SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 8 ASP A  60
TRP A 144
ARG A 173
THR A 141
 PGE  A 304 (-2.8A)
None
None
None
 1.46A 1ceaA-5lk4A:
undetectable
1ceaB-5lk4A:
undetectable		 1ceaA-5lk4A:
20.37
1ceaB-5lk4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 PRO A 153
LEU A 158
THR A 148
ARG A 221
 None
None
PGE  A 306 (-4.7A)
PO4  A 302 (-3.1A)
 1.07A 1i2wA-5lk4A:
undetectable		 1i2wA-5lk4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 6 ARG A 198
GLY A 160
THR A 180
ARG A  96
 NRQ  A  67 ( 4.3A)
None
None
NRQ  A  67 ( 3.0A)
 1.03A 2f7fA-5lk4A:
undetectable		 2f7fA-5lk4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 ARG A 198
TYR A  84
TYR A 182
LEU A 158
 NRQ  A  67 ( 4.3A)
None
None
None
 1.35A 4f8yA-5lk4A:
undetectable
4f8yB-5lk4A:
undetectable		 4f8yA-5lk4A:
21.28
4f8yB-5lk4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5lk4 MSCARLET
(Discosoma
sp.) 		5 / 9 VAL A 212
VAL A 211
ILE A  30
GLY A  32
ALA A  45
 None
None
None
None
NRQ  A  67 ( 3.3A)
 1.12A 4fwdA-5lk4A:
undetectable		 4fwdA-5lk4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 ASN A  24
MET A  23
HIS A  26
LEU A  55
 None
None
None
PGE  A 304 ( 4.4A)
 1.49A 4g5jA-5lk4A:
undetectable		 4g5jA-5lk4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5lk4 MSCARLET
(Discosoma
sp.) 		5 / 12 PHE A  57
GLN A 214
LEU A  47
VAL A  49
ILE A  30
 None
NRQ  A  67 ( 4.5A)
None
None
None
 1.24A 4k38B-5lk4A:
undetectable		 4k38B-5lk4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.77A 4qa0B-5lk4A:
undetectable		 4qa0B-5lk4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.78A 4qa0A-5lk4A:
undetectable		 4qa0A-5lk4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.83A 4qa2B-5lk4A:
undetectable		 4qa2B-5lk4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 TYR A 121
TYR A  83
SER A  87
 NRQ  A  67 ( 4.5A)
None
None
 0.99A 5iktB-5lk4A:
undetectable		 5iktB-5lk4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 LEU A 151
TYR A 152
LEU A 158
TYR A 182
 None
 1.18A 5ki6A-5lk4A:
undetectable		 5ki6A-5lk4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 6 THR A 148
ARG A 150
ASP A 161
GLY A 160
 PGE  A 306 (-4.7A)
PO4  A 302 (-3.0A)
None
None
 0.95A 5mraA-5lk4A:
undetectable
5mraB-5lk4A:
undetectable		 5mraA-5lk4A:
20.72
5mraB-5lk4A:
20.72