SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5llt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ALA A  19
HIS A  20
VAL A  23
 DND  A 301 (-3.1A)
DND  A 301 (-4.2A)
None
 0.31A 1lqtB-5lltA:
2.8		 1lqtB-5lltA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ALA A  19
HIS A  20
VAL A  23
 DND  A 301 (-3.1A)
DND  A 301 (-4.2A)
None
 0.32A 1lquB-5lltA:
2.7		 1lquB-5lltA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.27A 2y00A-5lltA:
undetectable		 2y00A-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.30A 2y00B-5lltA:
undetectable		 2y00B-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.31A 2y01B-5lltA:
undetectable		 2y01B-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 HIS A 189
VAL A  23
LEU A  24
PHE A  59
ILE A  16
 None
 1.13A 3kk6B-5lltA:
undetectable		 3kk6B-5lltA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 ILE A 166
ASN A 164
ILE A 134
VAL A  23
 None
None
DND  A 301 ( 4.5A)
None
 0.88A 4uy87-5lltA:
undetectable		 4uy87-5lltA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 GLU A 170
ALA A 171
PHE A 174
 None
 0.67A 4v1fA-5lltA:
undetectable		 4v1fA-5lltA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 PHE A  13
GLY A 107
ASN A 129
ILE A 133
LEU A 108
 DND  A 301 (-4.4A)
None
None
None
DND  A 301 (-4.6A)
 1.17A 6b3bA-5lltA:
2.3		 6b3bA-5lltA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 THR A  17
ALA A 171
LYS A 173
 None
 0.77A 6fgdA-5lltA:
2.5		 6fgdA-5lltA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 LEU A 175
ASP A  14
PRO A  15
ARG A 172
 None
 1.36A 6fgdA-5lltA:
2.5		 6fgdA-5lltA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 5 GLY A  11
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.15A 6jmjA-5lltA:
16.0		 6jmjA-5lltA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 7 GLY A  11
PHE A  13
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.4A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.23A 6jnhA-5lltA:
16.1		 6jnhA-5lltA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 GLY A  11
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.17A 6jogA-5lltA:
16.1		 6jogA-5lltA:
23.04