SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		3 / 3 ASP A 367
LEU A 395
LEU A 393
 None
 0.75A 1np1B-5lkmA:
undetectable		 1np1B-5lkmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 PHE A 209
LEU A 167
LEU A 197
THR A 232
LEU A  81
 None
 1.15A 1og5A-5lkmA:
undetectable		 1og5A-5lkmA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 6 SER A  89
PHE A 209
ILE A  93
PHE A  77
 None
 1.23A 2qeiA-5lkmA:
undetectable		 2qeiA-5lkmA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 11 VAL A 193
LEU A 197
SER A 171
SER A 122
THR A 150
 None
 1.34A 3bjwE-5lkmA:
undetectable		 3bjwE-5lkmA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 THR A 324
THR A 323
LEU A 361
ILE A 374
MET A 335
 None
 1.34A 3gwxA-5lkmA:
undetectable		 3gwxA-5lkmA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		3 / 3 ILE A 168
SER A 122
SER A 171
 None
 0.47A 3iltH-5lkmA:
undetectable		 3iltH-5lkmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L7K_A_EDTA739_0
(TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 5 LEU A  81
ARG A  69
LYS A  71
ARG A  79
 None
 1.12A 3l7kA-5lkmA:
1.7
3l7kB-5lkmA:
0.7		 3l7kA-5lkmA:
20.64
3l7kB-5lkmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L7M_A_EDTA738_0
(TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 5 LEU A  81
ARG A  69
LYS A  71
ARG A  79
 None
 1.11A 3l7mA-5lkmA:
1.7
3l7mB-5lkmA:
0.7		 3l7mA-5lkmA:
20.93
3l7mB-5lkmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		3 / 3 TYR A 235
GLY A  95
ASP A  96
 None
 0.59A 3ou6C-5lkmA:
3.0		 3ou6C-5lkmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 ALA A 371
GLY A 391
ILE A 444
ILE A 399
VAL A 294
 None
 1.01A 4q5mA-5lkmA:
undetectable		 4q5mA-5lkmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 7 PRO A 433
GLU A 435
GLU A 259
THR A 232
 None
 1.04A 4uacA-5lkmA:
1.7		 4uacA-5lkmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 VAL A 193
LEU A  92
ILE A 210
LEU A 197
ILE A 169
 None
 0.89A 4y0rA-5lkmA:
undetectable		 4y0rA-5lkmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 VAL A 294
VAL A 447
GLY A 391
ALA A 365
LEU A 361
 None
 1.16A 5x23A-5lkmA:
undetectable		 5x23A-5lkmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 9 ALA A 373
SER A 292
GLY A 290
ALA A 356
SER A 355
 None
 1.16A 6bklE-5lkmA:
undetectable
6bklF-5lkmA:
undetectable
6bklG-5lkmA:
undetectable
6bklH-5lkmA:
undetectable		 6bklE-5lkmA:
3.98
6bklF-5lkmA:
3.98
6bklG-5lkmA:
3.98
6bklH-5lkmA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lkm DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 ILE A  93
ILE A 175
VAL A 190
VAL A 193
ILE A 169
 None
 0.90A 6emuC-5lkmA:
undetectable		 6emuC-5lkmA:
17.29