SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 TRP D 397
VAL D 384
TRP D 386
 None
 1.00A 1c4dA-5llyD:
undetectable
1c4dB-5llyD:
undetectable		 1c4dA-5llyD:
3.95
1c4dB-5llyD:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 ASP D 163
VAL D 165
HIS D 283
GLY D 161
 None
 0.89A 1ekjA-5llyD:
undetectable
1ekjB-5llyD:
undetectable		 1ekjA-5llyD:
18.11
1ekjB-5llyD:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 6 LEU D  35
LEU D 226
LEU D  65
HIS D 230
 None
 0.90A 1errA-5llyD:
undetectable		 1errA-5llyD:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 11 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.38A 1fkjA-5llyD:
undetectable		 1fkjA-5llyD:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ARG D 177
ILE D 179
ILE D 269
TYR D 208
TRP D 174
 None
 1.20A 1ot7A-5llyD:
undetectable		 1ot7A-5llyD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 LYS D 425
ASP D 335
ASP D 504
 None
 0.98A 2br4D-5llyD:
undetectable		 2br4D-5llyD:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 11 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.36A 2fkeA-5llyD:
undetectable		 2fkeA-5llyD:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 6 ARG D 299
ARG D 295
PRO D 217
VAL D 244
 None
CL  D 603 (-3.2A)
None
None
 1.50A 2qd4A-5llyD:
undetectable		 2qd4A-5llyD:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 ASP D 199
TYR D 168
GLY D 176
PRO D 196
 LBV  D 601 (-4.3A)
LBV  D 601 (-3.9A)
None
None
 0.96A 2ys6A-5llyD:
undetectable		 2ys6A-5llyD:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 10 GLY D 361
ALA D 421
PHE D 437
PHE D 416
ARG D 415
 None
 1.41A 3a3yA-5llyD:
undetectable		 3a3yA-5llyD:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 9 ILE D 213
GLY D 268
ILE D 269
VAL D 165
ILE D 156
 None
 1.18A 3ekyB-5llyD:
undetectable		 3ekyB-5llyD:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 10 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.35A 3ihzA-5llyD:
undetectable		 3ihzA-5llyD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 7 ASP D 199
PHE D 195
GLY D 449
PHE D 259
 LBV  D 601 (-4.3A)
LBV  D 601 (-3.6A)
None
None
 1.09A 3vnsA-5llyD:
undetectable		 3vnsA-5llyD:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 ARG D 467
THR D 446
TRP D 447
 None
 1.27A 4d7hA-5llyD:
undetectable		 4d7hA-5llyD:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ILE D 216
ILE D 167
LEU D 152
GLY D 268
ILE D 278
 None
 1.10A 4o1eB-5llyD:
undetectable		 4o1eB-5llyD:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 ARG D 467
THR D 446
TRP D 447
 None
 1.28A 4ug5A-5llyD:
undetectable		 4ug5A-5llyD:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 ARG D 467
THR D 446
TRP D 447
 None
 1.23A 4uglA-5llyD:
undetectable		 4uglA-5llyD:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		3 / 3 ARG D 467
THR D 446
TRP D 447
 None
 1.27A 5g6cA-5llyD:
undetectable		 5g6cA-5llyD:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 TRP D  96
GLY D 106
GLY D 243
VAL D 244
ARG D 294
 None
None
None
None
CL  D 603 (-4.3A)
 1.20A 5o4yD-5llyD:
undetectable
5o4yE-5llyD:
undetectable		 5o4yD-5llyD:
2.76
5o4yE-5llyD:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ILE D 267
GLY D 268
ILE D 215
VAL D 244
ILE D 213
 None
 0.97A 6emuB-5llyD:
undetectable		 6emuB-5llyD:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ILE D 267
GLY D 268
ILE D 215
VAL D 244
ILE D 213
 None
 0.98A 6emuC-5llyD:
undetectable		 6emuC-5llyD:
17.25