SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 5 GLU A 160
ALA A 163
SER A 166
HIS A 168
 None
 1.27A 1errA-5lmzA:
undetectable
1errB-5lmzA:
undetectable		 1errA-5lmzA:
21.61
1errB-5lmzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.21A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 LEU A 273
ASN A 219
VAL A 195
GLY A 204
LEU A 225
 None
 1.18A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 0.96A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 11 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.19A 1fkpA-5lmzA:
undetectable		 1fkpA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 11 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 1.17A 1fkpA-5lmzA:
undetectable		 1fkpA-5lmzA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
None
 0.28A 1rqpA-5lmzA:
43.0		 1rqpA-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		7 / 7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
 0.72A 1rqpB-5lmzA:
43.1		 1rqpB-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
None
 0.22A 1rqpB-5lmzA:
43.1		 1rqpB-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		8 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
 0.68A 1rqpC-5lmzA:
42.8		 1rqpC-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		8 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
 0.64A 1rqpA-5lmzA:
43.0		 1rqpA-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
None
 0.25A 1rqpC-5lmzA:
42.8		 1rqpC-5lmzA:
87.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 7 ASP A  16
TYR A  77
PRO A  78
THR A  80
 None
CL  A 302 ( 4.6A)
CL  A 302 ( 3.7A)
None
 0.32A 2q6kA-5lmzA:
32.1		 2q6kA-5lmzA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		7 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
1DA  A 301 (-3.0A)
 0.35A 2v7uA-5lmzA:
42.9		 2v7uA-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		7 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
None
None
1DA  A 301 (-3.0A)
 0.73A 2v7uA-5lmzA:
42.9		 2v7uA-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_A_SAMA1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
 0.30A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
 0.33A 2v7uA-5lmzA:
42.9		 2v7uA-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		6 / 7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
 0.38A 2v7uB-5lmzA:
42.9		 2v7uB-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		6 / 7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
SER A 269
ARG A 270
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
None
None
 0.81A 2v7uB-5lmzA:
42.9		 2v7uB-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1300_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
 0.32A 2v7uB-5lmzA:
42.9		 2v7uB-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		8 / 9 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ALA A 276
ASN A 278
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
1DA  A 301 (-3.0A)
1DA  A 301 ( 4.4A)
 0.35A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		8 / 9 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
 0.69A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 12 ALA A 121
PRO A 122
VAL A 162
ASP A  16
PHE A  13
 None
 1.25A 2v95A-5lmzA:
undetectable		 2v95A-5lmzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_A_ADNA501_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
1DA  A 301 (-3.3A)
1DA  A 301 ( 4.4A)
 0.27A 2zbuA-5lmzA:
30.3		 2zbuA-5lmzA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_C_ADNC503_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
1DA  A 301 (-3.3A)
1DA  A 301 ( 4.4A)
 0.28A 2zbuC-5lmzA:
30.4		 2zbuC-5lmzA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		3 / 3 PHE A 213
ASN A 215
PHE A 254
 1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
1DA  A 301 (-3.3A)
 0.25A 2zbuD-5lmzA:
30.3		 2zbuD-5lmzA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.22A 3lp1A-5lmzA:
undetectable		 3lp1A-5lmzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 1.02A 3lp1A-5lmzA:
undetectable		 3lp1A-5lmzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 12 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.10A 3medA-5lmzA:
undetectable
3medB-5lmzA:
undetectable		 3medA-5lmzA:
18.65
3medB-5lmzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 12 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 0.96A 3medA-5lmzA:
undetectable
3medB-5lmzA:
undetectable		 3medA-5lmzA:
18.65
3medB-5lmzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 7 ASN A 123
ALA A 121
THR A  74
LEU A 131
 None
 1.00A 4ejgA-5lmzA:
undetectable		 4ejgA-5lmzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 11 ILE A  91
LEU A 175
ALA A 121
ILE A  59
VAL A 130
 None
 1.01A 4h1nA-5lmzA:
undetectable		 4h1nA-5lmzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 10 LEU A 244
LEU A 288
ILE A 216
LEU A 282
LEU A 273
 None
 1.10A 4odoB-5lmzA:
undetectable		 4odoB-5lmzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		4 / 8 LEU A 126
VAL A 162
VAL A  87
TYR A 119
 None
 0.80A 4pwdC-5lmzA:
undetectable		 4pwdC-5lmzA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B6I_A_ADNA302_1
(FLUORINASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		7 / 7 ASP A  16
TRP A  50
THR A  76
TYR A  77
PRO A  78
THR A  80
SER A 158
 None
None
None
CL  A 302 ( 4.6A)
CL  A 302 ( 3.7A)
None
None
 0.16A 5b6iA-5lmzA:
43.8		 5b6iA-5lmzA:
99.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B6I_B_ADNB302_1
(FLUORINASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		6 / 6 ASP A  16
TRP A  50
THR A  76
TYR A  77
THR A  80
SER A 158
 None
None
None
CL  A 302 ( 4.6A)
None
None
 0.15A 5b6iB-5lmzA:
43.3		 5b6iB-5lmzA:
99.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 12 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 1.03A 6emuB-5lmzA:
undetectable		 6emuB-5lmzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5lmz FLUORINASE
(Streptomyces
sp.
MA37) 		5 / 12 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 1.04A 6emuC-5lmzA:
undetectable		 6emuC-5lmzA:
21.43