SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 ILE A 244
ASN A 157
GLY A 240
LEU A 237
 None
None
None
GOL  A 401 ( 4.5A)
 0.94A 1dzmA-5lnxA:
undetectable		 1dzmA-5lnxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 VAL A 332
LEU A 349
LEU A 350
TYR A 203
GLU A  30
 None
 1.36A 1kw0A-5lnxA:
undetectable		 1kw0A-5lnxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 4 GLY A  44
LYS A  45
GLY A  47
HIS A  46
 None
GOL  A 402 ( 3.7A)
None
GOL  A 402 (-4.4A)
 1.27A 1mf1A-5lnxA:
undetectable		 1mf1A-5lnxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 LEU A 135
HIS A 231
ALA A 233
LEU A 237
LEU A 223
 None
GOL  A 403 (-4.1A)
None
GOL  A 401 ( 4.5A)
None
 1.32A 2azqA-5lnxA:
undetectable		 2azqA-5lnxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 LEU A  69
ALA A 246
ILE A  71
SER A  75
 None
 1.12A 2othA-5lnxA:
undetectable		 2othA-5lnxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 ILE A  22
ALA A  25
ALA A  26
LEU A  39
ILE A  71
 None
 0.88A 3fc6A-5lnxA:
undetectable		 3fc6A-5lnxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 LEU A  39
ILE A  84
GLY A  82
ALA A  80
SER A  78
 None
 1.06A 3n8zB-5lnxA:
undetectable		 3n8zB-5lnxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lnx ACYL-COA
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 ILE A  22
ALA A  25
ALA A  26
LEU A  39
ILE A  71
 None
 1.13A 4nqaH-5lnxA:
undetectable		 4nqaH-5lnxA:
21.19