SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	5lkn	NEURAL CELL ADHESION MOLECULE 1 (Homo sapiens)	4 / 7	GLU A 676 MET A 595 ARG A 632 GLY A 680	None	0.88A	2hs1B-5lknA: undetectable	2hs1B-5lknA: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVR_A_URFA2001_1 (URIDINE PHOSPHORYLASE)	5lkn	NEURAL CELL ADHESION MOLECULE 1 (Homo sapiens)	5 / 10	PHE A 687 GLU A 670 LEU A 663 LEU A 660 ILE A 617	None	1.31A	3kvrA-5lknA: undetectable	3kvrA-5lknA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_B_PZIB802_0 (GLUTAMATE RECEPTOR 2)	5lkn	NEURAL CELL ADHESION MOLECULE 1 (Homo sapiens)	3 / 3	SER A 643 ASP A 664 ASN A 666	None	0.97A	3lsfB-5lknA: undetectable 3lsfE-5lknA: undetectable	3lsfB-5lknA: 15.12 3lsfE-5lknA: 15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_E_PZIE802_0 (GLUTAMATE RECEPTOR 2)	5lkn	NEURAL CELL ADHESION MOLECULE 1 (Homo sapiens)	3 / 3	ASP A 664 ASN A 666 SER A 643	None	0.89A	3lsfB-5lknA: undetectable 3lsfE-5lknA: undetectable	3lsfB-5lknA: 15.12 3lsfE-5lknA: 15.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2HS1_B_017B203_1","HIV-1 PROTEASE","5lkn","NEURAL CELL ADHESION MOLECULE 1","Homo sapiens",4,"GLU A 676;MET A 595;ARG A 632;GLY A 680","None","0.88A","2hs1B-5lknA:undetectable","2hs1B-5lknA:20.72"],["3KVR_A_URFA2001_1","URIDINE PHOSPHORYLASE","5lkn","NEURAL CELL ADHESION MOLECULE 1","Homo sapiens",5,"PHE A 687;GLU A 670;LEU A 663;LEU A 660;ILE A 617","None","1.31A","3kvrA-5lknA:undetectable","3kvrA-5lknA:14.47"],["3LSF_B_PZIB802_0","GLUTAMATE RECEPTOR 2","5lkn","NEURAL CELL ADHESION MOLECULE 1","Homo sapiens",3,"SER A 643;ASP A 664;ASN A 666","None","0.97A","3lsfB-5lknA:undetectable;3lsfE-5lknA:undetectable","3lsfB-5lknA:15.12;3lsfE-5lknA:15.12"],["3LSF_E_PZIE802_0","GLUTAMATE RECEPTOR 2","5lkn","NEURAL CELL ADHESION MOLECULE 1","Homo sapiens",3,"ASP A 664;ASN A 666;SER A 643","None","0.89A","3lsfB-5lknA:undetectable;3lsfE-5lknA:undetectable","3lsfB-5lknA:15.12;3lsfE-5lknA:15.12"]]