SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lnq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
3 / 3 MET A  61
LEU A  66
SER A  67
None
0.63A 1ee2A-5lnqA:
undetectable
1ee2A-5lnqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 LEU A 288
LEU A 438
ALA A 295
ALA A 436
LEU A 270
None
1.29A 1kt5A-5lnqA:
undetectable
1kt5A-5lnqA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 GLY A  79
THR A  60
VAL A  57
LEU A  92
LEU A  53
None
1.09A 1mx1C-5lnqA:
undetectable
1mx1C-5lnqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 10 ALA A 147
ILE A  17
GLY A  19
GLY A  20
ILE A 395
None
0.94A 1sdvA-5lnqA:
undetectable
1sdvA-5lnqA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ALA A 142
GLN A  75
LEU A 137
ALA A 136
LEU A  66
None
1.06A 1xdkA-5lnqA:
undetectable
1xdkA-5lnqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ALA A 142
GLN A  75
LEU A 137
ALA A 136
LEU A  66
None
1.06A 1xdkE-5lnqA:
undetectable
1xdkE-5lnqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 LEU A 371
GLY A 381
ASN A 378
ALA A 211
ALA A 208
None
1.17A 2bm9C-5lnqA:
undetectable
2bm9C-5lnqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 11 GLY A 394
SER A 125
THR A 393
HIS A 388
PHE A 341
None
None
None
CAA  A 501 (-4.1A)
CAA  A 501 ( 4.6A)
1.44A 2hmaA-5lnqA:
undetectable
2hmaA-5lnqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
4 / 5 ALA A 124
ALA A 317
ALA A 321
GLN A 397
None
0.92A 2nyrB-5lnqA:
undetectable
2nyrB-5lnqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
4 / 5 LEU A 165
LEU A 185
MET A 426
CYH A 258
CAA  A 501 (-3.4A)
None
CAA  A 501 (-4.8A)
CAA  A 501 (-3.8A)
1.10A 2oaxD-5lnqA:
undetectable
2oaxD-5lnqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
4 / 4 VAL A  57
THR A  56
VAL A 150
GLY A 149
None
1.16A 2p2fB-5lnqA:
undetectable
2p2fB-5lnqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 MET A 134
ALA A  12
ALA A 129
THR A 423
LEU A 438
None
1.04A 2x2nB-5lnqA:
undetectable
2x2nB-5lnqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ALA A  96
LEU A  53
ILE A 395
GLY A 267
LEU A 146
None
1.07A 2yjaB-5lnqA:
undetectable
2yjaB-5lnqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 GLN A 404
ALA A 411
ASN A 218
GLY A 380
LEU A 220
None
1.20A 3aodC-5lnqA:
undetectable
3aodC-5lnqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ILE A 354
ALA A 355
LEU A 363
ALA A 360
LEU A 322
None
1.09A 3dzyA-5lnqA:
undetectable
3dzyA-5lnqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 9 ARG A  14
ALA A 436
GLY A 421
LEU A 420
ILE A 291
None
1.17A 3em4B-5lnqA:
undetectable
3em4B-5lnqA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 HIS A 388
LEU A 383
GLY A 394
SER A 132
ALA A 123
CAA  A 501 (-4.1A)
None
None
None
CAA  A 501 (-3.1A)
1.16A 3i5uB-5lnqA:
undetectable
3i5uB-5lnqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 11 ALA A 122
SER A 125
ASN A  80
GLN A 153
ARG A 118
CAA  A 501 (-3.2A)
None
None
None
None
1.45A 3kp5A-5lnqA:
undetectable
3kp5A-5lnqA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
3 / 3 VAL A  73
VAL A  18
SER A  64
None
0.65A 3n8xB-5lnqA:
undetectable
3n8xB-5lnqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.41A 4ctkC-5lnqA:
undetectable
4ctkC-5lnqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 10 THR A 155
GLY A  83
ASP A 263
ILE A  52
VAL A 150
None
1.06A 4jx1B-5lnqA:
undetectable
4jx1B-5lnqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
3 / 3 LYS A 328
PRO A 329
SER A 330
None
0.49A 4k50I-5lnqA:
undetectable
4k50I-5lnqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ALA A 122
GLU A 151
HIS A 338
HIS A 388
GLY A 427
CAA  A 501 (-3.2A)
None
CAA  A 501 (-4.1A)
CAA  A 501 (-4.1A)
CAA  A 501 (-3.1A)
0.59A 4ls7A-5lnqA:
27.0
4ls7A-5lnqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ASN A 440
ILE A 417
LEU A 276
GLY A  19
ILE A  17
None
1.15A 4o1eA-5lnqA:
undetectable
4o1eA-5lnqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ASN A 440
ILE A 417
LEU A 276
GLY A  19
ILE A  17
None
1.15A 4o1eB-5lnqA:
undetectable
4o1eB-5lnqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
4 / 6 MET A 279
ILE A 395
ILE A 398
VAL A 130
None
0.86A 4olmA-5lnqA:
undetectable
4olmA-5lnqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 11 ALA A  96
LEU A  53
ILE A 395
GLY A 267
LEU A 146
None
1.11A 4pxmB-5lnqA:
undetectable
4pxmB-5lnqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 11 ALA A  96
LEU A  53
ILE A 395
GLY A 267
LEU A 146
None
1.12A 5dxbB-5lnqA:
undetectable
5dxbB-5lnqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.37A 5e9qC-5lnqA:
undetectable
5e9qC-5lnqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.45A 5eiwC-5lnqA:
undetectable
5eiwC-5lnqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
5 / 12 ALA A  96
LEU A  53
ILE A 395
GLY A 267
LEU A 146
None
1.11A 5gtrA-5lnqA:
undetectable
5gtrA-5lnqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
3 / 3 GLY A 126
THR A 393
ASN A 425
None
0.63A 5odiG-5lnqA:
undetectable
5odiG-5lnqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.43A 5wz1B-5lnqA:
undetectable
5wz1B-5lnqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.45A 5wz2A-5lnqA:
undetectable
5wz2A-5lnqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
6 / 12 GLY A 391
GLY A 427
GLY A 121
GLY A 126
THR A 432
LYS A 431
None
CAA  A 501 (-3.1A)
None
None
None
None
1.44A 5wz2B-5lnqA:
undetectable
5wz2B-5lnqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana)
4 / 6 LEU A 270
ALA A 147
LEU A 438
THR A 423
None
0.82A 6f88B-5lnqA:
undetectable
6f88B-5lnqA:
11.21