SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 129
ASP A 122
ASP A 340
 None
 0.65A 1eizA-5lkdA:
undetectable		 1eizA-5lkdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 129
ASP A 122
ASP A 340
 None
 0.59A 1ej0A-5lkdA:
undetectable		 1ej0A-5lkdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  60
LEU A  61
THR A  62
ARG A  56
 None
 1.07A 1ekjF-5lkdA:
undetectable
1ekjG-5lkdA:
undetectable		 1ekjF-5lkdA:
19.37
1ekjG-5lkdA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  61
GLY A  60
HIS A 194
PHE A 189
 None
 0.88A 1xf1A-5lkdA:
undetectable		 1xf1A-5lkdA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  61
GLY A  60
HIS A 194
PHE A 189
 None
 0.89A 1xf1B-5lkdA:
undetectable		 1xf1B-5lkdA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 162
GLU A 133
TYR A 138
 None
 1.07A 2a3aA-5lkdA:
undetectable		 2a3aA-5lkdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 108
ASP A 129
ASP A 122
ASP A 340
 None
 1.11A 2nyuB-5lkdA:
undetectable		 2nyuB-5lkdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 108
LEU A  44
ILE A  54
LEU A  53
ALA A 102
 None
 0.95A 2z0yA-5lkdA:
undetectable		 2z0yA-5lkdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 108
LEU A  44
ILE A  54
LEU A  53
ALA A 102
 None
 0.95A 2z0yB-5lkdA:
undetectable		 2z0yB-5lkdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 366
ARG A 313
ILE A 295
ARG A 296
 None
 1.24A 3ckzA-5lkdA:
undetectable		 3ckzA-5lkdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 341
LEU A  44
GLY A 103
GLY A 104
ALA A 130
 None
 1.22A 3i5uA-5lkdA:
undetectable		 3i5uA-5lkdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 341
LEU A  44
GLY A 103
GLY A 104
ALA A 130
 None
 1.18A 3i5uB-5lkdA:
undetectable		 3i5uB-5lkdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 326
PHE A 333
ILE A 288
THR A 278
 None
 0.98A 3mdrA-5lkdA:
undetectable		 3mdrA-5lkdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 216
LEU A 204
LYS A 205
 None
 0.60A 3sueD-5lkdA:
undetectable		 3sueD-5lkdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 247
ASN A 240
THR A 226
ASN A 308
TYR A 316
 None
 1.35A 4dajC-5lkdA:
undetectable		 4dajC-5lkdA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_D_0HKD2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 247
ASN A 240
THR A 226
ASN A 308
TYR A 316
 None
 1.41A 4dajD-5lkdA:
0.0		 4dajD-5lkdA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 287
PHE A 211
VAL A 215
LEU A 253
 None
 0.93A 4f5zA-5lkdA:
undetectable		 4f5zA-5lkdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 PRO A  47
ILE A 295
TYR A 346
TYR A 301
 GSH  A 401 ( 4.6A)
None
None
None
 1.22A 4g10A-5lkdA:
16.2		 4g10A-5lkdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 305
TYR A 224
PHE A  13
ILE A 353
 None
 0.86A 4jx1E-5lkdA:
undetectable		 4jx1E-5lkdA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 106
ASP A 338
ASP A 366
 None
 0.80A 4kicB-5lkdA:
undetectable		 4kicB-5lkdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  65
PHE A 186
LEU A 161
THR A 166
 None
 0.95A 4mmcA-5lkdA:
undetectable		 4mmcA-5lkdA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 245
VAL A 242
GLU A 244
LYS A 248
 None
 1.36A 4p6vB-5lkdA:
undetectable
4p6vE-5lkdA:
undetectable		 4p6vB-5lkdA:
19.38
4p6vE-5lkdA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  15
GLU A 238
TYR A 216
 GSH  A 401 (-4.0A)
None
None
 1.01A 4r29D-5lkdA:
undetectable		 4r29D-5lkdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 215
ALA A 286
ILE A 252
THR A 278
 None
 1.19A 5e4dB-5lkdA:
undetectable		 5e4dB-5lkdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 158
ILE A 177
LEU A 199
LEU A  53
ALA A  57
 GSH  A 401 (-4.0A)
None
None
None
None
 1.33A 5fctB-5lkdA:
undetectable		 5fctB-5lkdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  51
THR A 292
TYR A 301
TYR A 216
 None
 1.10A 5hwaA-5lkdA:
undetectable		 5hwaA-5lkdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 140
HIS A  73
ARG A  80
 None
 1.06A 5iaoC-5lkdA:
undetectable		 5iaoC-5lkdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 140
HIS A  73
ARG A  80
 None
 1.06A 5iaoF-5lkdA:
undetectable		 5iaoF-5lkdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 296
PRO A 299
THR A 337
ILE A 342
 None
 1.22A 5ih0A-5lkdA:
undetectable		 5ih0A-5lkdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A  50
THR A 337
TRP A 322
PHE A 211
 None
 1.41A 5yj1k-5lkdA:
undetectable
5yj1t-5lkdA:
undetectable		 5yj1k-5lkdA:
14.36
5yj1t-5lkdA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 11 THR A 359
PHE A 116
ARG A 125
THR A 107
LEU A  44
 None
 1.37A 6efnA-5lkdA:
undetectable		 6efnA-5lkdA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 11 THR A 359
PHE A 116
THR A 107
LEU A  44
ALA A 130
 None
 1.36A 6efnA-5lkdA:
undetectable		 6efnA-5lkdA:
21.81