SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lnk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 11 LEU d  94
VAL d  95
ILE d 117
VAL d  91
PHE d 129
 NDP  d 401 ( 4.7A)
NDP  d 401 (-4.4A)
None
None
None
 1.35A 1gx9A-5lnkd:
undetectable		 1gx9A-5lnkd:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		4 / 7 VAL k 155
SER k 103
LEU k 106
ALA k  59
 None
 0.80A 1j8uA-5lnkk:
undetectable		 1j8uA-5lnkk:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
MITOCHONDRIAL
COMPLEX I, AGGG
SUBUNIT
(Ovis
aries;
Ovis
aries) 		5 / 12 TRP u  33
ILE L 374
ILE L 375
MET u  32
ALA u  30
 None
 1.41A 1ki7A-5lnku:
undetectable		 1ki7A-5lnku:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
MITOCHONDRIAL
COMPLEX I, AGGG
SUBUNIT
(Ovis
aries;
Ovis
aries) 		5 / 12 TRP u  33
ILE L 374
ILE L 375
MET u  32
ALA u  30
 None
 1.35A 1ki7B-5lnku:
undetectable		 1ki7B-5lnku:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 GLY L 148
GLU L 145
GLY L 146
GLY L 143
GLY L 222
 None
None
CDL  L 601 ( 4.6A)
None
None
 0.94A 1n2xB-5lnkL:
undetectable		 1n2xB-5lnkL:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 PHE L 189
LEU L 190
LEU L 211
PRO L 212
LEU L 216
 None
 1.23A 1og5A-5lnkL:
undetectable		 1og5A-5lnkL:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5lnk MITOCHONDRIAL
COMPLEX I, PDSW
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B17
SUBUNIT
(Ovis
aries;
Ovis
aries) 		3 / 3 ALA Z  35
VAL Z  40
TRP r  79
 None
 0.71A 1tkqB-5lnkZ:
undetectable		 1tkqB-5lnkZ:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L 247
THR L  97
ILE L 100
MET L 101
PHE L 124
 None
 1.41A 1xlxA-5lnkL:
undetectable		 1xlxA-5lnkL:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 TYR k 171
ARG k 126
GLY k  34
LYS k  35
 None
 1.49A 2i30A-5lnkk:
undetectable		 2i30A-5lnkk:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 ILE d 214
ILE d  92
LEU d  34
ASN d  36
VAL d  45
 None
 0.99A 2nnhA-5lnkd:
undetectable		 2nnhA-5lnkd:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 10 ILE d 214
ILE d  92
LEU d  34
ASN d  36
VAL d  45
 None
 0.99A 2nnhB-5lnkd:
undetectable		 2nnhB-5lnkd:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 ILE k  31
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.17A 2no6A-5lnkk:
16.0		 2no6A-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		6 / 12 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.40A 2no6A-5lnkk:
16.0		 2no6A-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 11 ILE k  31
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.18A 2no6B-5lnkk:
16.1		 2no6B-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		6 / 11 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.38A 2no6B-5lnkk:
16.1		 2no6B-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
 None
 1.35A 2noaA-5lnkk:
16.0		 2noaA-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 11 ILE k  31
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.18A 2noaB-5lnkk:
15.9		 2noaB-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		6 / 11 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.43A 2noaB-5lnkk:
15.9		 2noaB-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 0.99A 2v2gA-5lnkL:
