SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		3 / 3 ASP A 367
LEU A 395
LEU A 393
 None
 0.80A 1np1B-5lkqA:
undetectable		 1np1B-5lkqA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 THR A 324
THR A 323
LEU A 361
ILE A 374
MET A 335
 None
 1.30A 3gwxA-5lkqA:
undetectable		 3gwxA-5lkqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 ARG A 341
ALA A 342
GLN A 445
LEU A 393
ILE A 334
 None
 1.17A 3njzA-5lkqA:
undetectable		 3njzA-5lkqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 5 CYH A 388
PRO A 385
THR A 418
THR A 296
 None
 1.08A 3q07B-5lkqA:
undetectable		 3q07B-5lkqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 6 GLU A 339
GLY A 343
LEU A 346
TYR A 378
 None
 1.15A 3w9tE-5lkqA:
undetectable		 3w9tE-5lkqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		4 / 6 GLU A 339
GLY A 343
LEU A 346
TYR A 378
 None
 1.17A 3w9tF-5lkqA:
undetectable		 3w9tF-5lkqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		3 / 3 SER A 332
MET A 335
ASP A 362
 None
 0.92A 4mm4B-5lkqA:
undetectable		 4mm4B-5lkqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5lkq DNA REPAIR PROTEIN
RADA
(Streptococcus
pneumoniae) 		5 / 12 ALA A 412
ILE A 293
SER A 277
GLY A 391
ILE A 409
 None
 1.01A 5m24A-5lkqA:
undetectable		 5m24A-5lkqA:
24.22