SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 513
LEU A 562
PHE A 523
ILE A 591
ILE A 551
 None
 0.99A 1dyrA-5lmgA:
undetectable		 1dyrA-5lmgA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 556
ILE A 595
ILE A 533
LEU A 527
PHE A 587
 None
 1.05A 1z11B-5lmgA:
undetectable		 1z11B-5lmgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.83A 2eikP-5lmgA:
3.2
2eikW-5lmgA:
undetectable		 2eikP-5lmgA:
18.33
2eikW-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.78A 2eilC-5lmgA:
3.4
2eilJ-5lmgA:
undetectable		 2eilC-5lmgA:
18.33
2eilJ-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.80A 2eimP-5lmgA:
3.4
2eimW-5lmgA:
undetectable		 2eimP-5lmgA:
18.33
2eimW-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 624
LEU A 631
ILE A 634
PHE A 707
LEU A 673
 None
 1.30A 2f7aA-5lmgA:
undetectable		 2f7aA-5lmgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 565
SER A 568
PHE A 587
ILE A 533
 None
 1.12A 2q6hA-5lmgA:
1.0		 2q6hA-5lmgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 565
SER A 568
PHE A 587
ILE A 533
 None
 1.13A 2qb4A-5lmgA:
undetectable		 2qb4A-5lmgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.87A 3abkP-5lmgA:
3.3
3abkW-5lmgA:
undetectable		 3abkP-5lmgA:
18.33
3abkW-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.96A 3ag2P-5lmgA:
1.9
3ag2W-5lmgA:
undetectable		 3ag2P-5lmgA:
18.33
3ag2W-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 610
GLU A 607
LEU A 612
LEU A 613
ILE A 665
 None
 1.03A 3kvrA-5lmgA:
undetectable		 3kvrA-5lmgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 610
GLU A 607
LEU A 612
LEU A 613
ILE A 665
 None
 1.01A 3kvrB-5lmgA:
undetectable		 3kvrB-5lmgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 610
GLU A 607
LEU A 612
LEU A 613
ILE A 665
 None
 1.05A 3nbqA-5lmgA:
undetectable		 3nbqA-5lmgA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 634
ILE A 638
TYR A 666
ALA A 709
LEU A 673
 None
None
EDO  A 808 (-4.2A)
None
None
 1.09A 3ozvB-5lmgA:
undetectable		 3ozvB-5lmgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 513
LEU A 562
PHE A 523
ILE A 591
ILE A 551
 None
 0.90A 3tq8A-5lmgA:
undetectable		 3tq8A-5lmgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.11A 4a97E-5lmgA:
3.1		 4a97E-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.10A 4a97C-5lmgA:
undetectable		 4a97C-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.07A 4a97H-5lmgA:
0.8		 4a97H-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 681
VAL A 727
ILE A 724
GLU A 701
 None
None
None
EDO  A 804 (-2.9A)
 1.08A 4a97I-5lmgA:
2.9		 4a97I-5lmgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 673
ILE A 634
LEU A 631
SER A 710
LEU A 711
 None
 0.97A 4m11A-5lmgA:
undetectable		 4m11A-5lmgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 673
ILE A 634
LEU A 631
SER A 710
LEU A 711
 None
 1.03A 4o1zB-5lmgA:
1.7		 4o1zB-5lmgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 552
LEU A 559
ILE A 636
LEU A 637
ILE A 594
 None
None
EDO  A 806 (-4.3A)
None
None
 0.93A 4odrA-5lmgA:
undetectable
4odrB-5lmgA:
undetectable		 4odrA-5lmgA:
13.28
4odrB-5lmgA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 535
ILE A 539
ILE A 594
ILE A 590
ILE A 591
 None
 0.94A 5murE-5lmgA:
2.7		 5murE-5lmgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.80A 5x19C-5lmgA:
3.5
5x19J-5lmgA:
undetectable		 5x19C-5lmgA:
18.33
5x19J-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 533
GLY A 532
ILE A 535
ILE A 555
ILE A 591
 None
 1.07A 6emuB-5lmgA:
undetectable		 6emuB-5lmgA:
18.37