undetectable
2v2gB-5lnkL:
undetectable		 2v2gA-5lnkL:
16.67
2v2gB-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.01A 2v2gA-5lnkL:
undetectable
2v2gB-5lnkL:
undetectable		 2v2gA-5lnkL:
16.67
2v2gB-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.00A 2v2gC-5lnkL:
undetectable
2v2gD-5lnkL:
undetectable		 2v2gC-5lnkL:
16.67
2v2gD-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.01A 2v2gC-5lnkL:
undetectable
2v2gD-5lnkL:
undetectable		 2v2gC-5lnkL:
16.67
2v2gD-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.00A 2v32C-5lnkL:
undetectable
2v32D-5lnkL:
undetectable		 2v32C-5lnkL:
16.67
2v32D-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 0.97A 2v41C-5lnkL:
undetectable
2v41D-5lnkL:
undetectable		 2v41C-5lnkL:
16.67
2v41D-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 0.99A 2v41C-5lnkL:
undetectable
2v41D-5lnkL:
undetectable		 2v41C-5lnkL:
16.67
2v41D-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.02A 2v41E-5lnkL:
undetectable
2v41F-5lnkL:
undetectable		 2v41E-5lnkL:
16.67
2v41F-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.02A 2v41E-5lnkL:
undetectable
2v41F-5lnkL:
undetectable		 2v41E-5lnkL:
16.67
2v41F-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.00A 2v41G-5lnkL:
undetectable
2v41H-5lnkL:
undetectable		 2v41G-5lnkL:
16.67
2v41H-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 241
PRO L 242
VAL L 243
SER L 244
 None
 1.01A 2v41G-5lnkL:
undetectable
2v41H-5lnkL:
undetectable		 2v41G-5lnkL:
16.67
2v41H-5lnkL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
8, MITOCHONDRIAL
(Ovis
aries;
Ovis
aries) 		3 / 3 HIS v 104
MET L 283
MET L 290
 None
 0.99A 2vj1A-5lnkv:
undetectable		 2vj1A-5lnkv:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT
MITOCHONDRIAL
COMPLEX I, KFYI
SUBUNIT
(Ovis
aries) 		4 / 4 TYR o  73
LEU o  76
LEU o  31
HIS x  35
 None
 1.14A 2x7hB-5lnko:
undetectable		 2x7hB-5lnko:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
 None
 1.44A 2ziaA-5lnkk:
16.3		 2ziaA-5lnkk:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		3 / 3 GLY d  12
GLY d  39
GLY d  42
 None
 0.26A 3bogC-5lnkd:
undetectable		 3bogC-5lnkd:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		3 / 3 GLY d  12
GLY d  39
GLY d  42
 None
 0.24A 3bogD-5lnkd:
undetectable		 3bogD-5lnkd:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 10 ILE L 472
ILE L 468
GLY L 388
PHE L 389
LEU L 324
 None
 1.36A 3elzB-5lnkL:
undetectable		 3elzB-5lnkL:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT
(Ovis
aries;
Ovis
aries) 		4 / 4 ARG g  76
ASP c  18
ASP g  74
PRO g  75
 None
 1.28A 3fgrB-5lnkg:
undetectable		 3fgrB-5lnkg:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L   7
THR L 133
THR L  46
LEU L  14
LEU L 129
 None
 1.30A 3g1uB-5lnkL:
undetectable		 3g1uB-5lnkL:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L   7
THR L 133
THR L  46
LEU L  14
LEU L 129
 None
 1.27A 3g1uD-5lnkL:
undetectable		 3g1uD-5lnkL:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		4 / 4 GLN d 115
PRO d 114
VAL d 156
GLU d 153
 None
 1.45A 3huoA-5lnkd:
undetectable		 3huoA-5lnkd:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 9 ILE L  62
