-5ljoA:
undetectable		 3n66B-5ljoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 TYR A 682
GLU A 689
TYR A 686
 None
 0.89A 3ug8A-5ljoA:
undetectable		 3ug8A-5ljoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 LEU A 641
GLY A 638
GLY A 708
ASP A 639
GLY A 597
 None
 1.02A 4blvA-5ljoA:
undetectable		 4blvA-5ljoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 PHE A 565
TYR A 608
TYR A 548
 None
 1.02A 4ffwA-5ljoA:
undetectable		 4ffwA-5ljoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 11 HIS A 280
ILE A 284
LEU A 337
GLY A 275
VAL A 322
 None
 1.14A 4fogC-5ljoA:
undetectable		 4fogC-5ljoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 TYR A 674
GLN A 540
ASP A 703
ASP A 797
 None
 1.26A 4qtuB-5ljoA:
undetectable		 4qtuB-5ljoA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 9 GLN A 803
PHE A 663
ASP A 740
SER A 769
ALA A 770
 None
 1.23A 4wnuB-5ljoA:
undetectable		 4wnuB-5ljoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 10 GLN A 803
PHE A 663
ASP A 740
SER A 769
ALA A 770
 None
 1.23A 4wnuD-5ljoA:
undetectable		 4wnuD-5ljoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMC
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ASP C  64
ARG A 350
ARG A 353
 None
 0.96A 4x5iA-5ljoC:
undetectable		 4x5iA-5ljoC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 SER A 425
ARG A 583
GLY A 584
THR A 588
 None
 1.05A 5btcA-5ljoA:
undetectable
5btcC-5ljoA:
undetectable
5btcD-5ljoA:
undetectable		 5btcA-5ljoA:
21.06
5btcC-5ljoA:
21.06
5btcD-5ljoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 SER A 425
ARG A 583
GLY A 584
THR A 588
 None
 1.03A 5btcA-5ljoA:
undetectable
5btcB-5ljoA:
undetectable
5btcC-5ljoA:
undetectable		 5btcA-5ljoA:
21.06
5btcB-5ljoA:
18.22
5btcC-5ljoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMC
(Escherichia
coli) 		3 / 3 PRO C  88
LEU C 178
SER C 105
 None
 0.57A 5fsaB-5ljoC:
undetectable		 5fsaB-5ljoC:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ARG A 734
ARG A 583
THR A 588
ILE A 719
 None
 1.21A 5ih0A-5ljoA:
undetectable		 5ih0A-5ljoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 GLY A 407
ASP A 401
ILE A 352
TYR A 319
 None
 0.97A 5iwuA-5ljoA:
undetectable		 5iwuA-5ljoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 11 GLN A 179
VAL A 245
SER A 246
THR A 248
LEU A 219
 None
 1.34A 5jh7B-5ljoA:
undetectable		 5jh7B-5ljoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 11 GLN A 179
VAL A 245
SER A 246
THR A 248
LEU A 219
 None
 1.38A 5jh7D-5ljoA:
undetectable		 5jh7D-5ljoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ARG A  36
ARG A  91
ILE A 130
THR A 128
 None
 1.16A 5vceA-5ljoA:
undetectable		 5vceA-5ljoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 GLY A 221
ILE A 328
GLY A 263
THR A 261
THR A 225
 None
 1.18A 6e8qA-5ljoA:
undetectable		 6e8qA-5ljoA:
8.32