SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		4 / 7 VAL A 284
ILE A 285
HIS A 348
LEU A 344
 None
 0.99A 1j96B-5lm7A:
undetectable		 1j96B-5lm7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 10 LEU A 205
GLU A 269
LEU A 266
GLU A 165
LEU A 168
 None
 1.19A 1wopA-5lm7A:
undetectable		 1wopA-5lm7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 ALA A 234
GLY A 268
GLY A 267
LEU A 168
MET A 204
 None
 0.98A 1ya4A-5lm7A:
undetectable		 1ya4A-5lm7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		3 / 3 ARG A 170
GLY A 231
PRO A 230
 None
 0.59A 2hreD-5lm7A:
undetectable		 2hreD-5lm7A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 GLY A 140
GLY A 176
ILE A 138
ASP A 153
LEU A 154
 None
 0.96A 3ihtA-5lm7A:
undetectable		 3ihtA-5lm7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.11A 3ut5D-5lm7A:
undetectable		 3ut5D-5lm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		4 / 6 ILE A 273
SER A 263
PHE A 209
LEU A 205
 A  R  12 ( 4.6A)
None
None
None
 0.97A 4m51A-5lm7A:
undetectable		 4m51A-5lm7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.08A 4x1iD-5lm7A:
undetectable		 4x1iD-5lm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.07A 4x1yD-5lm7A:
undetectable		 4x1yD-5lm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		4 / 6 ALA A 308
SER A 295
GLN A 349
ASP A 342
 None
 1.17A 5c6pA-5lm7A:
undetectable		 5c6pA-5lm7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 1.03A 5eypB-5lm7A:
undetectable		 5eypB-5lm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		3 / 3 ASP A 166
SER A 185
TYR A 184
 None
 0.91A 5glmA-5lm7A:
undetectable		 5glmA-5lm7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 VAL A 186
GLU A 134
GLY A 135
TYR A 184
ILE A 137
 None
 1.49A 5lsaA-5lm7A:
undetectable		 5lsaA-5lm7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 1.05A 5nm5B-5lm7A:
undetectable		 5nm5B-5lm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		5 / 12 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 0.98A 5xiwD-5lm7A:
undetectable		 5xiwD-5lm7A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A 108
ARG A 104
GLU A   4
 None
 0.83A 6c06C-5lm7A:
undetectable		 6c06C-5lm7A:
undetectable