MET L  82
PHE L  85
GLY L  58
PHE L  54
 None
 1.01A 3ko0A-5lnkL:
undetectable
3ko0C-5lnkL:
undetectable		 3ko0A-5lnkL:
11.50
3ko0C-5lnkL:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH201_1
(PROTEIN S100-A4)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 9 ILE L  62
MET L  82
PHE L  85
GLY L  58
PHE L  54
 None
 1.02A 3ko0H-5lnkL:
undetectable
3ko0I-5lnkL:
undetectable		 3ko0H-5lnkL:
11.50
3ko0I-5lnkL:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 10 GLY L  58
PHE L  54
ILE L  62
MET L  82
PHE L  85
 None
 1.10A 3ko0L-5lnkL:
undetectable
3ko0N-5lnkL:
undetectable		 3ko0L-5lnkL:
11.50
3ko0N-5lnkL:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L   7
THR L 133
THR L  46
LEU L  14
LEU L 129
 None
 1.29A 3n58D-5lnkL:
undetectable		 3n58D-5lnkL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 ASN d  36
TYR d  33
TYR d 206
GLU d 316
 None
 0.95A 3q5sA-5lnkd:
undetectable		 3q5sA-5lnkd:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 VAL d 208
ASN d  36
TYR d 206
GLU d 316
 None
 1.12A 3q5sA-5lnkd:
undetectable		 3q5sA-5lnkd:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT
(Ovis
aries) 		3 / 3 ASN o  46
ALA o  56
ARG o  51
 None
 0.60A 3tj7C-5lnko:
undetectable
3tj7D-5lnko:
undetectable		 3tj7C-5lnko:
18.78
3tj7D-5lnko:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L 431
LEU L 373
ILE L 356
ILE L 346
PHE L 340
 None
 1.14A 4a7aB-5lnkL:
undetectable		 4a7aB-5lnkL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 ASP k  28
ASP k 131
ARG k 104
GLU k 125
 None
 1.23A 4eysA-5lnkk:
undetectable		 4eysA-5lnkk:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 SER k 130
ASP k 131
ARG k 104
GLU k 125
 None
 1.15A 4eysA-5lnkk:
undetectable		 4eysA-5lnkk:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L  94
VAL L  90
ALA L  43
PHE L  44
LEU L   7
 None
 1.17A 4i1rA-5lnkL:
undetectable		 4i1rA-5lnkL:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		3 / 3 SER k  93
TYR k  94
PRO k  86
 None
 0.91A 4kbeB-5lnkk:
undetectable		 4kbeB-5lnkk:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 11 GLY k  47
GLY k 121
ALA k  43
LEU k  48
HIS k  50
 None
 1.04A 4l8fB-5lnkk:
undetectable		 4l8fB-5lnkk:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT
(Ovis
aries) 		5 / 11 GLY k  47
GLY k 121
ALA k  43
LEU k  48
HIS k  50
 None
 1.02A 4l8fD-5lnkk:
undetectable		 4l8fD-5lnkk:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 ILE d 132
ILE d 218
LEU d 303
VAL d 305
ILE d 166
 None
 0.96A 4m2xG-5lnkd:
undetectable		 4m2xG-5lnkd:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 ALA L 415
GLY L 311
THR L 316
LEU L 324
ILE L 319
 None
 1.06A 4n48B-5lnkL:
undetectable		 4n48B-5lnkL:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT
(Ovis
aries) 		4 / 6 VAL g  77
LEU g  80
ARG g  76
LEU c  22
 None
 1.11A 4o1zA-5lnkg:
undetectable		 4o1zA-5lnkg:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 LEU L 247
LEU L 310
GLY L 256
MET L 128
PHE L 124
 None
 1.35A 4pgfA-5lnkL:
undetectable		 4pgfA-5lnkL:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 ALA L 236
ILE L 149
THR L 251
VAL L 254
 None
 0.79A 4r20A-5lnkL:
