SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.48A 1ceaB-5lkzA:
undetectable		 1ceaB-5lkzA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.46A 1cebB-5lkzA:
undetectable		 1cebB-5lkzA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 CYH A1258
ARG A1645
CYH A1164
 ZN  A1703 (-2.3A)
None
ZN  A1703 (-2.3A)
 1.47A 1p9gA-5lkzA:
undetectable		 1p9gA-5lkzA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 10 LEU A1584
LYS A1583
VAL A1512
LEU A1495
TYR A1585
 None
 1.33A 1sv5A-5lkzA:
1.3		 1sv5A-5lkzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 12 TYR A1585
ILE A1517
SER A1516
SER A1497
PHE A1343
 None
 1.14A 1ve3B-5lkzA:
2.6		 1ve3B-5lkzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 TRP A1649
ARG A1646
PHE A1170
 None
 1.48A 1zeaH-5lkzA:
undetectable
1zeaL-5lkzA:
undetectable		 1zeaH-5lkzA:
16.55
1zeaL-5lkzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 SER A1100
ASP A1098
SER A1072
LEU A1062
 None
 1.05A 2cdqB-5lkzA:
undetectable		 2cdqB-5lkzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 ARG A1281
THR A1248
VAL A1271
 None
 1.00A 2qakA-5lkzA:
undetectable		 2qakA-5lkzA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 6 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.18A 3eteA-5lkzA:
2.8
3eteE-5lkzA:
undetectable		 3eteA-5lkzA:
22.06
3eteE-5lkzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 5 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.17A 3eteB-5lkzA:
2.8
3eteC-5lkzA:
undetectable		 3eteB-5lkzA:
22.06
3eteC-5lkzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 4 VAL A1326
PHE A1361
PHE A1373
VAL A1321
 None
 1.34A 3rv5C-5lkzA:
undetectable
3rv5D-5lkzA:
undetectable		 3rv5C-5lkzA:
9.52
3rv5D-5lkzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 8 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 None
 0.75A 3u5kC-5lkzA:
16.9		 3u5kC-5lkzA:
13.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 6 VAL A1079
LEU A1084
TYR A1131
ASN A1132
VAL A1138
 None
 0.72A 4a9kA-5lkzA:
21.7		 4a9kA-5lkzA:
87.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 12 VAL A1369
LEU A1260
ALA A1647
SER A1643
LEU A1644
 None
 1.04A 4m11B-5lkzA:
1.9		 4m11B-5lkzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 12 VAL A1369
LEU A1260
ALA A1647
SER A1643
LEU A1644
 None
 1.04A 4m11D-5lkzA:
1.9		 4m11D-5lkzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 ASP A1454
HIS A1402
LYS A1456
 None
None
COO  A1705 (-3.7A)
 1.00A 4qzuD-5lkzA:
undetectable		 4qzuD-5lkzA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 6 VAL A1259
CYH A1272
CYH A1247
HIS A1255
 None
ZN  A1702 (-2.3A)
ZN  A1702 (-2.3A)
ZN  A1703 (-3.1A)
 1.43A 5hrqH-5lkzA:
undetectable
5hrqK-5lkzA:
undetectable
5hrqL-5lkzA:
undetectable		 5hrqH-5lkzA:
5.19
5hrqK-5lkzA:
5.82
5hrqL-5lkzA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 GLY A1179
CYH A1177
CYH A1183
 None
ZN  A1701 (-2.3A)
ZN  A1701 (-2.3A)
 0.84A 5inzB-5lkzA:
undetectable		 5inzB-5lkzA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 SER A1289
ALA A1290
THR A1322
 None
 0.70A 5n0xB-5lkzA:
undetectable		 5n0xB-5lkzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 6 PRO A1074
VAL A1079
TYR A1089
ASN A1132
 None
 0.51A 5pbeA-5lkzA:
16.8		 5pbeA-5lkzA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 8 PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
 None
 0.68A 5y1yA-5lkzA:
16.7		 5y1yA-5lkzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 12 ILE A1417
PHE A1374
PHE A1448
ASP A1399
ILE A1395
 None
None
None
COO  A1705 (-4.2A)
None
 1.40A 6dwnB-5lkzA:
undetectable		 6dwnB-5lkzA:
8.33