undetectable		 4r20A-5lnkL:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 12 GLY d 125
ALA d 124
PHE d 129
ALA d 118
VAL d 156
 None
 1.32A 4ryaA-5lnkd:
undetectable		 4ryaA-5lnkd:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B17
SUBUNIT
(Ovis
aries;
Ovis
aries) 		4 / 7 SER L  79
ILE L  62
LYS L  81
VAL r  97
 None
 1.22A 4tvtA-5lnkL:
undetectable		 4tvtA-5lnkL:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		5 / 10 GLY d  31
ALA d 217
ILE d  92
LEU d  34
LEU d  94
 None
None
None
None
NDP  d 401 ( 4.7A)
 1.17A 4xj7A-5lnkd:
4.4
4xj7B-5lnkd:
4.2		 4xj7A-5lnkd:
21.45
4xj7B-5lnkd:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5lnk MITOCHONDRIAL
COMPLEX I, B16.6
SUBUNIT
(Ovis
aries) 		4 / 5 GLY q 125
ARG q 127
GLY q 129
GLU q 131
 None
 0.91A 4z2eB-5lnkq:
undetectable
4z2eC-5lnkq:
undetectable		 4z2eB-5lnkq:
14.84
4z2eC-5lnkq:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 412
LEU L 413
THR L 401
LEU L 486
 None
 0.78A 4z90F-5lnkL:
undetectable
4z90G-5lnkL:
undetectable
4z90H-5lnkL:
undetectable
4z90I-5lnkL:
undetectable
4z90J-5lnkL:
undetectable		 4z90F-5lnkL:
19.24
4z90G-5lnkL:
19.24
4z90H-5lnkL:
19.24
4z90I-5lnkL:
19.24
4z90J-5lnkL:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 7 THR L 412
LEU L 413
THR L 401
LEU L 486
 None
 0.78A 4z91F-5lnkL:
undetectable
4z91G-5lnkL:
undetectable
4z91H-5lnkL:
undetectable
4z91I-5lnkL:
undetectable
4z91J-5lnkL:
undetectable		 4z91F-5lnkL:
19.24
4z91G-5lnkL:
19.24
4z91H-5lnkL:
19.24
4z91I-5lnkL:
19.24
4z91J-5lnkL:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 4 THR L 316
LEU L 312
HIS L 328
GLY L 311
 None
 0.82A 5gwyA-5lnkL:
undetectable		 5gwyA-5lnkL:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		4 / 8 THR L 370
SER L 345
SER L 349
ALA L 365
 None
 1.03A 5l5fY-5lnkL:
undetectable
5l5fZ-5lnkL:
undetectable		 5l5fY-5lnkL:
15.27
5l5fZ-5lnkL:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		3 / 3 HIS d 134
SER d 133
LYS d 149
 NDP  d 401 (-4.2A)
None
None
 0.73A 5os7A-5lnkd:
undetectable		 5os7A-5lnkd:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT
(Ovis
aries;
Ovis
aries) 		4 / 7 ARG g 113
GLU c  27
PRO c  78
PRO c  26
 None
 1.29A 6a4iB-5lnkg:
undetectable		 6a4iB-5lnkg:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT
(Ovis
aries) 		4 / 5 GLY o  42
ASN o  46
ASP o  45
ARG o  60
 None
None
None
3PE  o 203 (-3.3A)
 1.40A 6dwdB-5lnko:
undetectable
6dwdD-5lnko:
undetectable		 6dwdB-5lnko:
13.13
6dwdD-5lnko:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT
(Ovis
aries) 		4 / 5 ARG o  60
GLY o  42
ASN o  46
ASP o  45
 3PE  o 203 (-3.3A)
None
None
None
 1.26A 6dwjB-5lnko:
undetectable
6dwjD-5lnko:
undetectable		 6dwjB-5lnko:
13.13
6dwjD-5lnko:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		4 / 6 PHE d 172
VAL d 245
LEU d 237
ARG d 235
 None
 0.97A 6e43D-5lnkd:
undetectable		 6e43D-5lnkd:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		4 / 4 GLN d 306
THR d 308
THR d 211
LEU d 300
 None
 1.50A 6f3mA-5lnkd:
3.9		 6f3mA-5lnkd:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT
(Ovis
aries) 		3 / 3 HIS d 134
SER d 133
LYS d 149
 NDP  d 401 (-4.2A)
None
None
 0.73A 6gmdB-5lnkd:
undetectable		 6gmdB-5lnkd:
22.92